Sequence 1: | NP_511068.2 | Gene: | fz4 / 31659 | FlyBaseID: | FBgn0027342 | Length: | 705 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_003459.2 | Gene: | FZD5 / 7855 | HGNCID: | 4043 | Length: | 585 | Species: | Homo sapiens |
Alignment Length: | 643 | Identity: | 167/643 - (25%) |
---|---|---|---|
Similarity: | 272/643 - (42%) | Gaps: | 113/643 - (17%) |
- Green bases have known domain annotations that are detailed below.
Fly 3 PTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNL 67
Fly 68 VGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVH-AIGPCRSLCESVRIRCH 131
Fly 132 PVLQGFGFPWPPALDCDKFP-RENNHETMCME---GPGELHQPQ---QEQDLYGLPGQGIPGG-- 187
Fly 188 -LGGKLPMDCSG-----LAKSH-LY--VRLPRSGRCAPLCEADILFTPAEKHLAEIWVSTWAYAA 243
Fly 244 LGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAP 305
Fly 306 NESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSP 370
Fly 371 AKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVAT 435
Fly 436 PVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLL 500
Fly 501 LAVIYEFANIDVWLGS-------GDTNTP-----LWPFLLRAFMELMLGICCFAWVLGPSISTLY 553
Fly 554 KRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSP 611 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
fz4 | NP_511068.2 | CRD_FZ4 | 43..169 | CDD:143557 | 47/130 (36%) |
7tm_4 | 223..544 | CDD:304433 | 80/335 (24%) | ||
FZD5 | NP_003459.2 | TM helix 5 | 397..426 | CDD:320377 | 7/28 (25%) |
TM helix 6 | 446..473 | CDD:320377 | 8/30 (27%) | ||
TM helix 7 | 496..521 | CDD:320377 | 7/24 (29%) | ||
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 525..530 | 0/4 (0%) | |||
PDZ-binding | 583..585 | ||||
CRD_FZ5 | 29..156 | CDD:143569 | 48/135 (36%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 156..179 | 5/22 (23%) | |||
7tmF_FZD5 | 225..535 | CDD:320377 | 82/351 (23%) | ||
TM helix 1 | 234..259 | CDD:320377 | 5/25 (20%) | ||
TM helix 2 | 268..289 | CDD:320377 | 7/25 (28%) | ||
TM helix 3 | 316..342 | CDD:320377 | 13/38 (34%) | ||
TM helix 4 | 359..375 | CDD:320377 | 3/15 (20%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D237456at33208 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
3 | 2.820 |