Protein Alignment fz4 and Fzd1

DIOPT Version :9

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_067089.2
• Gene: Fzd1 / 58868
• RGDID: 61916
• Length: 642
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 165/639 - (25%)
• Similarity: 259/639 - (40%)
• Gaps: 130/639 - (20%)

  Fly     7 LCLLVVILLHPRI--SKSSTSGNPSASSSSSSPP----------------EIPAFRQCETIRIEM 53
            |.||:.:|..|.:  .::..:|..|.....:.||                .||....|:.|.|.:
  Rat    54 LLLLLWLLEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQGGQQYNGERGISIPDHGYCQPISIPL 118

  Fly    54 CRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGP 118
            |..|.||:|.||||:|:..|.|....:..|.||::..||::||.|||:.|.|:||  ....|:.|
  Rat   119 CTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCT--VLEQALPP 181

  Fly   119 CRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLYGLPGQ- 182
            ||||||..|..|..::..|||.||..|.|:|||         :.|.|||...|...| .|.|..
  Rat   182 CRSLCERARQGCEALMNKFGFQWPDTLKCEKFP---------VHGAGELCVGQNTSD-KGTPTPS 236

  Fly   183 -------------------GIPGGLG----GKLPMDCSGLAKSHLYVRLPRSGRCAPLCEAD--- 221
                               |.|||.|    ||.....:....|:|.........|...||..
  Rat   237 LLPEFWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKVY 301

  Fly   222 --ILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMV 281
              :.|.|.|...:..|:..|:.......|...:..|..      ..::|....|:|:   |:..|
  Rat   302 GLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVD------MRRFSYPERPIIFLSGCYTAV 360

  Fly   282 TLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWH 346
            .:.:...|:: .....| .|..|.:.:.....|.....|..:|:|.|:|.||:..||.:|.|.|.
  Rat   361 AVAYIAGFLL-EDRVVC-NDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWF 423

  Fly   347 RDIRRHSPDSK-GHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFV 410
            .     :...| ||..|.:|                    :.:....||.:||.:|..::....|
  Rat   424 L-----AAGMKWGHEAIEAN--------------------SQYFHLAAWAVPAIKTITILALGQV 463

  Fly   411 DADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQ 475
            |.|.|.|.||||..:..||:..|..|:|.|...|:..|::|::...|.:.|:::....:  ::|:
  Rat   464 DGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT--EKLE 526

  Fly   476 QLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVW-------------------LGSGDT-- 519
            :|...    ||:|..:|.:...:::....||.|..|.|                   .|.|..
  Rat   527 KLMVR----IGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPP 587

  Fly   520 NTPLWP----FLLRAFMELMLGICCFAWV-LGPSISTLYK--RQVSNGKMVKHT 566
            :.|:.|    |:::..|.|::||....|: .|.::::..|  .:::|.|..:.|
  Rat   588 HPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETT 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	53/125 (42%)
		7tm_4	223..544	CDD:304433	79/349 (23%)
Fzd1	NP_067089.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..99		4/24 (17%)
		CRD_FZ1	107..233	CDD:143574	56/137 (41%)
		Frizzled	305..629	CDD:279827	82/362 (23%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	620..625		0/4 (0%)
		PDZ-binding	640..642		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810