DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz4 and FZD2

DIOPT Version :10

Sequence 1:NP_511068.2 Gene:fz4 / 31659 FlyBaseID:FBgn0027342 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_001457.1 Gene:FZD2 / 2535 HGNCID:4040 Length:565 Species:Homo sapiens


Alignment Length:598 Identity:165/598 - (27%)
Similarity:255/598 - (42%) Gaps:113/598 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKPTCIL-CLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSM 64
            |:|...| .||:.:||.|....:...|....|        ||....|:.|.|.:|..|.||:|.|
Human     1 MRPRSALPRLLLPLLLLPAAGPAQFHGEKGIS--------IPDHGFCQPISIPLCTDIAYNQTIM 57

  Fly    65 PNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIR 129
            |||:|:..|.|....:..|.||::..||.:|:.|||:.|.|:||  ....||.||||:||..|..
Human    58 PNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCT--VLEQAIPPCRSICERARQG 120

  Fly   130 CHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLY------GL-PGQ-GIPG 186
            |..::..|||.||..|.|:.||| :..|.:|:   |:.|.......|.      || ||. |.||
Human   121 CEALMNKFGFQWPERLRCEHFPR-HGAEQICV---GQNHSEDGAPALLTTAPPPGLQPGAGGTPG 181

  Fly   187 GLGG----------KLPMDCSGLAK--SHLYVRLPRSGRCAPLCE-----ADILFTPAEKHLAEI 234
            |.||          :.|..|..:.|  |:|..:......||..||     ..:.|:..|...|.:
Human   182 GPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARL 246

  Fly   235 WVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGT 296
            |:.||:..... :...||.....|..|....:     .|:|:   |:.||::.:...|:: :...
Human   247 WILTWSVLCCA-STFFTVTTYLVDMQRFRYPE-----RPIIFLSGCYTMVSVAYIAGFVL-QERV 304

  Fly   297 ACGTDPQAPNESL------LTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPD 355
            .|       ||..      ..|.|.....|..:|:|.|:|.||:..||.:|.|.|..     :..
Human   305 VC-------NERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFL-----AAG 357

  Fly   356 SK-GHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGAC 419
            .| ||..|.:|                    :.:....||.:||.:|..::....:|.|.|.|.|
Human   358 MKWGHEAIEAN--------------------SQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVC 402

  Fly   420 FVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSG 484
            |||..|...|:..|..|:|.|...|:..|::|::...|.:.|:::....:  ::|::|...    
Human   403 FVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT--EKLERLMVR---- 461

  Fly   485 IGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTN-------------TP-LWP----FLLRAF 531
            ||:|..:|.:...:::....||.|..:.|..|..:.             || :.|    ::::..
Human   462 IGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYL 526

  Fly   532 MELMLGICCFAWV 544
            |.|::||....|:
Human   527 MTLIVGITSGFWI 539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz4NP_511068.2 CRD_FZ4 43..169 CDD:143557 51/125 (41%)
7tmF_Frizzled_SMO 222..557 CDD:320089 81/351 (23%)
TM helix 1 231..256 CDD:320089 6/24 (25%)
TM helix 2 268..289 CDD:320089 5/23 (22%)
TM helix 3 321..347 CDD:320089 11/25 (44%)
TM helix 4 388..404 CDD:320089 5/15 (33%)
TM helix 5 426..455 CDD:320089 8/28 (29%)
TM helix 6 481..508 CDD:320089 6/26 (23%)
TM helix 7 519..544 CDD:320089 7/42 (17%)
FZD2NP_001457.1 CRD_FZ2 35..161 CDD:143573 52/131 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..189 11/28 (39%)
7tmF_FZD2 234..563 CDD:320373 81/351 (23%)
TM helix 1 243..268 CDD:320373 6/25 (24%)
TM helix 2 277..298 CDD:320373 5/25 (20%)
TM helix 3 328..354 CDD:320373 11/25 (44%)
TM helix 4 371..387 CDD:320373 5/15 (33%)
TM helix 5 409..438 CDD:320373 8/28 (29%)
TM helix 6 458..485 CDD:320373 7/30 (23%)
TM helix 7 514..539 CDD:320373 5/24 (21%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 543..548
PDZ-binding 563..565
Blue background indicates that the domain is not in the aligned region.

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