| Sequence 1: | NP_511068.2 | Gene: | fz4 / 31659 | FlyBaseID: | FBgn0027342 | Length: | 705 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001457.1 | Gene: | FZD2 / 2535 | HGNCID: | 4040 | Length: | 565 | Species: | Homo sapiens |
| Alignment Length: | 598 | Identity: | 165/598 - (27%) |
|---|---|---|---|
| Similarity: | 255/598 - (42%) | Gaps: | 113/598 - (18%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1 MKPTCIL-CLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSM 64
Fly 65 PNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIR 129
Fly 130 CHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLY------GL-PGQ-GIPG 186
Fly 187 GLGG----------KLPMDCSGLAK--SHLYVRLPRSGRCAPLCE-----ADILFTPAEKHLAEI 234
Fly 235 WVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGT 296
Fly 297 ACGTDPQAPNESL------LTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPD 355
Fly 356 SK-GHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGAC 419
Fly 420 FVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSG 484
Fly 485 IGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTN-------------TP-LWP----FLLRAF 531
Fly 532 MELMLGICCFAWV 544 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| fz4 | NP_511068.2 | CRD_FZ4 | 43..169 | CDD:143557 | 51/125 (41%) |
| 7tm_4 | 223..544 | CDD:304433 | 80/348 (23%) | ||
| FZD2 | NP_001457.1 | CRD_FZ2 | 35..161 | CDD:143573 | 52/131 (40%) |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 160..189 | 11/28 (39%) | |||
| 7tmF_FZD2 | 234..563 | CDD:320373 | 81/351 (23%) | ||
| TM helix 1 | 244..268 | CDD:320373 | 6/24 (25%) | ||
| TM helix 2 | 277..298 | CDD:320373 | 5/25 (20%) | ||
| TM helix 3 | 328..350 | CDD:320373 | 9/21 (43%) | ||
| TM helix 4 | 371..387 | CDD:320373 | 5/15 (33%) | ||
| TM helix 5 | 409..432 | CDD:320373 | 6/22 (27%) | ||
| TM helix 6 | 463..485 | CDD:320373 | 5/21 (24%) | ||
| TM helix 7 | 514..539 | CDD:320373 | 5/24 (21%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 543..548 | ||||
| PDZ-binding | 563..565 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.810 | |||||