DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and Fzd5

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_776210.1	Gene:	Fzd5 / 317674	RGDID:	631406	Length:	585	Species:	Rattus norvegicus

Alignment Length:	643	Identity:	169/643 - (26%)
Similarity:	273/643 - (42%)	Gaps:	113/643 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNL 67
            |..:|.||:..|:            ..|:::|.:|       .|:.|.:.|||.||||.|.|||.
  Rat     9 PPSLLLLLLAQLV------------GRAAAASKAP-------VCQEITVPMCRGIGYNLTHMPNQ 54

  Fly    68 VGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVH-AIGPCRSLCESVRIRCH 131
            ..::.|.:....:..|.||:|..||..|:.|||:.|.|:|.|  ..| .:.||||:||..:..|.
  Rat    55 FNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLP--DYHKPLPPCRSVCERAKAGCS 117

  Fly   132 PVLQGFGFPWPPALDCDKFP-RENNHETMCME---GPGELHQPQQ---EQDLYGLPGQGIPGG-- 187
            |:::.:||.||..:.||:.| ...:.|.:||:   .......|:.   :..|.|.||....||
  Rat   118 PLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGGEC 182

  Fly   188 -LGGKLPMDCSG-----LAKSH-LY--VRLPRSGRCAPLCEADILFTPAEKHLAEIWVSTWAYAA 243
             .||.....|..     |.:|| ||  ||..:...||..|... .|:|.|:..|..|:..|:...
  Rat   183 PSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQP-SFSPDERTFATFWIGLWSVLC 246

  Fly   244 LGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAP 305
            . ::...||.....|..|....:     .|:|:   |:..|:||:.||.:||....||..:
  Rat   247 F-ISTSTTVATFLIDMERFRYPE-----RPIIFLSACYLCVSLGFLVRLVVGHASVACSRE---- 301

  Fly   306 NESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSP 370
             .|.:..:....|.|..|||:.|:||||:..||.:|.|.|             .:.....:|...
  Rat   302 -HSHIHYETTGPALCTVVFLLVYFFGMASSIWWVILSLTW-------------FLAAGMKWGNEA 352

  Fly   371 AKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVAT 435
            .    |..||       :....||.:|:.::...:....||.|.:.|.|:||||:..:|:..|..
  Rat   353 I----AGYAQ-------YFHLAAWLIPSVKSITALALSSVDGDPVAGVCYVGNQNLNSLRGFVLG 406

  Fly   436 PVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLL 500
            |:..|.:.|::.|::|::...|.:.:::.....:  .:|::|...    ||||..:|.:..::::
  Rat   407 PLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKT--DKLEKLMIR----IGIFTLLYTVPASIVV 465

  Fly   501 LAVIYEFANIDVWLGS-------GDTNTP-----LWPFLLRAFMELMLGICCFAWVLGPSISTLY 553
            ...:||....:.|..:       .|...|     .|..:|:.||.|::||....|:........:
  Rat   466 ACYLYEQHYRESWEAALTCACPGSDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESW 530

  Fly   554 KRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSP 611
            :|..|      .....:..||..|.:...|.:|..::.:..    ||.      ||.|
  Rat   531 RRFTS------RCCCSSRRGHKSGGAMVAGDYAEASAALTG----RTG------PPGP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	47/130 (36%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	81/335 (24%)
Fzd5	NP_776210.1	CRD_FZ5	29..156	CDD:143569	48/135 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..182		7/25 (28%)
		Frizzled	227..533	CDD:279827	82/346 (24%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	525..530		0/4 (0%)
		PDZ-binding. /evidence=ECO:0000250	583..585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920