DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and fzd3b

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001074070.1	Gene:	fzd3b / 567746	ZFINID:	ZDB-GENE-070122-1	Length:	667	Species:	Danio rerio

Alignment Length:	693	Identity:	167/693 - (24%)
Similarity:	267/693 - (38%)	Gaps:	153/693 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPK 110
            ||:|.:.||:.:.||.|.||||:.:..|......::.|.|::...||..|:.||||.|.|:|...
Zfish    40 CESIGLRMCQDLPYNNTFMPNLLNHYDQQTAALAMEPFHPMVNLQCSPDLRPFLCALYAPVCMEY 104

  Fly   111 APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFP-----RENNHETMCMEGPGELHQP 170
            ..|..  ||||||...:..|..::..||..||..::|.:||     .....:.:.::.|.: ..|
Zfish   105 GRVSL--PCRSLCHHAKRDCQKLMDMFGVTWPEEMECTRFPDCDESYPRAEDLLVIDDPTD-QSP 166

  Fly   171 QQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLCEADILFTPAEKHLAEIW 235
            ...|..||.   ..|..|  |:..|   |..:.|.||     .|:|.| .::.|...|...|..:
Zfish   167 MSVQRDYGF---WCPREL--KMEPD---LGYTFLGVR-----DCSPPC-PNMYFRREELTFARYF 217

  Fly   236 VSTWAYAALGLALVATVCLLAS---------DGSRLASAKWSRLLSPLIW---CHNMVTLGWAVR 288
            :          .:|:.|||.|:         |.:|....:     .|:|:   |:.||:|.:.:.
Zfish   218 I----------GVVSIVCLSATLFTFLTFLIDVTRFRYPE-----RPIIFYAVCYMMVSLVFFLG 267

  Fly   289 FMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHS 353
            |:: ....||.:......::.....|..|.:|..:|::.|:|.||...||.:|.:.|..
Zfish   268 FLL-EDRVACNSANPGQYKTSTVTQGSHNKACTLLFMVLYFFTMAGSVWWVILTITWFL------ 325

  Fly   354 PDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGA 418
                  ..:|.  .||.|....|......          |||:|...|.|::....::.|.:.|.
Zfish   326 ------AAVPK--WGSEAIEKKALLFHAS----------AWGIPGMLTIALLALNKIEGDNISGV 372

  Fly   419 CFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTK-EI-LRNSNALSVQQQLQQLSAHS 481
            ||||....:.|:..|..|:....:.|...|::|.:...|.: || |...|    |::|.:....
Zfish   373 CFVGVYDVQTLRWFVLAPLCLDVLVGVSLLLAGIVALNRVRMEIPLEKEN----QEKLVKFMIR- 432

  Fly   482 SSGIGIFLFIYGLACAMLLLAVIYEFANIDVW-----------------LGSGDTNTP-LWPFLL 528
               ||:|..:|.:....::...:||.....||                 .....|:.| |..||:
Zfish   433 ---IGVFSVLYLVPLLTVVGCYLYEQTYRSVWETTWVQERCREYHIPCPFKVEQTSRPDLVLFLI 494

  Fly   529 RAFMELMLGI----------CCFAWV-------LGPSISTLYKRQV------------------- 557
            :..|.|::||          .||.|.       ...|.:....|||
Zfish   495 KYLMVLVVGIPSVFWVGSKKTCFEWAGFFHGRRRKDSGAVHESRQVLQDPDFAQSLLRDPNTPIV 559

  Fly   558 --SNGKMVKHTSAGAATGHL----DGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSPYK-LK 615
              |.|...:.||..|::.||    |..|.:...|:..     |:||............|.:: |:
Zfish   560 RKSRGTSTQGTSTHASSTHLAMLDDVRSKASSVHSKS-----SFHSSLQRSRDERFTSSTHRGLE 619

  Fly   616 TSPGTGSISLNQMSNYSLGR-SVHHQQRHSPHHHHHQQQQHHQ 657
            ..|..|  ||.::::....| |...:..|:|.....||::..|
Zfish   620 ERPAYG--SLPRLTDQQPSRHSSTPELSHTPAVSESQQEEQEQ 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	41/127 (32%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	80/362 (22%)
fzd3b	NP_001074070.1	CRD_FZ	36..162	CDD:382974	40/123 (33%)
		7tmF_FZD3	204..524	CDD:320161	81/367 (22%)
		TM helix 1	213..238	CDD:320161	6/34 (18%)
		TM helix 2	247..268	CDD:320161	6/25 (24%)
		TM helix 3	299..325	CDD:320161	9/25 (36%)
		TM helix 4	342..364	CDD:320161	6/31 (19%)
		TM helix 5	378..403	CDD:320161	4/24 (17%)
		TM helix 6	431..456	CDD:320161	6/28 (21%)
		TM helix 7	485..510	CDD:320161	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810