DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz4 and FZD4

DIOPT Version :10

Sequence 1:NP_511068.2 Gene:fz4 / 31659 FlyBaseID:FBgn0027342 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_036325.2 Gene:FZD4 / 8322 HGNCID:4042 Length:537 Species:Homo sapiens


Alignment Length:550 Identity:189/550 - (34%)
Similarity:279/550 - (50%) Gaps:93/550 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 RQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCT 108
            |:|:.|||.||:.:|||.|.||||||:|:|||.|..|.||.|||:|.|||||:.|||:.||||||
Human    43 RRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCT 107

  Fly   109 PKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQE 173
            .|..: .||||..:|.||:.||.|||:.|||.||.:|:|.|||.:|:|..|||||||:...|   
Human   108 EKINI-PIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVP--- 168

  Fly   174 QDLYGLPGQGIPGGLGGKLPM----DCSGL-AKSHLYVRLPRSGRCAPLCEADI-LFTPAEKHLA 232
                          |..|.|:    :|..: ..|..|:.:.||..|...|..|. |::.:.|...
Human   169 --------------LPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFT 219

  Fly   233 EIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRT 294
            :||::.||.... ::...||.....|.||.:..:     .|:|:   |:|:.::.:.||..|||.
Human   220 DIWMAVWASLCF-ISTAFTVLTFLIDSSRFSYPE-----RPIIFLSMCYNIYSIAYIVRLTVGRE 278

  Fly   295 GTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGW---------HRDIR 350
            ..:|..:..|  |.:|..:||.|..||.:||:.|:||||:..||.:|.|.|         |..|.
Human   279 RISCDFEEAA--EPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIE 341

  Fly   351 RHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADEL 415
            .||  |..|:                               .||.:||.:|..:::.|.||||||
Human   342 MHS--SYFHI-------------------------------AAWAIPAVKTIVILIMRLVDADEL 373

  Fly   416 LGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAH 480
            .|.|:||||:..||...|..|:|.|.:.|::.:.:|.:...:.:..|:.....:  .:|::|...
Human   374 TGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKT--DKLERLMVK 436

  Fly   481 SSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTPLWPFLLRAFMELMLGICCFAWVL 545
                ||:|..:|.:....::....||.:|..::..|.| ::.:...:|:.||.|::||....|:.
Human   437 ----IGVFSVLYTVPATCVIACYFYEISNWALFRYSAD-DSNMAVEMLKIFMSLLVGITSGMWIW 496

  Fly   546 GPSISTLY------KRQVSNGKMVKHTSAG 569
              |..||:      .|.|::|| ||....|
Human   497 --SAKTLHTWQKCSNRLVNSGK-VKREKRG 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz4NP_511068.2 CRD_FZ4 43..169 CDD:143557 75/124 (60%)
7tmF_Frizzled_SMO 222..557 CDD:320089 96/353 (27%)
TM helix 1 231..256 CDD:320089 6/24 (25%)
TM helix 2 268..289 CDD:320089 5/23 (22%)
TM helix 3 321..347 CDD:320089 13/34 (38%)
TM helix 4 388..404 CDD:320089 5/15 (33%)
TM helix 5 426..455 CDD:320089 8/28 (29%)
TM helix 6 481..508 CDD:320089 6/26 (23%)
TM helix 7 519..544 CDD:320089 6/24 (25%)
FZD4NP_036325.2 CRD_FZ4 42..167 CDD:143557 75/124 (60%)
7tmF_FZD4 209..509 CDD:320166 95/349 (27%)
TM helix 1 218..243 CDD:320166 6/25 (24%)
TM helix 2 252..273 CDD:320166 5/25 (20%)
TM helix 3 303..329 CDD:320166 13/25 (52%)
TM helix 4 346..362 CDD:320166 6/46 (13%)
TM helix 5 384..413 CDD:320166 8/28 (29%)
TM helix 6 433..460 CDD:320166 7/30 (23%)
TM helix 7 470..495 CDD:320166 7/25 (28%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 499..504 2/4 (50%)
PDZ-binding 535..537
Blue background indicates that the domain is not in the aligned region.

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