Protein Alignment fz4 and fzd10

DIOPT Version :10

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_570992.2
• Gene: fzd10 / 30366
• ZFINID: ZDB-GENE-990415-220
• Length: 580
• Species: Danio rerio
• Alignment Length: 604
• Identity: 180/604 - (29%)
• Similarity: 280/604 - (46%)
• Gaps: 90/604 - (14%)

  Fly    31 SSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQL 95
            |:.||..|:.|...:|:.|.|.:|:.||||.|.||||:|:|.|.:....|..||||||:.|.|.|
Zfish    20 SAISSIDPDRPGEGRCQEIAIPLCKDIGYNLTVMPNLMGHEDQNEAAIKLHEFAPLIEFGCHSHL 84

  Fly    96 KLFLCAAYVPMCTPK--APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHET 158
            |.|||:.|.||||.:  .|:.|   ||.:||..|.:|.|:::.|.|.||.:|||.:.|.:|:...
Zfish    85 KFFLCSLYAPMCTEQVSTPIPA---CRVMCEQARQKCSPIMEQFNFHWPESLDCSRLPNKNDPNY 146

  Fly   159 MCMEGPGE-LHQPQQEQDLYGLPGQGIPGGLGGKLPM-------DCSGLAKSHLYVRLPRSGRCA 215
            :|||.|.. ..:|.:.........:....|...:||:       .||...|.| ||:  :|..||
Zfish   147 LCMEAPNNGTDEPPKGSHTQSPDSRPPRPGNSQELPIKERVGKTTCSNPGKFH-YVQ--KSESCA 208

  Fly   216 PLC--EADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIWCH 278
            |.|  ..|:.::..:|..:.:|::.|:.... ::...||.....|..|....:...:...:.:|
Zfish   209 PKCYSNVDVYWSQGDKRFSMVWIAIWSILCF-ISSAFTVLTFLIDPQRFKYPERPIIFLSMSYC- 271

  Fly   279 NMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCL 343
             :.::|:.||..||....||..|   .....:..:||.:..|..|||:.||||||:..||.:|.|
Zfish   272 -VYSVGFLVRLFVGVENVACDRD---TGVQYIIQEGLESTGCTIVFLILYYFGMASSLWWVILTL 332

  Fly   344 GWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVAR 408
            .|.....:    ..||..|.:|                    :::....||.:||.:|..::|.|
Zfish   333 TWFLAAGK----KWGHEAIEAN--------------------SSYFHLAAWAIPAIKTIMILVMR 373

  Fly   409 FVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQ 473
            .|..|||.|.|:||:...|||...|..|:.||.|.|:..|:||::.....:::::.....:  .:
Zfish   374 KVAGDELTGVCYVGSMDVKALTGFVLIPLSCYLIIGTSFLLSGFVALFHIRKVMKTEGENT--DK 436

  Fly   474 LQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWL------------GSGD-----TNT 521
            |::|...    ||:|..:|.:....::....||..|:|.|.            .||:     ::.
Zfish   437 LEKLMVR----IGVFSVLYTVPATCVIACYFYERLNMDYWKILAGEQKCADDGKSGEECVMKSSI 497

  Fly   522 P-LWPFLLRAFMELMLGICCFAWVLGPSISTLYKRQ-VSNGKMVKHTSAGAA---TGH------- 574
            | :..|:::.||.|::||....|:.  :..||...| |.:.|:.|.|...||   ||.
Zfish   498 PAVEIFMVKIFMLLVVGITSGMWIW--TSKTLQSWQNVFSRKLKKKTRRKAACVFTGSGPYLKPH 560

  Fly   575 --LDGHSSS---RGSHAAC 588
              |.||.:.   .|..|.|
Zfish   561 PALKGHKTKYEPAGPPATC 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	57/128 (45%)
		7tmF_Frizzled_SMO	222..557	CDD:320089	88/353 (25%)
		TM helix 1	231..256	CDD:320089	4/24 (17%)
		TM helix 2	268..289	CDD:320089	3/20 (15%)
		TM helix 3	321..347	CDD:320089	14/25 (56%)
		TM helix 4	388..404	CDD:320089	5/15 (33%)
		TM helix 5	426..455	CDD:320089	12/28 (43%)
		TM helix 6	481..508	CDD:320089	6/26 (23%)
		TM helix 7	519..544	CDD:320089	7/25 (28%)
fzd10	NP_570992.2	CRD_FZ	31..157	CDD:470581	57/128 (45%)
		7tmF_FZD10	217..535	CDD:320165	89/355 (25%)
		TM helix 1	226..251	CDD:320165	4/25 (16%)
		TM helix 2	260..281	CDD:320165	3/22 (14%)
		TM helix 3	310..336	CDD:320165	14/25 (56%)
		TM helix 4	353..369	CDD:320165	5/15 (33%)
		TM helix 5	391..420	CDD:320165	12/28 (43%)
		TM helix 6	440..467	CDD:320165	7/30 (23%)
		TM helix 7	496..521	CDD:320165	7/24 (29%)