Protein Alignment fz4 and fzd10

DIOPT Version :10

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_001005669.1
• Gene: fzd10 / 448162
• XenbaseID: XB-GENE-480379
• Length: 585
• Species: Xenopus tropicalis
• Alignment Length: 692
• Identity: 183/692 - (26%)
• Similarity: 287/692 - (41%)
• Gaps: 171/692 - (24%)

  Fly     1 MKPTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMP 65
            ::.|.:|.:|...|               .|..||..|:.....:|:.|.|.||:.||||.|.||
 Frog     9 LRRTALLLVLAAAL---------------CSGISSINPDRSGDGRCQPIEIPMCKDIGYNMTRMP 58

  Fly    66 NLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPK--APVHAIGPCRSLCESVRI 128
            ||:|:|.|.:....|..||||:||.|.|.||.|||:.|.||||.:  .|:.|   ||.:||..|:
 Frog    59 NLMGHENQKEAAIQLHEFAPLVEYGCHSHLKFFLCSLYAPMCTEQVSTPIPA---CRVMCEQARL 120

  Fly   129 RCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGE--------------LHQPQQEQDLYGL 179
            :|.|:::.|.|.||.:|||.|.|.:|:...:|||.|..              :.:||:
 Frog   121 KCSPIMEQFNFKWPDSLDCSKLPNKNDPNYLCMEAPNNGSEEAPRGSSMLPPIFRPQR------- 178

  Fly   180 PGQG---IPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLCEA--DILFTPAEKHLAEIWVSTW 239
            |..|   .|....|:...:.||  |.|   .:.:|..|||||.:  |:.::..:|..|.||::.|
 Frog   179 PNSGHEIYPKDPTGRTTCENSG--KFH---HVEKSASCAPLCSSAVDVYWSKDDKKFAFIWIAIW 238

  Fly   240 AYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTD 301
            :.... .:...||.....|..|....:     .|:|:   |:.:.::|:.:|...|....||..|
 Frog   239 SILCF-FSSAFTVLTFLVDPLRFKYPE-----RPIIFLSMCYCVYSVGYIIRLFAGADSIACDRD 297

  Fly   302 PQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNF 366
               ..:..:..:||.:..|..|||:.||||||:..||.:|.|.|.....:    ..||..|.:|
 Frog   298 ---SGQLYVIQEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGK----KWGHEAIEAN- 354

  Fly   367 GGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQI 431
                               :::....||.:||.:|..::|.|.|..|||.|.|:||:....||..
 Frog   355 -------------------SSYFHLAAWAIPAVKTIMILVMRRVAGDELTGVCYVGSMDVNALTG 400

  Fly   432 LVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLAC 496
            .|..|:.||.|.|:..::||::.....:.:::.....:  .:|::|...    ||:|..:|.:..
 Frog   401 FVLIPLACYLIIGTSFILSGFVALFHIRRVMKTGGENT--DKLEKLMVR----IGVFSVLYTVPA 459

  Fly   497 AMLLLAVIYEFANIDVW--LGSGD-------------TNTPLWP----FLLRAFMELMLGICCFA 542
            ..::....||..|:|.|  |.:.|             |.|...|    |:::.||.|::||....
 Frog   460 TCVIACYFYERLNMDFWKILATQDKCKMDSQTKTLDCTMTSSIPAVEIFMVKIFMLLVVGITSGM 524

  Fly   543 WVLGPSISTLYKRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPL 607
            |:.                                          .:.||.|:.:|.:.......
 Frog   525 WIW------------------------------------------TSKTVQSWQNVFSKRLKKRN 547

  Fly   608 PPSPYKLKTSPGTGSISLNQMSNYSLGRSVHHQQRHSPHHHH 649
            ...|..:.||.|                 ::.:.:|.|..||
 Frog   548 RSKPASVITSAG-----------------IYKKPQHPPKIHH 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	59/141 (42%)
		7tmF_Frizzled_SMO	222..557	CDD:320089	87/356 (24%)
		TM helix 1	231..256	CDD:320089	6/24 (25%)
		TM helix 2	268..289	CDD:320089	4/23 (17%)
		TM helix 3	321..347	CDD:320089	14/25 (56%)
		TM helix 4	388..404	CDD:320089	5/15 (33%)
		TM helix 5	426..455	CDD:320089	10/28 (36%)
		TM helix 6	481..508	CDD:320089	6/26 (23%)
		TM helix 7	519..544	CDD:320089	9/28 (32%)
fzd10	NP_001005669.1	CRD_FZ10	35..161	CDD:143571	59/128 (46%)
		7tmF_FZD10	221..540	CDD:320165	91/399 (23%)
		TM helix 1	230..255	CDD:320165	6/25 (24%)
		TM helix 2	264..285	CDD:320165	4/25 (16%)
		TM helix 3	314..340	CDD:320165	14/25 (56%)
		TM helix 4	357..373	CDD:320165	5/15 (33%)
		TM helix 5	395..424	CDD:320165	10/28 (36%)
		TM helix 6	444..471	CDD:320165	7/30 (23%)
		TM helix 7	501..526	CDD:320165	7/24 (29%)