DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz4 and SFRP1

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_003003.3	Gene:	SFRP1 / 6422	HGNCID:	10776	Length:	314	Species:	Homo sapiens

Alignment Length:	156	Identity:	52/156 - (33%)
Similarity:	82/156 - (52%)	Gaps:	14/156 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ISKSSTSGNPSASSSSSSPP---EIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTL 80
            :|..|..|...:....:.||   :|||       .:.:|..:||.:..:|||:.:|...:|:...
Human    37 VSFQSDIGPYQSGRFYTKPPQCVDIPA-------DLRLCHNVGYKKMVLPNLLEHETMAEVKQQA 94

  Fly    81 QTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPAL 145
            .::.||:..:|.:..::|||:.:.|:|..: |::   |||.|||:||..|.||:|.|||.||..|
Human    95 SSWVPLLNKNCHAGTQVFLCSLFAPVCLDR-PIY---PCRWLCEAVRDSCEPVMQFFGFYWPEML 155

  Fly   146 DCDKFPRENNHETMCMEGPGELHQPQ 171
            .|||||..:....|......|..:||
Human   156 KCDKFPEGDVCIAMTPPNATEASKPQ 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	42/125 (34%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433
SFRP1	NP_003003.3	CRD_SFRP1	52..175	CDD:143552	46/133 (35%)
SFRP1	NP_003003.3	NTR_Sfrp1_like	183..306	CDD:239635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810