DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz4 and Fzd9

DIOPT Version :9

Sequence 1:NP_511068.2 Gene:fz4 / 31659 FlyBaseID:FBgn0027342 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_695217.1 Gene:Fzd9 / 266608 RGDID:628817 Length:592 Species:Rattus norvegicus


Alignment Length:618 Identity:177/618 - (28%)
Similarity:269/618 - (43%) Gaps:138/618 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 CETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPK 110
            |:.:.|.|||.||||.|.||||:|:..|.:....|..|:||::|.|.|.|:.|||:.|.||||.:
  Rat    40 CQAMEIPMCRGIGYNLTRMPNLLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLCSLYAPMCTDQ 104

  Fly   111 --APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCME-------GPGE 166
              .|:.|   ||.:||..|:||.|:::.|.|.||.:|||.:.|..|:...:|||       ||.|
  Rat   105 VSTPIPA---CRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPTE 166

  Fly   167 LHQPQQEQDLYGL------------PGQGIPG-GLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLC 218
            .|:        ||            ||...|| |.||    .|....|.. ||...||  |||.|
  Rat   167 PHK--------GLGMLPVAPRPARPPGDSAPGPGSGG----TCDNPEKFQ-YVEKSRS--CAPRC 216

  Fly   219 --EADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSP-------- 273
              ..::.::..:|..|.:|::.|          :.:|..::     |...::.||.|        
  Rat   217 GPGVEVFWSRRDKDFALVWMAVW----------SALCFFST-----AFTVFTFLLEPHRFQYPER 266

  Fly   274 ----LIWCHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTV-DGLSNASCASVFLMRYYFGMA 333
                |..|:|:.:|.:.:|.:.|....||..:..|    |..: :||.|..|..|||:.||||||
  Rat   267 PIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGA----LYVIQEGLENTGCTLVFLLLYYFGMA 327

  Fly   334 ACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPA 398
            :..||.||.|.|.....:    ..||..|.::                    .::....||||||
  Rat   328 SSLWWVVLTLTWFLAAGK----KWGHEAIEAH--------------------GSYFHMAAWGLPA 368

  Fly   399 FQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILR 463
            .:|..|:..|.|..|||.|.|:|.:....||...|..|:.||.:.|:..|::|::.....::|::
  Rat   369 LKTIVVLTLRKVAGDELTGLCYVASMDPAALTGFVLVPLSCYLVLGTSFLLTGFVALFHIRKIMK 433

  Fly   464 NSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWL-------------- 514
            .....:  ::|::|...    ||:|..:|.:....:::..:||..|:|.|.              
  Rat   434 TGGTNT--EKLEKLMVK----IGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCTAAAVP 492

  Fly   515 -GSGDTNTP------LWPFLLRAFMELMLGICCFAWVLGPSI-----STLYKRQVSNGKMVKHTS 567
             |..|.:.|      :..|:|:.||.|::||....||.....     |..|::..:.....|...
  Rat   493 GGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKMAAGRARAKACR 557

  Fly   568 AGAATGHLDGHSSSRGSHAACNSTVVSYHSVRT 600
            .....|        ||:|....:..|..|..:|
  Rat   558 TPGGYG--------RGTHCHYKAPTVVLHMTKT 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz4NP_511068.2 CRD_FZ4 43..169 CDD:143557 57/131 (44%)
7tm_4 223..544 CDD:304433 88/354 (25%)
Fzd9NP_695217.1 CRD_FZ9 36..162 CDD:143572 54/124 (44%)
Required for Wnt-activated receptor activity. /evidence=ECO:0000269|PubMed:12138115 59..173 49/124 (40%)
7tmF_FZD9 222..543 CDD:320164 91/369 (25%)
TM helix 1 232..256 CDD:320164 5/38 (13%)
TM helix 2 265..286 CDD:320164 4/20 (20%)
TM helix 3 315..337 CDD:320164 13/21 (62%)
TM helix 4 358..374 CDD:320164 7/15 (47%)
TM helix 5 396..419 CDD:320164 7/22 (32%)
TM helix 6 450..472 CDD:320164 5/21 (24%)
TM helix 7 504..529 CDD:320164 7/24 (29%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 533..538 0/4 (0%)
Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000269|PubMed:12138115 555..592 7/36 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D237456at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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