DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz4 and Fzd4

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_032081.3	Gene:	Fzd4 / 14366	MGIID:	108520	Length:	537	Species:	Mus musculus

Alignment Length:	550	Identity:	189/550 - (34%)
Similarity:	279/550 - (50%)	Gaps:	93/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCT 108
            |:|:.|||.||:.:|||.|.||||||:|:|||.|..|.||.|||:|.|||||:.|||:.||||||
Mouse    43 RRCDPIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCT 107

  Fly   109 PKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQE 173
            .|..: .||||..:|.||:.||.|||:.|||.||..|:|.|||.:|:|..|||||||:...|
Mouse   108 EKINI-PIGPCGGMCLSVKRRCEPVLREFGFAWPDTLNCSKFPPQNDHNHMCMEGPGDEEVP--- 168

  Fly   174 QDLYGLPGQGIPGGLGGKLPM----DCSGL-AKSHLYVRLPRSGRCAPLCEADI-LFTPAEKHLA 232
                          |..|.|:    :|..: :.|..|:.:.||..|...|..|. |::.:.|...
Mouse   169 --------------LPHKTPIQPGEECHSVGSNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFT 219

  Fly   233 EIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRT 294
            :||::.||.... ::...||.....|.||.:..:     .|:|:   |:|:.::.:.||..|||.
Mouse   220 DIWMAVWASLCF-ISTTFTVLTFLIDSSRFSYPE-----RPIIFLSMCYNIYSIAYIVRLTVGRE 278

  Fly   295 GTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGW---------HRDIR 350
            ..:|..:..|  |.:|..:||.|..||.:||:.|:||||:..||.:|.|.|         |..|.
Mouse   279 RISCDFEEAA--EPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIE 341

  Fly   351 RHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADEL 415
            .||  |..|:                               .||.:||.:|..:::.|.||||||
Mouse   342 MHS--SYFHI-------------------------------AAWAIPAVKTIVILIMRLVDADEL 373

  Fly   416 LGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAH 480
            .|.|:||||:..||...|..|:|.|.:.|::.:.:|.:...:.:..|:.....:  .:|::|...
Mouse   374 TGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKT--DKLERLMVK 436

  Fly   481 SSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTPLWPFLLRAFMELMLGICCFAWVL 545
                ||:|..:|.:....::....||.:|..::..|.| ::.:...:|:.||.|::||....|:.
Mouse   437 ----IGVFSVLYTVPATCVIACYFYEISNWALFRYSAD-DSNMAVEMLKIFMSLLVGITSGMWIW 496

  Fly   546 GPSISTLY------KRQVSNGKMVKHTSAG 569
              |..||:      .|.|::|| ||....|
Mouse   497 --SAKTLHTWQKCSNRLVNSGK-VKREKRG 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	75/124 (60%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	91/332 (27%)
Fzd4	NP_032081.3	CRD_FZ4	42..167	CDD:143557	75/124 (60%)
		Frizzled	210..509	CDD:279827	95/348 (27%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	499..504		2/4 (50%)
		PDZ-binding	535..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850640
Domainoid	1	1.000	147	1.000	Domainoid score	I4484
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109675
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750