Protein Alignment fz4 and fzd7

DIOPT Version :9

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_001016741.1
• Gene: fzd7 / 549495
• XenbaseID: XB-GENE-483731
• Length: 548
• Species: Xenopus tropicalis
• Alignment Length: 601
• Identity: 161/601 - (26%)
• Similarity: 248/601 - (41%)
• Gaps: 115/601 - (19%)

  Fly     9 LLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQ 73
            ||..:||.|..|.....|....|        :|....|:.|.|.:|..|.||:|.||||:|:..|
 Frog     7 LLFCLLLQPSPSAQQYHGEKGIS--------VPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQ 63

  Fly    74 TDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFG 138
            .|....:..|.||::..||.:|:.|||:.|.|:||  ....||.|||||||..|..|..::..||
 Frog    64 EDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCT--VLEQAIPPCRSLCERARQGCEALMNKFG 126

  Fly   139 FPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLYGLPGQGIPGGLGGK----LP------ 193
            |.||..|.|:.||         :.|.||:...|...|       ..|.|...:    ||
 Frog   127 FQWPERLRCENFP---------IHGAGEICVGQNTSD-------NSPSGPTARPTPYLPDSITFH 175

  Fly   194 ------MDCSGLAK--SHLYVRLPRSGRCAPLCEAD-----ILFTPAEKHLAEIWVSTWAYAALG 245
                  ..|....|  .:|..|......|...||..     :.|...|...|.:||..||... |
 Frog   176 PHLNRDFTCPRQLKVPPYLGYRFLGEKDCGAPCEPGKANGLMYFKEEEVRFARLWVGIWAILC-G 239

  Fly   246 LALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAPNE 307
            ::.:.||.....|..|.:..:     .|:|:   |:.||.:.:...|::...|...   .:...:
 Frog   240 ISTLFTVLTYLVDMRRFSYPE-----RPIIFLSGCYFMVAVAYTAGFLLEERGVCV---ERFSED 296

  Fly   308 SLLTV-DGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSK-GHVVIPSNFGGSP 370
            |..|| .|.....|..:|::.|:||||:..||.:|.|.|..     :...| ||..|.:|
 Frog   297 SYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFL-----AAGMKWGHEAIEAN----- 351

  Fly   371 AKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVAT 435
                           :.:....||.:||.:|..::....||.|.|.|.|:||..|..:|:..|..
 Frog   352 ---------------SQYFHLAAWAVPAVKTITILAMGQVDGDILSGVCYVGINSVDSLRGFVLA 401

  Fly   436 PVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLL 500
            |:|.|...|:..|::|::...|.:.|:::....:  ::|::|...    ||:|..:|.:...::|
 Frog   402 PLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT--EKLEKLMVR----IGVFSVMYTVPATIVL 460

  Fly   501 LAVIYEFANIDVWLGSGDTNT--------------PLWP----FLLRAFMELMLGICCFAWVLGP 547
            ....||.|..|.|..:....|              |:.|    |:::..|.:::||....|:...
 Frog   461 ACYFYEQAFRDTWEKTWLVQTCKGFAVPCPNYNFAPMSPDFTVFMIKYLMTMIVGITSSFWIWSG 525

  Fly   548 SISTLYKR---QVSNG 560
            .....::|   ::|||
 Frog   526 KTLQSWRRFYHRLSNG 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	51/125 (41%)
		7tm_4	223..544	CDD:304433	83/343 (24%)
fzd7	NP_001016741.1	CRD_FZ7	32..156	CDD:143575	53/141 (38%)
		Frizzled	218..536	CDD:279827	85/357 (24%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	526..531		0/4 (0%)
		PDZ-binding. /evidence=ECO:0000255	546..548

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910