Protein Alignment fz4 and Fzd2

DIOPT Version :9

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_065256.1
• Gene: Fzd2 / 57265
• MGIID: 1888513
• Length: 570
• Species: Mus musculus
• Alignment Length: 589
• Identity: 162/589 - (27%)
• Similarity: 251/589 - (42%)
• Gaps: 112/589 - (19%)

  Fly     9 LLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQ 73
            ||:.:||.|....:...|....|        ||....|:.|.|.:|..|.||:|.||||:|:..|
Mouse    15 LLLPLLLLPAAGPAQFHGEKGIS--------IPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQ 71

  Fly    74 TDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFG 138
            .|....:..|.||::..||.:|:.|||:.|.|:||  ....||.||||:||..|..|..::..||
Mouse    72 EDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCT--VLEQAIPPCRSICERARQGCEALMNKFG 134

  Fly   139 FPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLY------GL-PGQ-GIPGGLGG----- 190
            |.||..|.|:.||| :..|.:|:   |:.|.......|.      || ||. |.|||.||
Mouse   135 FQWPERLRCEHFPR-HGAEQICV---GQNHSEDGAPALLTTAPPSGLQPGAGGTPGGPGGGGSPP 195

  Fly   191 -----KLPMDCSGLAK--SHLYVRLPRSGRCAPLCE-----ADILFTPAEKHLAEIWVSTWAYAA 243
                 :.|..|..:.|  |:|..:......||..||     ..:.|:..|...|.:|:.||:...
Mouse   196 RYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLC 260

  Fly   244 LGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAP 305
            .. :...||.....|..|....:     .|:|:   |:.||::.:...|:: :....|
Mouse   261 CA-STFFTVTTYLVDMQRFRYPE-----RPIIFLSGCYTMVSVAYIAGFVL-QERVVC------- 311

  Fly   306 NESL------LTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSK-GHVVIP 363
            ||..      ..|.|.....|..:|:|.|:|.||:..||.:|.|.|..     :...| ||..|.
Mouse   312 NERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFL-----AAGMKWGHEAIE 371

  Fly   364 SNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKA 428
            :|                    :.:....||.:||.:|..::....:|.|.|.|.||||..|...
Mouse   372 AN--------------------SQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDP 416

  Fly   429 LQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYG 493
            |:..|..|:|.|...|:..|::|::...|.:.|:::....:  ::|::|...    ||:|..:|.
Mouse   417 LRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT--EKLERLMVR----IGVFSVLYT 475

  Fly   494 LACAMLLLAVIYEFANIDVWLGSGDTN-------------TP-LWP----FLLRAFMELMLGICC 540
            :...:::....||.|..:.|..|..:.             || :.|    ::::..|.|::||..
Mouse   476 VPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITS 540

  Fly   541 FAWV 544
            ..|:
Mouse   541 GFWI 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	51/125 (41%)
		7tm_4	223..544	CDD:304433	80/348 (23%)
Fzd2	NP_065256.1	CRD_FZ2	40..166	CDD:143573	52/131 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..194		11/27 (41%)
		Frizzled	240..557	CDD:279827	81/350 (23%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	548..553
		PDZ-binding	568..570

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810