DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz4 and Fzd8

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001037716.1	Gene:	Fzd8 / 364754	RGDID:	1560525	Length:	684	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	178/734 - (24%)
Similarity:	282/734 - (38%)	Gaps:	192/734 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKPTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMP 65
            ::.|.:|..|.|:        ..:||..:||:...:         |:.|.:.:|:.||||.|.||
  Rat     7 LEVTSLLAALAVL--------QRSSGAAAASAKELA---------CQEITVPLCKGIGYNYTYMP 54

  Fly    66 NLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTP--KAPVHAIGPCRSLCESVRI 128
            |...::.|.:....:..|.||:|..||..||.|||:.|.|:|..  |.|   :.||||:||..:.
  Rat    55 NQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKP---LPPCRSVCERAKA 116

  Fly   129 RCHPVLQGFGFPWPPALDCDKFPRENNHETMCME------------GPGELHQPQQEQDLYGLPG 181
            .|.|:::.:||.||..:.||:.|.:.|.:|:||:            .|..|..||        ||
  Rat   117 GCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPQ--------PG 173

  Fly   182 QGIPGGLGGKLPM---------------DCSGLAKSHLYVRLPRSGRCAPL-----CEADILFTP 226
            :..|.|.|...|.               |.:....|......|..|..||.     |.|.::...
  Rat   174 EQPPSGSGHSRPPGARPPHRGGSSRGSGDTAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVS 238

  Fly   227 AEKH-----------------------------LAEIWVSTWAYAALGLALVATVCLLASDGSRL 262
            :|:|                             ....|:..|:.... ::..|||.....|..|.
  Rat   239 SERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCF-VSTFATVSTFLIDMERF 302

  Fly   263 ASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTAC------------------------GT 300
            ...:     .|:|:   |:..|::|:.||.:.|....||                        |.
  Rat   303 KYPE-----RPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAATAGAGAAGA 362

  Fly   301 DPQAPN-----------ESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSP 354
            ...:|.           |..:..:....|.|..|||:.|:||||:..||.:|.|.|
  Rat   363 GASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTW--------- 418

  Fly   355 DSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGAC 419
                       |..:..|..:...|    ..:.:....||.:|:.::.||:....||.|.:.|.|
  Rat   419 -----------FLAAGMKWGNEAIA----GYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGIC 468

  Fly   420 FVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSG 484
            :|||||...|:..|..|:..|...|:|.|::|::...|.:.:::.....:...:|::|...
  Rat   469 YVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIR---- 529

  Fly   485 IGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTP----LWP----------FLLRAFMELM 535
            :|:|..:|.:..|:::..:.||..|...|  ....|.|    |.|          |:|:.||.|:
  Rat   530 LGLFTVLYTVPAAVVVACLFYEQHNRPRW--EATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLV 592

  Fly   536 LGICCFAWV-LGPSIST---LYKR--QVSNGKMVKHTSAGA-------ATGHLDGHSSSRGSHAA 587
            :||....|| .|.::.:   |..|  ..|.|..|...:.|:       ..|...||....||..:
  Rat   593 VGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGGGPGPGGGGGHGGGGGSLYS 657

  Fly   588 CNSTVVSYHSVRTSMASVP 606
            ..||.:::.|...|..|.|
  Rat   658 DVSTGLTWRSGTASSVSYP 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	49/139 (35%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	85/401 (21%)
Fzd8	NP_001037716.1	CRD_FZ8	31..155	CDD:143570	47/135 (35%)
		Palmitate-binding groove. /evidence=ECO:0000250	71..78		3/6 (50%)
		Wnt-binding. /evidence=ECO:0000250	95..100		1/4 (25%)
		Wnt-binding. /evidence=ECO:0000250	147..152		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..222		14/74 (19%)
		PHA03356	<183..219	CDD:177594	4/35 (11%)
		Frizzled	264..614	CDD:279827	86/385 (22%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	605..610		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..655		5/24 (21%)
		PDZ-binding. /evidence=ECO:0000250	682..684
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820