DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz4 and FZD7

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_003498.1	Gene:	FZD7 / 8324	HGNCID:	4045	Length:	574	Species:	Homo sapiens

Alignment Length:	626	Identity:	161/626 - (25%)
Similarity:	254/626 - (40%)	Gaps:	133/626 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCLLVVILLHPRISKSSTSGNPSASSSSSSPP-------EIPAFRQCETIRIEMCRKIGYNETSM 64
            ||.||:.||            .:.|:.:.:.|       .:|....|:.|.|.:|..|.||:|.:
Human    15 LCALVLALL------------GALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTIL 67

  Fly    65 PNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIR 129
            |||:|:..|.|....:..|.||::..||.:|:.|||:.|.|:||  ....||.|||||||..|..
Human    68 PNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCT--VLDQAIPPCRSLCERARQG 130

  Fly   130 CHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLYGLPGQG----------- 183
            |..::..|||.||..|.|:.||         :.|.||:...|...|..|.||.|
Human   131 CEALMNKFGFQWPERLRCENFP---------VHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLP 186

  Fly   184 -------IPGGLGGK----LPMDCSGLAK--SHLYVRLPRSGRCAPLCEAD-----ILFTPAEKH 230
                   .||...|:    .|..|....|  .:|..|......|...||..     :.|...|:.
Human   187 DLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERR 251

  Fly   231 LAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVG 292
            .|.:||..|:.......|...:..|..      ..::|....|:|:   |:.||.:.....|::.
Human   252 FARLWVGVWSVLCCASTLFTVLTYLVD------MRRFSYPERPIIFLSGCYFMVAVAHVAGFLLE 310

  Fly   293 RTGTACGTDPQAPNESLLTV-DGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDS 356
            ......   .:..::...|| .|.....|..:|::.|:||||:..||.:|.|.|..     :...
Human   311 DRAVCV---ERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFL-----AAGM 367

  Fly   357 K-GHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACF 420
            | ||..|.:|                    :.:....||.:||.:|..::....||.|.|.|.|:
Human   368 KWGHEAIEAN--------------------SQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCY 412

  Fly   421 VGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGI 485
            ||..|..||:..|..|:|.|...|:..|::|::...|.:.|:::....:  ::|::|...    |
Human   413 VGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT--EKLEKLMVR----I 471

  Fly   486 GIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNT--------------PLWP----FLLRAFM 532
            |:|..:|.:...::|....||.|..:.|..:....|              |:.|    |:::..|
Human   472 GVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLM 536

  Fly   533 ELMLGICCFAWV-LGPSIST---LYKRQVSNGKMVKHTSAG 569
            .:::||....|: .|.::.:   .|.|       :.|:|.|
Human   537 TMIVGITTGFWIWSGKTLQSWRRFYHR-------LSHSSKG 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	50/125 (40%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	78/343 (23%)
FZD7	NP_003498.1	CRD_FZ7	45..169	CDD:143575	52/134 (39%)
		7tmF_FZD7	243..573	CDD:320374	85/375 (23%)
		TM helix 1	253..277	CDD:320374	5/23 (22%)
		TM helix 2	286..307	CDD:320374	5/20 (25%)
		TM helix 3	337..359	CDD:320374	9/21 (43%)
		TM helix 4	380..396	CDD:320374	5/15 (33%)
		TM helix 5	418..441	CDD:320374	7/22 (32%)
		TM helix 6	472..494	CDD:320374	6/21 (29%)
		TM helix 7	523..548	CDD:320374	5/24 (21%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	552..557		0/4 (0%)
		PDZ-binding	572..574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810