DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz4 and FZD7

DIOPT Version :10

Sequence 1:NP_511068.2 Gene:fz4 / 31659 FlyBaseID:FBgn0027342 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_003498.1 Gene:FZD7 / 8324 HGNCID:4045 Length:574 Species:Homo sapiens


Alignment Length:626 Identity:161/626 - (25%)
Similarity:254/626 - (40%) Gaps:133/626 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LCLLVVILLHPRISKSSTSGNPSASSSSSSPP-------EIPAFRQCETIRIEMCRKIGYNETSM 64
            ||.||:.||            .:.|:.:.:.|       .:|....|:.|.|.:|..|.||:|.:
Human    15 LCALVLALL------------GALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTIL 67

  Fly    65 PNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIR 129
            |||:|:..|.|....:..|.||::..||.:|:.|||:.|.|:||  ....||.|||||||..|..
Human    68 PNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCT--VLDQAIPPCRSLCERARQG 130

  Fly   130 CHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLYGLPGQG----------- 183
            |..::..|||.||..|.|:.||         :.|.||:...|...|..|.||.|           
Human   131 CEALMNKFGFQWPERLRCENFP---------VHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLP 186

  Fly   184 -------IPGGLGGK----LPMDCSGLAK--SHLYVRLPRSGRCAPLCEAD-----ILFTPAEKH 230
                   .||...|:    .|..|....|  .:|..|......|...||..     :.|...|:.
Human   187 DLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERR 251

  Fly   231 LAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVG 292
            .|.:||..|:.......|...:..|..      ..::|....|:|:   |:.||.:.....|::.
Human   252 FARLWVGVWSVLCCASTLFTVLTYLVD------MRRFSYPERPIIFLSGCYFMVAVAHVAGFLLE 310

  Fly   293 RTGTACGTDPQAPNESLLTV-DGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDS 356
            ......   .:..::...|| .|.....|..:|::.|:||||:..||.:|.|.|..     :...
Human   311 DRAVCV---ERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFL-----AAGM 367

  Fly   357 K-GHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACF 420
            | ||..|.:|                    :.:....||.:||.:|..::....||.|.|.|.|:
Human   368 KWGHEAIEAN--------------------SQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCY 412

  Fly   421 VGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGI 485
            ||..|..||:..|..|:|.|...|:..|::|::...|.:.|:::....:  ::|::|...    |
Human   413 VGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT--EKLEKLMVR----I 471

  Fly   486 GIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNT--------------PLWP----FLLRAFM 532
            |:|..:|.:...::|....||.|..:.|..:....|              |:.|    |:::..|
Human   472 GVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLM 536

  Fly   533 ELMLGICCFAWV-LGPSIST---LYKRQVSNGKMVKHTSAG 569
            .:::||....|: .|.::.:   .|.|       :.|:|.|
Human   537 TMIVGITTGFWIWSGKTLQSWRRFYHR-------LSHSSKG 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz4NP_511068.2 CRD_FZ4 43..169 CDD:143557 50/125 (40%)
7tmF_Frizzled_SMO 222..557 CDD:320089 82/361 (23%)
TM helix 1 231..256 CDD:320089 5/24 (21%)
TM helix 2 268..289 CDD:320089 6/23 (26%)
TM helix 3 321..347 CDD:320089 11/25 (44%)
TM helix 4 388..404 CDD:320089 5/15 (33%)
TM helix 5 426..455 CDD:320089 9/28 (32%)
TM helix 6 481..508 CDD:320089 7/26 (27%)
TM helix 7 519..544 CDD:320089 7/42 (17%)
FZD7NP_003498.1 CRD_FZ7 45..169 CDD:143575 52/134 (39%)
7tmF_FZD7 243..573 CDD:320374 85/375 (23%)
TM helix 1 252..277 CDD:320374 5/24 (21%)
TM helix 2 286..307 CDD:320374 5/20 (25%)
TM helix 3 337..363 CDD:320374 11/25 (44%)
TM helix 4 380..396 CDD:320374 5/15 (33%)
TM helix 5 418..447 CDD:320374 9/28 (32%)
TM helix 6 467..494 CDD:320374 8/30 (27%)
TM helix 7 523..548 CDD:320374 5/24 (21%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 552..557 0/4 (0%)
PDZ-binding 572..574
Blue background indicates that the domain is not in the aligned region.

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