DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and FZD8

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_114072.1	Gene:	FZD8 / 8325	HGNCID:	4046	Length:	694	Species:	Homo sapiens

Alignment Length:	704	Identity:	172/704 - (24%)
Similarity:	276/704 - (39%)	Gaps:	198/704 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGN 70
            :..||..:.|..|          |:.::::|..|:    .|:.|.:.:|:.||||.|.|||...:
Human     9 VTSLLAALALLQR----------SSGAAAASAKEL----ACQEITVPLCKGIGYNYTYMPNQFNH 59

  Fly    71 EMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTP--KAPVHAIGPCRSLCESVRIRCHPV 133
            :.|.:....:..|.||:|..||..||.|||:.|.|:|..  |.|   :.||||:||..:..|.|:
Human    60 DTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKP---LPPCRSVCERAKAGCAPL 121

  Fly   134 LQGFGFPWPPALDCDKFPRENNHETMCME--------------------GPGELHQPQQEQ---- 174
            ::.:||.||..:.||:.|.:.|.:|:||:                    .|||  ||....
Human   122 MRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGE--QPPSGSGHGR 184

  Fly   175 ------------------DLYGLPGQGIPGGLGGK------------------LPMDCSGLAKSH 203
                              |....|.:|  ||.|||                  .||......:..
Human   185 PPGARPPHRGGGRGGGGGDAAAPPARG--GGGGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHP 247

  Fly   204 LYVRLPRSGR---CAPLCEADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASA 265
            ||.|: ::|:   ||..|. :..|:..|:.....|:..|:.... ::..|||.....|..|....
Human   248 LYNRV-KTGQIANCALPCH-NPFFSQDERAFTVFWIGLWSVLCF-VSTFATVSTFLIDMERFKYP 309

  Fly   266 KWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTAC-----------------------GTDPQA 304
            :     .|:|:   |:..|::|:.||.:.|....||                       |.....
Human   310 E-----RPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGG 369

  Fly   305 PN-----------ESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKG 358
            |.           |..:..:....|.|..|||:.|:||||:..||.:|.|.|
Human   370 PGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTW------------- 421

  Fly   359 HVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGN 423
                   |..:..|..:...|    ..:.:....||.:|:.::.||:....||.|.:.|.|:|||
Human   422 -------FLAAGMKWGNEAIA----GYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGN 475

  Fly   424 QSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIF 488
            ||...|:..|..|:..|...|:|.|::|::...|.:.:::..:..:...:|::|...    :|:|
Human   476 QSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIR----LGLF 536

  Fly   489 LFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTP----LWP----------FLLRAFMELMLGIC 539
            ..:|.:..|:::..:.||..|...|  ....|.|    |.|          |:|:.||.|::||.
Human   537 TVLYTVPAAVVVACLFYEQHNRPRW--EATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGIT 599

  Fly   540 CFAWVLGPSISTLYKRQVSNGKMVKH----------TSAGAATGHLDGHSSSRG 583
            ...||.             :||.::.          .|.|||.|...|.:::.|
Human   600 SGVWVW-------------SGKTLESWRSLCTRCCWASKGAAVGGGAGATAAGG 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	50/147 (34%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	85/371 (23%)
FZD8	NP_114072.1	CRD_FZ8	31..155	CDD:143570	48/130 (37%)
		Palmitate-binding groove. /evidence=ECO:0000250	71..78		3/6 (50%)
		Wnt-binding. /evidence=ECO:0000250	95..100		1/4 (25%)
		Wnt-binding. /evidence=ECO:0000250	147..152		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..226		13/74 (18%)
		7tmF_FZD8	267..618	CDD:320378	89/399 (22%)
		TM helix 1	277..301	CDD:320378	5/24 (21%)
		TM helix 2	310..331	CDD:320378	6/25 (24%)
		TM helix 3	397..419	CDD:320378	11/21 (52%)
		TM helix 4	440..456	CDD:320378	3/15 (20%)
		TM helix 5	478..501	CDD:320378	6/22 (27%)
		TM helix 6	534..556	CDD:320378	6/21 (29%)
		TM helix 7	579..604	CDD:320378	7/24 (29%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	608..613		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	648..668
		PDZ-binding	692..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820