DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fz4 and Fzd8

DIOPT Version :9

Sequence 1:NP_511068.2 Gene:fz4 / 31659 FlyBaseID:FBgn0027342 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_032084.2 Gene:Fzd8 / 14370 MGIID:108460 Length:685 Species:Mus musculus


Alignment Length:734 Identity:177/734 - (24%)
Similarity:281/734 - (38%) Gaps:191/734 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKPTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMP 65
            ::.|.:|..|.|:        ..:||..:||:...:         |:.|.:.:|:.||||.|.||
Mouse     7 LEVTSLLAALAVL--------QRSSGAAAASAKELA---------CQEITVPLCKGIGYNYTYMP 54

  Fly    66 NLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTP--KAPVHAIGPCRSLCESVRI 128
            |...::.|.:....:..|.||:|..||..||.|||:.|.|:|..  |.|   :.||||:||..:.
Mouse    55 NQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKP---LPPCRSVCERAKA 116

  Fly   129 RCHPVLQGFGFPWPPALDCDKFPRENNHETMCME------------GPGELHQPQQEQDLYGLPG 181
            .|.|:::.:||.||..:.||:.|.:.|.:|:||:            .|..|..|..       ||
Mouse   117 GCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPP-------PG 174

  Fly   182 QGIPGGLGGKLPM---------------DCSGLAKSHLYVRLPRSGRCAPL-----CEADILFTP 226
            :..|.|.|...|.               |.:....|......|..|..||.     |.|.::...
Mouse   175 EQPPSGSGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVS 239

  Fly   227 AEKH-----------------------------LAEIWVSTWAYAALGLALVATVCLLASDGSRL 262
            :|:|                             ....|:..|:.... ::..|||.....|..|.
Mouse   240 SERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCF-VSTFATVSTFLIDMERF 303

  Fly   263 ASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTAC------------------------GT 300
            ...:     .|:|:   |:..|::|:.||.:.|....||                        |.
Mouse   304 KYPE-----RPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAAGAGAAGA 363

  Fly   301 DPQAPN-----------ESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSP 354
            ...:|.           |..:..:....|.|..|||:.|:||||:..||.:|.|.|         
Mouse   364 GASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTW--------- 419

  Fly   355 DSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGAC 419
                       |..:..|..:...|    ..:.:....||.:|:.::.||:....||.|.:.|.|
Mouse   420 -----------FLAAGMKWGNEAIA----GYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGIC 469

  Fly   420 FVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSG 484
            :|||||...|:..|..|:..|...|:|.|::|::...|.:.:::.....:...:|::|...    
Mouse   470 YVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIR---- 530

  Fly   485 IGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTP----LWP----------FLLRAFMELM 535
            :|:|..:|.:..|:::..:.||..|...|  ....|.|    |.|          |:|:.||.|:
Mouse   531 LGLFTVLYTVPAAVVVACLFYEQHNRPRW--EATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLV 593

  Fly   536 LGICCFAWV-LGPSIST---LYKR--QVSNGKMVKHTSAGAATGHL-------DGHSSSRGSHAA 587
            :||....|| .|.::.:   |..|  ..|.|..|...:.|:..|..       .||....||..:
Mouse   594 VGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGSGPGPGGGGGHGGGGGSLYS 658

  Fly   588 CNSTVVSYHSVRTSMASVP 606
            ..||.:::.|...|..|.|
Mouse   659 DVSTGLTWRSGTASSVSYP 677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz4NP_511068.2 CRD_FZ4 43..169 CDD:143557 49/139 (35%)
7tm_4 223..544 CDD:304433 85/401 (21%)
Fzd8NP_032084.2 CRD_FZ8 31..155 CDD:143570 47/135 (35%)
Palmitate-binding groove 71..78 3/6 (50%)
Wnt-binding 95..100 1/4 (25%)
Wnt-binding 147..152 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..223 13/74 (18%)
7tmF_FZD8 264..616 CDD:320378 87/387 (22%)
TM helix 1 273..298 CDD:320378 5/25 (20%)
TM helix 2 307..328 CDD:320378 6/25 (24%)
TM helix 3 395..417 CDD:320378 11/21 (52%)
TM helix 4 438..454 CDD:320378 3/15 (20%)
TM helix 5 476..499 CDD:320378 6/22 (27%)
TM helix 6 529..554 CDD:320378 6/28 (21%)
TM helix 7 577..602 CDD:320378 7/24 (29%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 606..611 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..656 5/24 (21%)
PDZ-binding 683..685
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D237456at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.