DRSC/TRiP Functional Genomics Resources

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Protein Alignment fz4 and FZD10

DIOPT Version :10

Sequence 1:NP_511068.2 Gene:fz4 / 31659 FlyBaseID:FBgn0027342 Length:705 Species:Drosophila melanogaster
Sequence 2:NP_009128.1 Gene:FZD10 / 11211 HGNCID:4039 Length:581 Species:Homo sapiens


Alignment Length:604 Identity:174/604 - (28%)
Similarity:273/604 - (45%) Gaps:105/604 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 SASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSS 93
            |.::.||...|.|...:|:.|.|.||:.||||.|.||||:|:|.|.:....|..||||:||.|..
Human    17 SCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHG 81

  Fly    94 QLKLFLCAAYVPMCTPK--APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNH 156
            .|:.|||:.|.||||.:  .|:.|   ||.:||..|::|.|:::.|.|.||.:|||.|.|.:|:.
Human    82 HLRFFLCSLYAPMCTEQVSTPIPA---CRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDP 143

  Fly   157 ETMCMEGPGE--------------LHQPQ-----QEQDLY-GLPGQGIPGGLGGKLPMDCSGLAK 201
            ..:|||.|..              |.:||     ||..|. |.||:|           .|....|
Human   144 NYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRG-----------GCDNPGK 197

  Fly   202 SHLYVRLPRSGRCAPLCE--ADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLAS 264
            .|   .:.:|..|||||.  .|:.::..:|..|.:|::.||.... .:...||.....|.:|...
Human   198 FH---HVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCF-FSSAFTVLTFLIDPARFRY 258

  Fly   265 AKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLM 326
            .:     .|:|:   |:.:.::|:.:|...|....||..|   ..:..:..:||.:..|..|||:
Human   259 PE-----RPIIFLSMCYCVYSVGYLIRLFAGAESIACDRD---SGQLYVIQEGLESTGCTLVFLV 315

  Fly   327 RYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCF 391
            .||||||:..||.||.|.|.....:    ..||..|.:|                    :::...
Human   316 LYYFGMASSLWWVVLTLTWFLAAGK----KWGHEAIEAN--------------------SSYFHL 356

  Fly   392 VAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHC 456
            .||.:||.:|..::|.|.|..|||.|.|:||:....||...|..|:.||.:.|:..::||::...
Human   357 AAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALF 421

  Fly   457 RTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVW-------- 513
            ..:.:::.....:  .:|::|...    ||:|..:|.:....::....||..|:|.|        
Human   422 HIRRVMKTGGENT--DKLEKLMVR----IGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHK 480

  Fly   514 -LGSGDTNT----------PLWPFLLRAFMELMLGICCFAWVLGPSISTLYK-RQVSNGKMVKHT 566
             ..:..|.|          .:..|:::.||.|::||....|:.  :..||.. :||.:.::.|.:
Human   481 CKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIW--TSKTLQSWQQVCSRRLKKKS 543

  Fly   567 SAGAATGHLDGHSSSRGSH 585
            ....|:....|....:..|
Human   544 RRKPASVITSGGIYKKAQH 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fz4NP_511068.2 CRD_FZ4 43..169 CDD:143557 58/141 (41%)
7tmF_Frizzled_SMO 222..557 CDD:320089 86/357 (24%)
TM helix 1 231..256 CDD:320089 6/24 (25%)
TM helix 2 268..289 CDD:320089 4/23 (17%)
TM helix 3 321..347 CDD:320089 15/25 (60%)
TM helix 4 388..404 CDD:320089 5/15 (33%)
TM helix 5 426..455 CDD:320089 9/28 (32%)
TM helix 6 481..508 CDD:320089 6/26 (23%)
TM helix 7 519..544 CDD:320089 8/34 (24%)
FZD10NP_009128.1 CRD_FZ10 30..156 CDD:143571 57/128 (45%)
7tmF_FZD10 217..535 CDD:320165 87/358 (24%)
TM helix 1 226..251 CDD:320165 6/25 (24%)
TM helix 2 260..281 CDD:320165 4/25 (16%)
TM helix 3 310..336 CDD:320165 15/25 (60%)
TM helix 4 353..369 CDD:320165 5/15 (33%)
TM helix 5 391..420 CDD:320165 9/28 (32%)
TM helix 6 440..467 CDD:320165 7/30 (23%)
TM helix 7 497..522 CDD:320165 6/24 (25%)
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 526..531 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 560..581 1/3 (33%)
PDZ-binding 579..581
Blue background indicates that the domain is not in the aligned region.

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