DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and Fzd6

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001124008.1	Gene:	Fzd6 / 282581	RGDID:	628816	Length:	710	Species:	Rattus norvegicus

Alignment Length:	657	Identity:	160/657 - (24%)
Similarity:	263/657 - (40%)	Gaps:	144/657 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPK 110
            ||.|.:..|.|:.||.|..|||:|:..|......::.|.||...:||..:::|||.|:||.||.:
  Rat    24 CEPITVPRCMKMAYNMTFFPNLMGHYDQGIAAVEMEHFLPLANLECSPNIEMFLCQAFVPTCTEQ 88

  Fly   111 APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQD 175
              :..:.|||.|||.:...|..::..||..||..|:|.:.|..:....:..:...||..||::.|
  Rat    89 --IDVVSPCRKLCEKILSDCQKLMDTFGIRWPEELECHRLPYCDGAVPVTSDPHTELFGPQKKTD 151

  Fly   176 LYGLPGQGIPGGLGGKLPMDCSGLAKSHLYV------RLPRSGRCAPLCEADILFTPAEKHLAEI 234
                           ::|.|.......||..      |.....:|||.| .::.|...|...|:.
  Rat   152 ---------------QVPRDIGFWCPKHLRTSGDQGYRFLGIDQCAPPC-PNMYFKSDELDFAKS 200

  Fly   235 WVSTWAYAALGLALVATVCLLAS---------DGSRLASAKWSRLLSPLIW---CHNMVTLGWAV 287
            ::          .:|:..||.|:         |..|....:     .|:|:   |:::|:|.:.|
  Rat   201 FI----------GIVSIFCLCATLFTFLTFLIDVRRFRYPE-----RPIIYYSVCYSIVSLMYFV 250

  Fly   288 RFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRH 352
            .|::|.: |||....:........|.|..|.:|:.||:..|:|.||...||.:|.:.|..
  Rat   251 GFLLGNS-TACNKADEKLELGNTVVLGSKNKACSVVFMFLYFFTMAGTVWWVILTITWFL----- 309

  Fly   353 SPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCF--VAWGLPAFQTSAVIVARFVDADEL 415
                            :..::.|.:..:|     ..|.|  ||||:|.|.|..::....|:.|.:
  Rat   310 ----------------AAGRKWSCEAIEQ-----KAVWFHAVAWGMPGFLTVMLLAMNKVEGDNI 353

  Fly   416 LGACFVGNQSDKALQILVATPVFCYWIF-GSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSA 479
            .|.||||.....|.:..|..|: |..:| |...|::|.:.....::::::..  ..|::|::...
  Rat   354 SGVCFVGLYDLDASRYFVLLPL-CLCVFVGLSLLLAGIISLNHVRQVIQHDG--RNQEKLKKFMI 415

  Fly   480 HSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVW------------------LGSGDTNTPLWPF 526
            .    ||:|..:|.:....||...:||..|...|                  ..:......|..|
  Rat   416 R----IGVFSGLYLVPLVTLLGCYVYELVNRVTWEMTWFSDHCHQYRIPCPYQANPKARPELALF 476

  Fly   527 LLRAFMELMLGICCFAWVLGPSISTLY--------KRQ-VSNGKMV---------KHTSAGAATG 573
            :::..|.|::||....||......|.:        ||. :|..:.|         ||.|   ...
  Rat   477 MIKYLMTLIVGISAVFWVGSKKTCTEWAGFCKRNRKRDPISESRRVLQESCEFFLKHNS---KVR 538

  Fly   574 HLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSPYKLKTSPGTGSISLNQMSNYSLGRSVH 638
            |...|... |||   ...|:| .|:.||..          :.|..||.::::.. .:| ||:...
  Rat   539 HKKKHGKP-GSH---KLKVIS-KSMGTSTG----------VTTDHGTSAVAIAD-HDY-LGQETS 586

  Fly   639 HQQRHSP 645
            .:.:.||
  Rat   587 AEVQTSP 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	42/122 (34%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	78/353 (22%)
Fzd6	NP_001124008.1	CRD_FZ6	20..146	CDD:143559	42/123 (34%)
		7tmF_FZD6	188..508	CDD:320160	81/368 (22%)
		TM helix 1	198..222	CDD:320160	5/33 (15%)
		TM helix 2	231..252	CDD:320160	6/25 (24%)
		TM helix 3	283..305	CDD:320160	9/21 (43%)
		TM helix 4	326..342	CDD:320160	8/15 (53%)
		TM helix 5	364..387	CDD:320160	6/23 (26%)
		TM helix 6	418..440	CDD:320160	7/21 (33%)
		TM helix 7	469..494	CDD:320160	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810