DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fz4 and FZD5

DIOPT Version :9

Sequence 1:NP_511068.2 Gene:fz4 / 31659 FlyBaseID:FBgn0027342 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_003459.2 Gene:FZD5 / 7855 HGNCID:4043 Length:585 Species:Homo sapiens


Alignment Length:643 Identity:167/643 - (25%)
Similarity:272/643 - (42%) Gaps:113/643 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 PTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNL 67
            |..:|.||:..|:            ..|:::|.:|       .|:.|.:.|||.||||.|.|||.
Human     9 PPSLLLLLLAQLV------------GRAAAASKAP-------VCQEITVPMCRGIGYNLTHMPNQ 54

  Fly    68 VGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVH-AIGPCRSLCESVRIRCH 131
            ..::.|.:....:..|.||:|..||..|:.|||:.|.|:|.|  ..| .:.||||:||..:..|.
Human    55 FNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLP--DYHKPLPPCRSVCERAKAGCS 117

  Fly   132 PVLQGFGFPWPPALDCDKFP-RENNHETMCME---GPGELHQPQ---QEQDLYGLPGQGIPGG-- 187
            |:::.:||.||..:.||:.| ...:.|.:||:   .......|:   .:..|.|.||....||  
Human   118 PLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGGEC 182

  Fly   188 -LGGKLPMDCSG-----LAKSH-LY--VRLPRSGRCAPLCEADILFTPAEKHLAEIWVSTWAYAA 243
             .||.....|..     |.:|| ||  ||..:...||..|... .|:..|:..|..|:..|:...
Human   183 PAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQP-SFSADERTFATFWIGLWSVLC 246

  Fly   244 LGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAP 305
            . ::...||.....|..|....:     .|:|:   |:..|:||:.||.:||....||..:    
Human   247 F-ISTSTTVATFLIDMERFRYPE-----RPIIFLSACYLCVSLGFLVRLVVGHASVACSRE---- 301

  Fly   306 NESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSP 370
             .:.:..:....|.|..|||:.|:||||:..||.:|.|.|             .:.....:|...
Human   302 -HNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTW-------------FLAAGMKWGNEA 352

  Fly   371 AKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVAT 435
            .    |..||       :....||.:|:.::...:....||.|.:.|.|:||||:..:|:..|..
Human   353 I----AGYAQ-------YFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLG 406

  Fly   436 PVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLL 500
            |:..|.:.|::.|::|::...|.:.:::.....:  .:|::|...    ||||..:|.:..::::
Human   407 PLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKT--DKLEKLMIR----IGIFTLLYTVPASIVV 465

  Fly   501 LAVIYEFANIDVWLGS-------GDTNTP-----LWPFLLRAFMELMLGICCFAWVLGPSISTLY 553
            ...:||....:.|..:       .||..|     .|..:|:.||.|::||....|:........:
Human   466 ACYLYEQHYRESWEAALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESW 530

  Fly   554 KRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSP 611
            :|..|      ........||..|.:.:.|.:...::.:..    ||.      ||.|
Human   531 RRFTS------RCCCRPRRGHKSGGAMAAGDYPEASAALTG----RTG------PPGP 572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz4NP_511068.2 CRD_FZ4 43..169 CDD:143557 47/130 (36%)
7tm_4 223..544 CDD:304433 80/335 (24%)
FZD5NP_003459.2 TM helix 5 397..426 CDD:320377 7/28 (25%)
TM helix 6 446..473 CDD:320377 8/30 (27%)
TM helix 7 496..521 CDD:320377 7/24 (29%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 525..530 0/4 (0%)
PDZ-binding 583..585
CRD_FZ5 29..156 CDD:143569 48/135 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 156..179 5/22 (23%)
7tmF_FZD5 225..535 CDD:320377 82/351 (23%)
TM helix 1 234..259 CDD:320377 5/25 (20%)
TM helix 2 268..289 CDD:320377 7/25 (28%)
TM helix 3 316..342 CDD:320377 13/38 (34%)
TM helix 4 359..375 CDD:320377 3/15 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D237456at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.