DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz4 and fzd4

DIOPT Version :10

Sequence 1:NP_511068.2 Gene:fz4 / 31659 FlyBaseID:FBgn0027342 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_001292398.1 Gene:fzd4 / 30363 ZFINID:ZDB-GENE-990415-217 Length:523 Species:Danio rerio


Alignment Length:555 Identity:189/555 - (34%)
Similarity:269/555 - (48%) Gaps:103/555 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 CETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPK 110
            |:.|||.||:.:|||.|.|||||||.:|:|.|..|.||.|||:|.||||||.|||:.||||||.|
Zfish    29 CDPIRISMCQDLGYNVTKMPNLVGNVLQSDAELQLTTFTPLIQYGCSSQLKFFLCSVYVPMCTEK 93

  Fly   111 APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQP----- 170
            .|: .||||.|:|.||:.:|.||||.|||.||..|:|..||..|:...|||||||:...|     
Zfish    94 VPI-PIGPCGSMCMSVKRKCLPVLQEFGFVWPELLNCSLFPPTNDQNHMCMEGPGDEDPPFHAVR 157

  Fly   171 ---QQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLCEADI-LFTPAEKHL 231
               .||::...| |.|:                  ..|..:.|||.|:..|..|. |:....|..
Zfish   158 PVAPQEEECIAL-GAGV------------------EQYAWVKRSGSCSLQCGYDTGLYRRQAKVF 203

  Fly   232 AEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGR 293
            .::|::.||.... ::...||.....|.||.:..:     .|:|:   |.|:.::.:.||..|||
Zfish   204 TDVWMAVWAVLCF-ISTTFTVLTFLVDSSRFSYPE-----RPIIFLSMCCNIYSVAFIVRLTVGR 262

  Fly   294 TGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGW---------HRDI 349
            ...:|..:..|  ..:|..:||.|..||.|||:.|:||||:..||.:|.|.|         |..|
Zfish   263 ERISCDLEEAA--VPVLVQEGLKNTGCAIVFLLTYFFGMASSIWWVILTLTWFLAAGLKWGHEAI 325

  Fly   350 RRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADE 414
            ..||  |..|:                               .||.:||.:|..:::.|.||||:
Zfish   326 EMHS--SYFHI-------------------------------AAWAIPAVKTIVILIMRLVDADD 357

  Fly   415 LLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSA 479
            |.|.|:||||:..||...|..|:|.|.:.|::.:.:|.:...:.:..|:.....:  .:|::|..
Zfish   358 LAGMCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKT--DKLERLMV 420

  Fly   480 HSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDT--NTPLWPFLLRAFMELMLGICCFA 542
            .    ||:|..:|.:....::....||.:|   |.....|  ::.:...:||.||.|::||....
Zfish   421 K----IGVFSVLYTVPATCVIACYFYEISN---WADFRQTARDSYMAAEMLRIFMSLLVGITSGM 478

  Fly   543 WVLGPSISTLY------KRQVSNGK--MVKHTSAG 569
            ||.  |..||:      .|.|..|:  .||.|:.|
Zfish   479 WVW--SAKTLHTWQRCSHRLVHTGRNNRVKRTANG 511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz4NP_511068.2 CRD_FZ4 43..169 CDD:143557 74/122 (61%)
7tmF_Frizzled_SMO 222..557 CDD:320089 96/355 (27%)
TM helix 1 231..256 CDD:320089 5/24 (21%)
TM helix 2 268..289 CDD:320089 5/23 (22%)
TM helix 3 321..347 CDD:320089 14/34 (41%)
TM helix 4 388..404 CDD:320089 5/15 (33%)
TM helix 5 426..455 CDD:320089 8/28 (29%)
TM helix 6 481..508 CDD:320089 6/26 (23%)
TM helix 7 519..544 CDD:320089 8/26 (31%)
fzd4NP_001292398.1 TM helix 7 455..480 CDD:320166 7/24 (29%)
CRD_FZ4 26..150 CDD:143557 74/121 (61%)
7tmF_FZD4 194..493 CDD:320166 95/350 (27%)
TM helix 1 203..228 CDD:320166 5/25 (20%)
TM helix 2 237..258 CDD:320166 5/25 (20%)
TM helix 3 288..314 CDD:320166 14/25 (56%)
TM helix 4 331..347 CDD:320166 6/46 (13%)
TM helix 5 369..398 CDD:320166 8/28 (29%)
TM helix 6 418..445 CDD:320166 7/30 (23%)

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