DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz4 and Corin

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_872279.2	Gene:	Corin / 289596	RGDID:	727887	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	195	Identity:	55/195 - (28%)
Similarity:	80/195 - (41%)	Gaps:	35/195 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQT--FA 84
            ||...:.:.||...|...:.....||.|.:|:|..:.||.|..||.:|:..|.:...:.::  |.
  Rat   497 SSCVESCAGSSLCDSDSSLSNCSHCEPITLELCMNLPYNLTHYPNYLGHRTQKEASISWESALFP 561

  Fly    85 PLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDK 149
            .|::.:|...|..|.|...||.|..... ..:.|||.|||..:.||..||...|..||...||.:
  Rat   562 ALVQTNCYKYLMFFACTILVPKCDVNTG-QRVPPCRLLCEHSKERCESVLGIVGLQWPEDTDCSQ 625

  Fly   150 FPRENNHETMCMEGPGELHQPQQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRC 214
            ||.:::....|:                 ||.:.:.         :||   .||...   |||||
  Rat   626 FPEQSSDNQTCL-----------------LPNEDVE---------ECS---PSHFKC---RSGRC 658

Fly 215 214
Rat 659 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	39/127 (31%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433
Corin	NP_872279.2	DDNN motif	93..96
		CRD_corin_1	200..329	CDD:143554
		LDLa	335..370	CDD:238060
		LDLa	372..406	CDD:238060
		Ldl_recept_a	413..443	CDD:395011
		LDLa	453..480	CDD:238060
		CRD_corin_2	521..641	CDD:143579	41/137 (30%)
		Ldl_recept_a	646..680	CDD:395011	9/19 (47%)
		LDLa	<693..718	CDD:238060
		LDLa	721..755	CDD:238060
		SRCR_2	779..859	CDD:413346
		Tryp_SPc	867..1098	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810