DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and fzd9a

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_003198734.2	Gene:	fzd9a / 557447	ZFINID:	ZDB-GENE-060531-77	Length:	581	Species:	Danio rerio

Alignment Length:	619	Identity:	174/619 - (28%)
Similarity:	280/619 - (45%)	Gaps:	116/619 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SSSPPEIPAF-------RQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDC 91
            ::|..||.|:       .:||.|.|.||:.||||.|.||||:..|.|.:....|..||||::|.|
Zfish    17 AASTLEIGAYDLEHGRPGKCEPITIPMCQGIGYNMTRMPNLLNYESQEEASIKLNEFAPLVKYGC 81

  Fly    92 SSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNH 156
            ...|:.|||:.|||||..:... :|..||.:||..|.||.|:::.|.|.||.:|||.|.|..|:.
Zfish    82 DIHLQFFLCSLYVPMCAEQVSA-SIPACRPMCEQARQRCSPIMEQFSFSWPDSLDCSKLPTNNDP 145

  Fly   157 ETMCMEGPGELHQPQQEQDLYGLPGQGI---------PGGLGGKLPMDCSGLAKSHLYVRLPRSG 212
            ..:|:|.|....||:.::      |:|:         |..:.|::............:..:.:|.
Zfish   146 NALCIEAPENDTQPETKK------GEGMLPVPPRSRQPTTVSGRISSISQSCENPEKFQYVDKSE 204

  Fly   213 RCAPLC--EADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSP-- 273
            .|||.|  ..|:.::..:|..|.||:..|          :|:|.:::     |....:.||.|
Zfish   205 SCAPRCTPTVDVYWSRQDKDFAFIWMVVW----------STLCFVST-----AFTVLTFLLDPQR 254

  Fly   274 ----------LIWCHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTV-DGLSNASCASVFLMR 327
                      |..|:|:.::.:.:|.:.|....||..:    |..|..: :||.:..|..|||:.
Zfish   255 FQYPERPIIFLSMCYNIYSVAFIIRSVAGAENIACDRE----NGELYIIREGLESTGCTIVFLIL 315

  Fly   328 YYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFV 392
            ||||||:..||.:|.|.|.....|    ..||..|.::                    :::....
Zfish   316 YYFGMASSIWWVILTLTWFLAAGR----KWGHEAIEAH--------------------SSYFHMA 356

  Fly   393 AWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCR 457
            |||:||.:|..::..|.|..|||.|.|:||:....||...|..|:.||.|.|:..:::|::....
Zfish   357 AWGIPAVKTIVILTMRKVAGDELTGLCYVGSMDSSALTGFVLIPLSCYLIVGTSFILTGFVALFH 421

  Fly   458 TKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWL-------- 514
            .::|::.....:  ::|::|...    ||:|..:|.:...::::...||..|::.|.
Zfish   422 IRKIMKTGGTNT--EKLEKLMVK----IGVFSILYTVPATIVIICYFYERLNMEYWKFRALENKC 480

  Fly   515 ----------GSGDTNTP-LWPFLLRAFMELMLGICCFAWVLGPSISTLYKRQ-VSNGKMVKHTS 567
                      .|.|::.| :..|:|:.||.|::||....||.  |..||...| :.|.::
Zfish   481 VSFPGRRSDDCSLDSSVPTVAVFMLKIFMSLVVGITSGVWVW--SSKTLQTWQGLCNRRL----- 538

  Fly   568 AGAATGHLDGHS-SSRGSHAACNSTVVSYHSVRT 600
             |..|.|....| |...||....:..|:.|..:|
Zfish   539 -GVQTSHKPCSSVSCSNSHCHYKAPAVTVHMNKT 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	55/132 (42%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	86/352 (24%)
fzd9a	XP_003198734.2	CRD_FZ	32..157	CDD:321937	55/125 (44%)
		7tmF_FZD9	216..535	CDD:320164	92/369 (25%)
		TM helix 1	225..250	CDD:320164	7/39 (18%)
		TM helix 2	259..280	CDD:320164	3/20 (15%)
		TM helix 3	309..335	CDD:320164	14/25 (56%)
		TM helix 4	352..368	CDD:320164	6/15 (40%)
		TM helix 5	390..420	CDD:320164	9/29 (31%)
		TM helix 6	439..466	CDD:320164	7/30 (23%)
		TM helix 7	496..521	CDD:320164	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920