Protein Alignment fz4 and Fzd1

DIOPT Version :10

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_067089.2
• Gene: Fzd1 / 58868
• RGDID: 61916
• Length: 642
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 165/639 - (25%)
• Similarity: 259/639 - (40%)
• Gaps: 130/639 - (20%)

  Fly     7 LCLLVVILLHPRI--SKSSTSGNPSASSSSSSPP----------------EIPAFRQCETIRIEM 53
            |.||:.:|..|.:  .::..:|..|.....:.||                .||....|:.|.|.:
  Rat    54 LLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQGGQQYNGERGISIPDHGYCQPISIPL 118

  Fly    54 CRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGP 118
            |..|.||:|.||||:|:..|.|....:..|.||::..||::||.|||:.|.|:||  ....|:.|
  Rat   119 CTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCT--VLEQALPP 181

  Fly   119 CRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLYGLPGQ- 182
            ||||||..|..|..::..|||.||..|.|:|||         :.|.|||...|...| .|.|..
  Rat   182 CRSLCERARQGCEALMNKFGFQWPDTLKCEKFP---------VHGAGELCVGQNTSD-KGTPTPS 236

  Fly   183 -------------------GIPGGLG----GKLPMDCSGLAKSHLYVRLPRSGRCAPLCEAD--- 221
                               |.|||.|    ||.....:....|:|.........|...||..
  Rat   237 LLPEFWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKVY 301

  Fly   222 --ILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMV 281
              :.|.|.|...:..|:..|:.......|...:..|..      ..::|....|:|:   |:..|
  Rat   302 GLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVD------MRRFSYPERPIIFLSGCYTAV 360

  Fly   282 TLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWH 346
            .:.:...|:: .....| .|..|.:.:.....|.....|..:|:|.|:|.||:..||.:|.|.|.
  Rat   361 AVAYIAGFLL-EDRVVC-NDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWF 423

  Fly   347 RDIRRHSPDSK-GHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFV 410
            .     :...| ||..|.:|                    :.:....||.:||.:|..::....|
  Rat   424 L-----AAGMKWGHEAIEAN--------------------SQYFHLAAWAVPAIKTITILALGQV 463

  Fly   411 DADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQ 475
            |.|.|.|.||||..:..||:..|..|:|.|...|:..|::|::...|.:.|:::....:  ::|:
  Rat   464 DGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT--EKLE 526

  Fly   476 QLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVW-------------------LGSGDT-- 519
            :|...    ||:|..:|.:...:::....||.|..|.|                   .|.|..
  Rat   527 KLMVR----IGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPP 587

  Fly   520 NTPLWP----FLLRAFMELMLGICCFAWV-LGPSISTLYK--RQVSNGKMVKHT 566
            :.|:.|    |:::..|.|::||....|: .|.::::..|  .:::|.|..:.|
  Rat   588 HPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETT 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	53/125 (42%)
		7tmF_Frizzled_SMO	222..557	CDD:320089	82/366 (22%)
		TM helix 1	231..256	CDD:320089	3/24 (13%)
		TM helix 2	268..289	CDD:320089	5/23 (22%)
		TM helix 3	321..347	CDD:320089	11/25 (44%)
		TM helix 4	388..404	CDD:320089	5/15 (33%)
		TM helix 5	426..455	CDD:320089	9/28 (32%)
		TM helix 6	481..508	CDD:320089	6/26 (23%)
		TM helix 7	519..544	CDD:320089	7/30 (23%)
Fzd1	NP_067089.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..99		4/24 (17%)
		CRD_FZ1	107..233	CDD:143574	56/137 (41%)
		7tmF_FZD1	294..641	CDD:320375	86/385 (22%)
		TM helix 1	313..338	CDD:320375	3/24 (13%)
		TM helix 2	347..368	CDD:320375	4/20 (20%)
		TM helix 3	398..424	CDD:320375	11/25 (44%)
		TM helix 4	441..457	CDD:320375	5/15 (33%)
		TM helix 5	479..508	CDD:320375	9/28 (32%)
		TM helix 6	528..555	CDD:320375	7/30 (23%)
		TM helix 7	591..616	CDD:320375	6/24 (25%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	620..625		0/4 (0%)
		PDZ-binding	640..642		1/2 (50%)