DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and Fzd3

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_067433.1	Gene:	Fzd3 / 14365	MGIID:	108476	Length:	666	Species:	Mus musculus

Alignment Length:	721	Identity:	175/721 - (24%)
Similarity:	280/721 - (38%)	Gaps:	166/721 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPK 110
            ||.|.:.||:.:.||.|.||||:.:..|......::.|.|::..|||...:.||||.|.|:|...
Mouse    28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEY 92

  Fly   111 APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQD 175
            ..|..  |||.||:.....|..:::.||.|||..::|.:||.       |.|....|    .:.:
Mouse    93 GRVTL--PCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPD-------CDEPYPRL----VDLN 144

  Fly   176 LYGLPGQGIPGGL----GGKLPMDCS---GLAKSHLYVRLPRSGRCAPLCEADILFTPAEKHLAE 233
            |.|.|.:|.|..:    |...|.:..   .|..|.|:||     .|:|.| .::.|...|...|.
Mouse   145 LVGDPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVR-----DCSPPC-PNMYFRREELSFAR 203

  Fly   234 IWVSTWAYAALGLALVATVCLLAS---------DGSRLASAKWSRLLSPLIW---CHNMVTLGWA 286
            .::          .|::.:||.|:         |.:|....:     .|:|:   |:.||:|.:.
Mouse   204 YFI----------GLISIICLSATLFTFLTFLIDVTRFRYPE-----RPIIFYAVCYMMVSLIFF 253

  Fly   287 VRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRR 351
            :.|:: ....||.....|..::.....|..|.:|..:|::.|:|.||...||.:|.:.|..
Mouse   254 IGFLL-EDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFL---- 313

  Fly   352 HSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELL 416
                    ..:|.  .||.|....|......          |||:|...|..::....::.|.:.
Mouse   314 --------AAVPK--WGSEAIEKKALLFHAS----------AWGIPGTLTIILLAMNKIEGDNIS 358

  Fly   417 GACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTK-EI-LRNSNALSVQQQLQQLSA 479
            |.||||.....||:..|..|:..|.:.|...|::|.:...|.: || |...|    |.:|.:...
Mouse   359 GVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKEN----QDKLVKFMI 419

  Fly   480 HSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDT----------------------NTP 522
            .    ||:|..:|.:...:::....||.|...:|    :|                      ...
Mouse   420 R----IGVFSILYLVPLLVVIGCYFYEQAYRGIW----ETTWIQERCREYHIPCPYQVTQMSRPD 476

  Fly   523 LWPFLLRAFMELMLGI----------CCFAW-----------VLGPSISTLYKRQVSNGKM---- 562
            |..||::..|.|::||          .||.|           ::..|...|.:...:...:
Mouse   477 LILFLMKYLMALIVGIPSIFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDPN 541

  Fly   563 --VKHTSAGAATGHLDGHSSS---------RGSHAACNSTVVSYH-SVRTSMASVPLPPSPYKLK 615
              :...|.|.:|.....|:||         |....:.:|.|.||| |:..|......|.|...::
Mouse   542 TPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSVHSKVSSYHGSLHRSRDGRYTPCSYRGME 606

  Fly   616 TSPGTGSISLNQMSNYSLGRSVHHQQRHSPHHHHHQQQQHHQFHPHHN----HQHHSTSSHRLYY 676
            .....||:|  :::::|         |||..|..::|.:|.......|    |..|.||.:|:..
Mouse   607 ERLPHGSMS--RLTDHS---------RHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIE 660

  Fly   677 PPGSYA 682
            ..|:.|
Mouse   661 EDGTSA 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	43/122 (35%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	81/377 (21%)
Fzd3	NP_067433.1	CRD_FZ3	24..150	CDD:143558	45/134 (34%)
		Frizzled	193..512	CDD:279827	81/370 (22%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	502..507		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..666		33/138 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810