Sequence 1: | NP_511068.2 | Gene: | fz4 / 31659 | FlyBaseID: | FBgn0027342 | Length: | 705 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_032084.2 | Gene: | Fzd8 / 14370 | MGIID: | 108460 | Length: | 685 | Species: | Mus musculus |
Alignment Length: | 734 | Identity: | 177/734 - (24%) |
---|---|---|---|
Similarity: | 281/734 - (38%) | Gaps: | 191/734 - (26%) |
- Green bases have known domain annotations that are detailed below.
Fly 1 MKPTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMP 65
Fly 66 NLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTP--KAPVHAIGPCRSLCESVRI 128
Fly 129 RCHPVLQGFGFPWPPALDCDKFPRENNHETMCME------------GPGELHQPQQEQDLYGLPG 181
Fly 182 QGIPGGLGGKLPM---------------DCSGLAKSHLYVRLPRSGRCAPL-----CEADILFTP 226
Fly 227 AEKH-----------------------------LAEIWVSTWAYAALGLALVATVCLLASDGSRL 262
Fly 263 ASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTAC------------------------GT 300
Fly 301 DPQAPN-----------ESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSP 354
Fly 355 DSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGAC 419
Fly 420 FVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSG 484
Fly 485 IGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTP----LWP----------FLLRAFMELM 535
Fly 536 LGICCFAWV-LGPSIST---LYKR--QVSNGKMVKHTSAGAATGHL-------DGHSSSRGSHAA 587
Fly 588 CNSTVVSYHSVRTSMASVP 606 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
fz4 | NP_511068.2 | CRD_FZ4 | 43..169 | CDD:143557 | 49/139 (35%) |
7tm_4 | 223..544 | CDD:304433 | 85/401 (21%) | ||
Fzd8 | NP_032084.2 | CRD_FZ8 | 31..155 | CDD:143570 | 47/135 (35%) |
Palmitate-binding groove | 71..78 | 3/6 (50%) | |||
Wnt-binding | 95..100 | 1/4 (25%) | |||
Wnt-binding | 147..152 | 2/4 (50%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 155..223 | 13/74 (18%) | |||
7tmF_FZD8 | 264..616 | CDD:320378 | 87/387 (22%) | ||
TM helix 1 | 273..298 | CDD:320378 | 5/25 (20%) | ||
TM helix 2 | 307..328 | CDD:320378 | 6/25 (24%) | ||
TM helix 3 | 395..417 | CDD:320378 | 11/21 (52%) | ||
TM helix 4 | 438..454 | CDD:320378 | 3/15 (20%) | ||
TM helix 5 | 476..499 | CDD:320378 | 6/22 (27%) | ||
TM helix 6 | 529..554 | CDD:320378 | 6/28 (21%) | ||
TM helix 7 | 577..602 | CDD:320378 | 7/24 (29%) | ||
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 606..611 | 0/4 (0%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 631..656 | 5/24 (21%) | |||
PDZ-binding | 683..685 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D237456at33208 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
3 | 2.820 |