Protein Alignment fz4 and FZD1

DIOPT Version :9

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_003496.1
• Gene: FZD1 / 8321
• HGNCID: 4038
• Length: 647
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 165/644 - (25%)
• Similarity: 261/644 - (40%)
• Gaps: 136/644 - (21%)

  Fly     7 LCLLVVILLHPRI----SKSSTSG---NPSASSSSSSPPE---------------IPAFRQCETI 49
            |.||:.:|..|.:    ::::..|   .|........||:               :|....|:.|
Human    55 LLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPI 119

  Fly    50 RIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVH 114
            .|.:|..|.||:|.||||:|:..|.|....:..|.||::..||::||.|||:.|.|:||  ....
Human   120 SIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCT--VLEQ 182

  Fly   115 AIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQD---- 175
            |:.|||||||..|..|..::..|||.||..|.|:|||         :.|.|||...|...|
Human   183 ALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFP---------VHGAGELCVGQNTSDKGTP 238

  Fly   176 -------------LYGLPGQ--GIPGGLG----GKLPMDCSGLAKSHLYVRLPRSGR--CAPLCE 219
                         .:|..|.  |.|||.|    ||  ..|....|...|:.....|.  |...||
Human   239 TPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGK--FSCPRALKVPSYLNYHFLGEKDCGAPCE 301

  Fly   220 AD-----ILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW--- 276
            ..     :.|.|.|...:..|:..|:.......|...:..|..      ..::|....|:|:
Human   302 PTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVD------MRRFSYPERPIIFLSG 360

  Fly   277 CHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVL 341
            |:..|.:.:...|:: .....| .|..|.:.:.....|.....|..:|:|.|:|.||:..||.:|
Human   361 CYTAVAVAYIAGFLL-EDRVVC-NDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVIL 423

  Fly   342 CLGWHRDIRRHSPDSK-GHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVI 405
            .|.|..     :...| ||..|.:|                    :.:....||.:||.:|..::
Human   424 SLTWFL-----AAGMKWGHEAIEAN--------------------SQYFHLAAWAVPAIKTITIL 463

  Fly   406 VARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSV 470
            ....||.|.|.|.||||..:..||:..|..|:|.|...|:..|::|::...|.:.|:::....:
Human   464 ALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT- 527

  Fly   471 QQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWL--------------------- 514
             ::|::|...    ||:|..:|.:...:::....||.|..|.|.
Human   528 -EKLEKLMVR----IGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAG 587

  Fly   515 GSGDTNTPLWP----FLLRAFMELMLGICCFAWV-LGPSISTLYK--RQVSNGKMVKHT 566
            |....:.|:.|    |:::..|.|::||....|: .|.::::..|  .:::|.|..:.|
Human   588 GGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETT 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	53/125 (42%)
		7tm_4	223..544	CDD:304433	78/349 (22%)
FZD1	NP_003496.1	CRD_FZ1	112..238	CDD:143574	55/136 (40%)
		Frizzled	310..634	CDD:279827	81/362 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810