Protein Alignment fz4 and szl

DIOPT Version :10

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_858049.1
• Gene: szl / 353294
• ZFINID: ZDB-GENE-030530-1
• Length: 282
• Species: Danio rerio
• Alignment Length: 275
• Identity: 64/275 - (23%)
• Similarity: 109/275 - (39%)
• Gaps: 75/275 - (27%)

  Fly    45 QCETI--RIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAP-------LIEYDCSSQLKLFLC 100
            :|..|  ::.:|:.:.|:|..:|||:|:.       :|:..||       |:...|..|.:.|:|
Zfish    26 RCVPIPPQMSVCQDVPYSEMRLPNLLGHG-------SLEEAAPRSDDLRTLLHTGCHPQARAFVC 83

  Fly   101 AAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENN-------H-- 156
            :...|:|..:    .|.||||:|.:|:..|.|||...|..||.:|:|::||.:::       |
Zfish    84 SLIAPVCLDR----FIQPCRSVCLAVKESCSPVLACHGHSWPESLNCERFPEQDDCLTPLPKHIS 144

  Fly   157 -------ETMCMEGPGELHQPQQEQDLYGL--------------------PGQGIPGGL-----G 189
                   :..|...|.....|..:..|..|                    |...:.|.:     |
Zfish   145 AFSKEFPQPACQSCPSVQESPSLKTLLDSLCLNDFAVKVKIMRRRVPSSEPEFTVEGAVELIERG 209

  Fly   190 GKLPMDCSGLAKSHLYVRLPRSGRCAPLCEADILFTPAEKHLAEIWVSTWAYAALGLALVATVCL 254
            ..:|.|.:.|.:..:.:.|    ||     |..|..|..   |::::.|....|.|...:|.:..
Zfish   210 PLMPYDTASLLQRWMLINL----RC-----AHALVRPGR---AQLYLITGKMRAGGSIEIANLFP 262

  Fly   255 LASDGSRLASA--KW 267
            .......:|:|  ||
Zfish   263 WLKKDLHIATATRKW 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	40/148 (27%)
		7tmF_Frizzled_SMO	222..557	CDD:320089	11/48 (23%)
		TM helix 1	231..256	CDD:320089	5/24 (21%)
		TM helix 2	268..289	CDD:320089	64/275 (23%)
		TM helix 3	321..347	CDD:320089
		TM helix 4	388..404	CDD:320089
		TM helix 5	426..455	CDD:320089
		TM helix 6	481..508	CDD:320089
		TM helix 7	519..544	CDD:320089
szl	NP_858049.1	CRD_FZ	19..158	CDD:470581	39/142 (27%)
		NTR_Sfrp1_like	152..282	CDD:239635	26/138 (19%)