DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz4 and Fzd5

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001036124.1	Gene:	Fzd5 / 14367	MGIID:	108571	Length:	585	Species:	Mus musculus

Alignment Length:	643	Identity:	168/643 - (26%)
Similarity:	272/643 - (42%)	Gaps:	113/643 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNL 67
            |..:|.||:..|:            ..|:::|.:|       .|:.|.:.|||.||||.|.|||.
Mouse     9 PPSLLLLLLAQLV------------GRAAAASKAP-------VCQEITVPMCRGIGYNLTHMPNQ 54

  Fly    68 VGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVH-AIGPCRSLCESVRIRCH 131
            ..::.|.:....:..|.||:|..||..|:.|||:.|.|:|.|  ..| .:.||||:||..:..|.
Mouse    55 FNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLP--DYHKPLPPCRSVCERAKAGCS 117

  Fly   132 PVLQGFGFPWPPALDCDKFP-RENNHETMCME---GPGELHQPQQ---EQDLYGLPGQGIPGG-- 187
            |:::.:||.||..:.||:.| ...:.|.:||:   .......|:.   :..|.|.||....||
Mouse   118 PLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGGEC 182

  Fly   188 -LGGKLPMDCSG-----LAKSH-LY--VRLPRSGRCAPLCEADILFTPAEKHLAEIWVSTWAYAA 243
             .||.....|..     |.:|| ||  ||..:...||..|... .|:|.|:..|..|:..|:...
Mouse   183 PSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQP-SFSPDERTFATFWIGLWSVLC 246

  Fly   244 LGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAP 305
            . ::...||.....|..|....:     .|:|:   |:..|:||:.||.:||....||..:
Mouse   247 F-ISTSTTVATFLIDMERFRYPE-----RPIIFLSACYLCVSLGFLVRLVVGHASVACSRE---- 301

  Fly   306 NESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSP 370
             .|.:..:....|.|..|||:.|:||||:..||.:|.|.|             .:.....:|...
Mouse   302 -HSHIHYETTGPALCTVVFLLVYFFGMASSIWWVILSLTW-------------FLAAGMKWGNEA 352

  Fly   371 AKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVAT 435
            .    |..||       :....||.:|:.::...:....||.|.:.|.|:||||:..:|:..|..
Mouse   353 I----AGYAQ-------YFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLG 406

  Fly   436 PVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLL 500
            |:..|.:.|::.|::|::...|.:.:::.....:  .:|::|...    ||||..:|.:..::::
Mouse   407 PLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKT--DKLEKLMIR----IGIFTLLYTVPASIVV 465

  Fly   501 LAVIYEFANIDVW------------LGSGDTNTPLWPFLLRAFMELMLGICCFAWVLGPSISTLY 553
            ...:||....:.|            .|........|..:|:.||.|::||....|:........:
Mouse   466 ACYLYEQHYRESWEAALTCACPGPDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESW 530

  Fly   554 KRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSP 611
            :|..|      .....:..||..|.:.:.|.:|..::.:..    ||.      ||.|
Mouse   531 RRFTS------RCCCSSRRGHKSGGAMAAGDYAEASAALTG----RTG------PPGP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	47/130 (36%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	80/335 (24%)
Fzd5	NP_001036124.1	CRD_FZ5	29..156	CDD:143569	48/135 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..182		7/25 (28%)
		7tm_GPCRs	225..535	CDD:333717	82/351 (23%)
		TM helix 1	235..259	CDD:320095	5/24 (21%)
		TM helix 2	268..289	CDD:320095	7/25 (28%)
		TM helix 3	316..338	CDD:320095	11/21 (52%)
		TM helix 4	359..375	CDD:320095	3/15 (20%)
		TM helix 5	397..420	CDD:320095	5/22 (23%)
		TM helix 6	448..473	CDD:320095	7/28 (25%)
		TM helix 7	496..521	CDD:320095	7/24 (29%)
		PDZ-binding. /evidence=ECO:0000250	582..584
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810