DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz4 and fzd2

DIOPT Version :10

Sequence 1:NP_511068.2 Gene:fz4 / 31659 FlyBaseID:FBgn0027342 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_571215.1 Gene:fzd2 / 30370 ZFINID:ZDB-GENE-990415-224 Length:550 Species:Danio rerio


Alignment Length:620 Identity:164/620 - (26%)
Similarity:254/620 - (40%) Gaps:127/620 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKPTCILCLLVVILLHPRISKSSTSGNP-----SASSSSSSPPEIPAFRQCETIRIEMCRKIGYN 60
            |:.:..:|:.:.:||            |     |......:...:|....|:.|.|.:|..|.||
Zfish     1 MQASGSVCVFLALLL------------PCCFVASGQHQGDNGIAVPDHGFCQPITIPLCTDIAYN 53

  Fly    61 ETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCES 125
            :|.||||||:..|.|....:..|.||::..||.:||.|||:.|.|:||  ....||.||||:||.
Zfish    54 QTIMPNLVGHYNQEDAGLEVHQFYPLVKVQCSPELKFFLCSMYAPVCT--VLEKAIPPCRSICER 116

  Fly   126 VRIRCHPVLQGFGFPWPPALDCDKFP-------RENNHETMCMEGPGELHQP---QQEQDLYGLP 180
            .:..|..::..|||.||.||.|:.||       ....:::|....|  :|.|   .....||..|
Zfish   117 AKQGCEVLMNKFGFQWPEALRCEHFPVLGDGHICVGQNDSMATVSP--VHMPIPGTPSVQLYSTP 179

  Fly   181 GQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGR--CAPLCE------ADILFTPAEKHLAEIWVS 237
            .:          |..|....|...|:.....|.  |...||      |.:.||..|...|.||:.
Zfish   180 DK----------PFRCPSTLKVPAYLSYKFLGEPDCGAPCESSRTHRAYMFFTDQEIEFARIWIL 234

  Fly   238 TWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACG 299
            .|:.......|. ||.....|..|....:     .|:|:   |:.||::.:...:.:|       
Zfish   235 IWSSLCCASTLF-TVTTYIVDMQRFKYPE-----RPIIFLSGCYTMVSIAYIAGYFLG------- 286

  Fly   300 TDPQAPNESLL------TVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSK- 357
             |....|||..      .|.|.....|..:|:|.|:|.||:..||.:|.|.|..     :...| 
Zfish   287 -DKVVCNESFFPDSYKTIVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFL-----AAGMKW 345

  Fly   358 GHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVG 422
            ||..|.:|                    :.:....||.:||.:|.:::....:|.|.|.|.||||
Zfish   346 GHEAIEAN--------------------SQYFHLAAWAVPAVKTISILAMGQIDGDVLSGVCFVG 390

  Fly   423 NQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGI 487
            ..:..||:..:..|:|.|...|:..|::|::...|.:.|:::....:  ::|::|...    ||:
Zfish   391 LNNSDALRGFILAPLFLYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT--EKLERLMVR----IGV 449

  Fly   488 FLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNT--------PLWP----------FLLRAFMEL 534
            |..:|.:...:::....||.|....|..|..:..        |:.|          |:::..|.|
Zfish   450 FSVLYTVPATIVIACFFYEQAFRQQWEKSWISMNCKSLAIPCPMQPAPHMTPDFTVFMIKYLMTL 514

  Fly   535 MLGICCFAWVLGPSISTLYKRQVSNGKMVKHTSAG 569
            ::||....|:.  |..||:..|..   .|:.||||
Zfish   515 IVGITSGFWIW--SGKTLHSWQKF---YVRLTSAG 544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz4NP_511068.2 CRD_FZ4 43..169 CDD:143557 51/132 (39%)
7tmF_Frizzled_SMO 222..557 CDD:320089 86/362 (24%)
TM helix 1 231..256 CDD:320089 7/24 (29%)
TM helix 2 268..289 CDD:320089 5/23 (22%)
TM helix 3 321..347 CDD:320089 11/25 (44%)
TM helix 4 388..404 CDD:320089 5/15 (33%)
TM helix 5 426..455 CDD:320089 8/28 (29%)
TM helix 6 481..508 CDD:320089 6/26 (23%)
TM helix 7 519..544 CDD:320089 7/42 (17%)
fzd2NP_571215.1 CRD_FZ1_like 37..154 CDD:143567 49/118 (42%)
7tmF_FZD2 219..548 CDD:320373 92/376 (24%)
TM helix 1 228..253 CDD:320373 7/25 (28%)
TM helix 2 262..283 CDD:320373 5/25 (20%)
TM helix 3 313..339 CDD:320373 11/25 (44%)
TM helix 4 356..372 CDD:320373 5/15 (33%)
TM helix 5 394..423 CDD:320373 8/28 (29%)
TM helix 6 443..470 CDD:320373 7/30 (23%)
TM helix 7 499..524 CDD:320373 5/24 (21%)

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