DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fz4 and fzd4

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_002936589.1	Gene:	fzd4 / 100497693	XenbaseID:	XB-GENE-478210	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	186/539 - (34%)
Similarity:	274/539 - (50%)	Gaps:	84/539 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCT 108
            |:|:.|||.||:.:|||.|.||||||:|:|.|.|..|.||.|||:|.|||||:.|||:.||||||
Frog    29 RRCDPIRISMCQNLGYNVTKMPNLVGHELQADAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCT 93

  Fly   109 PKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQE 173
            .|..: .||||..:|.||:.||.|||:.|||.||.:|:|.|||.:|:|..|||||||:...|...
Frog    94 EKINI-PIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDDEVPVHS 157

  Fly   174 QDLYGLPGQGIPGGLGGKLPMDCSGLA-KSHLYVRLPRSGRCAPLCEADI-LFTPAEKHLAEIWV 236
            :... |||:            ||:... .|..|..:.||..|...|..|. |::...|...:||:
Frog   158 KTPV-LPGE------------DCNSFGPNSDQYTWVKRSMNCVLKCGYDSGLYSRLSKEFTDIWM 209

  Fly   237 STWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTAC 298
            :.||.... ::...||.....|.||....:     .|:|:   |:|:.::.:.||..|||...:|
Frog   210 AVWASLCF-ISTAFTVLTFLIDSSRFCYPE-----RPIIFLSMCYNIYSIAYIVRLTVGRERISC 268

  Fly   299 GTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGW---------HRDIRRHSP 354
            ..:..|  |.:|..:||.|..||.:||:.|:||||:..||.:|.|.|         |..|..||
Frog   269 DFEEAA--EPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHS- 330

  Fly   355 DSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGAC 419
             |..|:                               .||.:||.:|..:::.|.||||||.|.|
Frog   331 -SYFHI-------------------------------AAWAIPAVKTIVILIMRLVDADELTGLC 363

  Fly   420 FVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSG 484
            :||||:..||...|..|:|.|.:.|::.:.:|.:...:.:..|:.....:  .:|::|...
Frog   364 YVGNQNIDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKT--DKLERLMVK---- 422

  Fly   485 IGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTPLWPFLLRAFMELMLGICCFAWVLGPSI 549
            ||:|..:|.:....::....||.:|.:|:..:.| ::.:...:|..||.|::||....|:.  |.
Frog   423 IGVFSVLYTVPATCVIACYFYEISNWNVFRYTAD-DSNMAVEMLNIFMSLLVGITSGMWIW--SA 484

  Fly   550 STLY------KRQVSNGKM 562
            .||:      .|.|::||:
Frog   485 KTLHTWQKCTNRLVNSGKV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	74/124 (60%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	91/332 (27%)
fzd4	XP_002936589.1	CRD_FZ4	28..153	CDD:143557	74/124 (60%)
		7tmF_FZD4	195..495	CDD:320166	95/349 (27%)
		TM helix 1	204..229	CDD:320166	6/25 (24%)
		TM helix 2	238..259	CDD:320166	5/25 (20%)
		TM helix 3	289..315	CDD:320166	13/25 (52%)
		TM helix 4	332..348	CDD:320166	6/46 (13%)
		TM helix 5	370..399	CDD:320166	8/28 (29%)
		TM helix 6	419..446	CDD:320166	7/30 (23%)
		TM helix 7	456..481	CDD:320166	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4531
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020