DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and smo

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_002931911.2	Gene:	smo / 100491644	XenbaseID:	XB-GENE-487420	Length:	815	Species:	Xenopus tropicalis

Alignment Length:	632	Identity:	130/632 - (20%)
Similarity:	215/632 - (34%)	Gaps:	153/632 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CETIRIEMC--RKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYD-CSSQLKLFLCAAYVPMC 107
            ||.::..:|  ..:.|..||......:..|.::...|..::.|.... |...::..|||.|:|.|
Frog    43 CEPLKYNVCLGSVLPYALTSTVLAEDSSTQEEIHDKLLLWSGLRNAPRCWDAIRPLLCAVYMPKC 107

  Fly   108 T-PKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDC--DKFPR--ENNHETMCMEGPGEL 167
            . .|..:    |.:|||::.|:.|..|.:..|  ||..|.|  |.||.  .|..:|:.....|:.
Frog   108 EGGKVEL----PSQSLCQTTRVPCAIVARERG--WPDFLKCTTDHFPDGCSNEIQTVKFNSSGQC 166

  Fly   168 HQPQQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLCEADILFTPAEKHLA 232
            ..|....|......:.:.|                           |...|: :.|||..|....
Frog   167 EAPLVRTDNPKSWYEDVEG---------------------------CGIQCQ-NPLFTKKEHREM 203

  Fly   233 EIWVSTWAYAALGLALVATVCLLASDGSRLASAKW---SRLLSPLIW----CHNMVTLGWAVRFM 290
            .::::.::...: .....|:....||        |   :|..:.:::    |..:.::||..:||
Frog   204 HVYIAIFSSVTI-FCTFFTLATFLSD--------WKNSNRYPAVILFYVNACFFVGSIGWLAQFM 259

  Fly   291 VG-RTGTAC---GT----DPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHR 347
            .| |....|   ||    :|.: ||:|         ||..:|::.||..|:...|:.:|...||.
Frog   260 DGARDEIVCRGDGTMRLGEPTS-NETL---------SCVIIFVIVYYAMMSGVIWFVMLTYAWHT 314

  Fly   348 DIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLT-QNNFVCFVAWGLPAFQTSAVIVARFVD 411
            ..:                        :..|..|.|: :.::...:.|.:|...|.|::....||
Frog   315 SFK------------------------ALGTTHQPLSGKTSYFHLITWSIPFVLTVAILAVAQVD 355

  Fly   412 ADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKE----ILRNSNALSVQQ 472
            .|.:.|.||||.::.......|..|:....|.|...||.|.:.....|.    :|....|..:.:
Frog   356 GDSVSGICFVGYKNYHYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINE 420

  Fly   473 QLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGS--------------GDTNTPL 523
            .:.:|........|..|..:|  |.      .|:|.|...|..|              ..||.|:
Frog   421 TMLRLGIFGFLAFGFVLITFG--CH------FYDFFNQAEWERSFREYVLCEANVTIAEQTNKPI 477

  Fly   524 -------WPFLL----RAFMELMLGICCFAWVLGPSISTLYKRQVSNGKMVKHTSAGAATGHLDG 577
                   .|.||    ..|.....||....||...:...::||               |...:.|
Frog   478 PECEIKNRPSLLVEKINLFAMFGTGISMSTWVWTKATIIIWKR---------------AWCRILG 527

  Fly   578 HSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSPYKLKTSPGTGSIS 624
            .|.........:..:....|.|..:.:.|.....:.|.|....|.::
Frog   528 RSDDEPKRIKKSKMIAKAFSKRKELLNNPEKELSFSLHTVSHEGPVA 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	35/130 (27%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	77/365 (21%)
smo	XP_002931911.2	CRD_SMO	39..169	CDD:143560	35/131 (27%)
		7tmF_SMO_homolog	193..523	CDD:320158	82/395 (21%)
		TM helix 1	202..227	CDD:320158	1/25 (4%)
		TM helix 2	237..258	CDD:320158	3/20 (15%)
		TM helix 3	288..314	CDD:320158	7/25 (28%)
		TM helix 4	332..348	CDD:320158	3/15 (20%)
		TM helix 5	370..399	CDD:320158	7/28 (25%)
		TM helix 6	421..448	CDD:320158	6/34 (18%)
		TM helix 7	484..509	CDD:320158	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010