Protein Alignment fz4 and Sfrp2

DIOPT Version :10

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_001094170.1
• Gene: Sfrp2 / 310552
• RGDID: 735163
• Length: 295
• Species: Rattus norvegicus
• Alignment Length: 237
• Identity: 69/237 - (29%)
• Similarity: 96/237 - (40%)
• Gaps: 63/237 - (26%)

  Fly     9 LLVVILLHPRISKSS---TSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGN 70
            ||:|:..|..:..:.   ..|.|..|...|:...|||       .:::|..|.|....:|||:|:
  Rat     9 LLLVLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPA-------NLQLCHGIEYQNMRLPNLLGH 66

  Fly    71 EMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQ 135
            |...:|......:.||:...|....|.|||:.:.|:|..... ..|.||.|||..|:.||.||:.
  Rat    67 ETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLD-ETIQPCHSLCVQVKDRCAPVMS 130

  Fly   136 GFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLYGLPGQGIPGGLGGKLPMDCSGLA 200
            .||||||..|:||:||::|                    ||                   |..||
  Rat   131 AFGFPWPDMLECDRFPQDN--------------------DL-------------------CIPLA 156

  Fly   201 KS-HLYVRLPRSGRCAPLCEA---------DILFTPAEKHLA 232
            .| ||   ||.:.....:|||         ||:.|..:...|
  Rat   157 SSDHL---LPPTEEAPKVCEACKTKNEDDNDIMETLCKNDFA 195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	41/125 (33%)
		7tmF_Frizzled_SMO	222..557	CDD:320089	3/11 (27%)
		TM helix 1	231..256	CDD:320089	1/2 (50%)
		TM helix 2	268..289	CDD:320089
		TM helix 3	321..347	CDD:320089
		TM helix 4	388..404	CDD:320089
		TM helix 5	426..455	CDD:320089
		TM helix 6	481..508	CDD:320089
		TM helix 7	519..544	CDD:320089
Sfrp2	NP_001094170.1	CRD_SFRP2	36..163	CDD:143555	53/176 (30%)
		NTR_Sfrp1_like	169..295	CDD:239635	7/27 (26%)