Protein Alignment fz4 and Fzd5

DIOPT Version :10

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_776210.2
• Gene: Fzd5 / 317674
• RGDID: 631406
• Length: 585
• Species: Rattus norvegicus
• Alignment Length: 643
• Identity: 169/643 - (26%)
• Similarity: 273/643 - (42%)
• Gaps: 113/643 - (17%)

  Fly     3 PTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNL 67
            |..:|.||:..|:            ..|:::|.:|       .|:.|.:.|||.||||.|.|||.
  Rat     9 PPSLLLLLLAQLV------------GRAAAASKAP-------VCQEITVPMCRGIGYNLTHMPNQ 54

  Fly    68 VGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVH-AIGPCRSLCESVRIRCH 131
            ..::.|.:....:..|.||:|..||..|:.|||:.|.|:|.|  ..| .:.||||:||..:..|.
  Rat    55 FNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLP--DYHKPLPPCRSVCERAKAGCS 117

  Fly   132 PVLQGFGFPWPPALDCDKFP-RENNHETMCME---GPGELHQPQQ---EQDLYGLPGQGIPGG-- 187
            |:::.:||.||..:.||:.| ...:.|.:||:   .......|:.   :..|.|.||....||
  Rat   118 PLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGGEC 182

  Fly   188 -LGGKLPMDCSG-----LAKSH-LY--VRLPRSGRCAPLCEADILFTPAEKHLAEIWVSTWAYAA 243
             .||.....|..     |.:|| ||  ||..:...||..|... .|:|.|:..|..|:..|:...
  Rat   183 PSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQP-SFSPDERTFATFWIGLWSVLC 246

  Fly   244 LGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAP 305
            . ::...||.....|..|....:     .|:|:   |:..|:||:.||.:||....||..:
  Rat   247 F-ISTSTTVATFLIDMERFRYPE-----RPIIFLSACYLCVSLGFLVRLVVGHASVACSRE---- 301

  Fly   306 NESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSP 370
             .|.:..:....|.|..|||:.|:||||:..||.:|.|.|             .:.....:|...
  Rat   302 -HSHIHYETTGPALCTVVFLLVYFFGMASSIWWVILSLTW-------------FLAAGMKWGNEA 352

  Fly   371 AKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVAT 435
            .    |..||       :....||.:|:.::...:....||.|.:.|.|:||||:..:|:..|..
  Rat   353 I----AGYAQ-------YFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLG 406

  Fly   436 PVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLL 500
            |:..|.:.|::.|::|::...|.:.:::.....:  .:|::|...    ||||..:|.:..::::
  Rat   407 PLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKT--DKLEKLMIR----IGIFTLLYTVPASIVV 465

  Fly   501 LAVIYEFANIDVWLGS-------GDTNTP-----LWPFLLRAFMELMLGICCFAWVLGPSISTLY 553
            ...:||....:.|..:       .|...|     .|..:|:.||.|::||....|:........:
  Rat   466 ACYLYEQHYRESWEAALTCACPGSDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESW 530

  Fly   554 KRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSP 611
            :|..|      .....:..||..|.:...|.:|..::.:..    ||.      ||.|
  Rat   531 RRFTS------RCCCSSRRGHKSGGAMVAGDYAEASAALTG----RTG------PPGP 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	47/130 (36%)
		7tmF_Frizzled_SMO	222..557	CDD:320089	83/349 (24%)
		TM helix 1	231..256	CDD:320089	5/24 (21%)
		TM helix 2	268..289	CDD:320089	7/23 (30%)
		TM helix 3	321..347	CDD:320089	13/25 (52%)
		TM helix 4	388..404	CDD:320089	3/15 (20%)
		TM helix 5	426..455	CDD:320089	7/28 (25%)
		TM helix 6	481..508	CDD:320089	7/26 (27%)
		TM helix 7	519..544	CDD:320089	8/29 (28%)
Fzd5	NP_776210.2	CRD_FZ5	29..156	CDD:143569	48/135 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	156..182		7/25 (28%)
		7tm_GPCRs	225..535	CDD:475119	83/351 (24%)
		TM helix 1	235..259	CDD:410628	5/24 (21%)
		TM helix 2	268..289	CDD:410628	7/25 (28%)
		TM helix 3	316..338	CDD:410628	11/21 (52%)
		TM helix 4	359..375	CDD:410628	3/15 (20%)
		TM helix 5	397..420	CDD:410628	5/22 (23%)
		TM helix 6	451..473	CDD:410628	6/21 (29%)
		TM helix 7	496..521	CDD:410628	7/24 (29%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	525..530		0/4 (0%)
		PDZ-binding. /evidence=ECO:0000250	583..585