DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and mom-5

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001300437.1	Gene:	mom-5 / 172856	WormBaseID:	WBGene00003397	Length:	570	Species:	Caenorhabditis elegans

Alignment Length:	617	Identity:	165/617 - (26%)
Similarity:	254/617 - (41%)	Gaps:	143/617 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGN 70
            ||.|...:....|:|.:|.|.....|::          |:||.|.|.||:.:.||:|..|||:|:
Worm     7 ILFLFGCLSADQRLSSTSISSMNGFSTT----------RKCEHITIPMCKNLDYNQTVFPNLLGH 61

  Fly    71 EMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTP-KAPVHAIGPCRSLCESVRIRCHPVL 134
            ..|::....:..|.|||:..||..::||||..|.|:||. :.|:.   |||.||.|.:..|..::
Worm    62 TTQSEAGPAIAQFNPLIKVKCSEDIRLFLCTVYAPVCTVLEKPIQ---PCRELCLSAKNGCESLM 123

  Fly   135 QGFGFPWPPALDCDKFP-------------------RENNHETM---------------CMEGPG 165
            :.|||.||..|||:|||                   |.:|..|.               |   |.
Worm   124 KKFGFQWPDQLDCNKFPVTDLCVGKNSSESSNSKNYRSSNDVTFGVSTIANEVVLSPKKC---PH 185

  Fly   166 ELHQPQQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLCEAD----ILFTP 226
            .:|......  :.||      .|.|:||                   .|:..||||    ::|..
Worm   186 HMHTTSGSH--FSLP------LLSGRLP-------------------ECSLTCEADNQVPMMFDG 223

  Fly   227 AEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIWCHNMVTLGWAVRFMV 291
            ..:.:..||.:.|:.|....:|...|..|. |.||.|..  .|.:..|.:|:..::..:.:. :|
Worm   224 RVRRILRIWTAAWSVACFVCSLFTLVTFLV-DLSRFAYP--VRPILYLAFCYLAISTVYMIG-VV 284

  Fly   292 GRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDS 356
            |..|.||||....|  :.|...|..|..|:::.::.|:|.|::||||.||||.|.
Worm   285 GEDGFACGTYGSTP--TTLVTQGGENVGCSALAVVHYFFFMSSCAWWLVLCLAWF---------- 337

  Fly   357 KGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFV 421
                          ...|....|:.....:.:...:.||:||..:..|:|...||.|...|.|.|
Worm   338 --------------LAANLKWGAESIAALSPYFHAMCWGVPAVLSVTVLVTNSVDGDVFTGICSV 388

  Fly   422 GNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIG 486
            ||.:..||.....||:......|::.|:.|.....|.:..::..:| .|::.:.:|. .....||
Worm   389 GNLNPSALVYFFFTPIVVSLALGAVLLVCGIWSMIRIRSYIKLQHA-DVERNISKLE-KLMLRIG 451

  Fly   487 IFLFIYGLACAMLLLAVIYEFANIDVWLGS---------------GDT----NTPLWP------- 525
            .|..:|.|..||....:.|:..|:..||..               |.|    :.|:.|
Worm   452 AFAIMYSLPTAMNAAIMWYQAVNMPAWLEGWLHHRCVRLQDRELFGFTYPVDDCPMDPKVAAPEI 516

  Fly   526 --FLLRAFMELMLGICCFAWVL-GPSISTLYK 554
              |||:...:|::||.|..||: ..::|:.:|
Worm   517 IVFLLKYVSQLVVGITCAIWVVSSKTLSSYHK 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	53/160 (33%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	88/348 (25%)
mom-5	NP_001300437.1	CRD_FZ1_like	35..147	CDD:143567	48/114 (42%)
		7tmF_Frizzled_SMO	219..550	CDD:320089	92/362 (25%)
		TM helix 1	228..253	CDD:320089	6/24 (25%)
		TM helix 2	262..282	CDD:320089	3/19 (16%)
		TM helix 3	312..338	CDD:320089	12/49 (24%)
		TM helix 4	355..371	CDD:320089	4/15 (27%)
		TM helix 5	393..422	CDD:320089	7/28 (25%)
		TM helix 6	446..473	CDD:320089	8/26 (31%)
		TM helix 7	512..537	CDD:320089	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810