Protein Alignment fz4 and lin-17

DIOPT Version :9

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: NP_001021813.1
• Gene: lin-17 / 171832
• WormBaseID: WBGene00003006
• Length: 558
• Species: Caenorhabditis elegans
• Alignment Length: 617
• Identity: 151/617 - (24%)
• Similarity: 238/617 - (38%)
• Gaps: 138/617 - (22%)

  Fly    45 QCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQT----FAPLIEYDCSSQLKLFLCAAYVP 105
            :|..|.||:|:.:.||.|..||.:   :..| ::||||    |.||::..|...:..|:|:.:.|
 Worm    27 KCIPIDIELCKDLPYNYTYFPNTI---LHND-QHTLQTHTEHFKPLMKTKCHPHIHFFICSVFAP 87

  Fly   106 MCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQP 170
            || |.....|:..|:|:||.|:..|..:|:.||..||..|:|.:||           .|.||...
 Worm    88 MC-PIGMPQAVTSCKSVCEQVKADCFSILEEFGIGWPEPLNCAQFP-----------DPPELCMK 140

  Fly   171 QQEQDLYG------LPGQGI------PGGLGGKL----PMDCSGLAKSHLYVRLPRSGRCAPLCE 219
            ..|.::.|      ||.:|.      |.|....|    |.|    .|||          ||..|:
 Worm   141 PTEDEITGGFSAPRLPTKGSSSSSSKPTGCPSDLVDVDPHD----PKSH----------CAFACQ 191

  Fly   220 ADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIWCHNMVTLG 284
            ::::|:...|.:...|...:|.|..|:||.:.: ..|.|..|....:  |.:..|..|..:.:|.
 Worm   192 SNVMFSTDNKRMVRSWSIWFAAANAGVALFSFL-TFAIDRKRFRFPE--RCVFYLSLCIFISSLP 253

  Fly   285 WAVRFMVG---RTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWH 346
            :.....:.   |:..|.|.     ..|.|::....|:.|.:.||:.|:|..||..||.:.....:
 Worm   254 YLTPLFIDAPIRSCHALGN-----GRSYLSIGTFDNSYCLASFLLNYFFSTAAALWWLMFSFTLY 313

  Fly   347 RDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVD 411
            .        |.|...:|......                :::|.||||||.:..|..|::...||
 Worm   314 L--------SGGRKWVPEGIEAC----------------SSYVHFVAWGLSSLATIIVLIFNKVD 354

  Fly   412 ADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQ 476
            |.||...|.|||.:..||...|..|.....:.|:..::.|:...||.:...|...  :...:|::
 Worm   355 ASELTALCSVGNLNSIALLWFVIVPRTICIVIGTCFIVGGFASMCRERISFRTRG--TDTSKLEK 417

  Fly   477 LSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWL--------GSGDTNTPLWP----FLLR 529
            |...    :|.|..::.|...:.|:...|:|..:..|.        .||..:.|..|    ::..
 Worm   418 LMVK----MGFFCALFILPNVIELVCQCYKFMILTQWTRMTIDCKQQSGACHRPTPPQAEIYMTA 478

  Fly   530 AFMELMLGICCFAWVLGPSISTLYKRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVS 594
            ....|..|..|..|||.......:|..:..|                          .|:|..|.
 Worm   479 VISSLATGFSCLMWVLSAKTVHAWKNFIFCG--------------------------MCSSAPVK 517

  Fly   595 YHSVRTS--------MASVPLPPSPYKLKTSP 618
             :.:..|        .|..|.||...::.|:|
 Worm   518 -NPIEPSTRPLLEPPTAPPPQPPVYMQMATNP 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	44/127 (35%)
		7tm_4	223..544	CDD:304433	76/335 (23%)
lin-17	NP_001021813.1	CRD_LIN_17	25..144	CDD:143563	44/132 (33%)
		Frizzled	195..506	CDD:279827	80/348 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167738
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840