DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and fzd6

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001238809.2	Gene:	fzd6 / 100490861	XenbaseID:	XB-GENE-478813	Length:	724	Species:	Xenopus tropicalis

Alignment Length:	627	Identity:	150/627 - (23%)
Similarity:	240/627 - (38%)	Gaps:	132/627 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQ 73
            :|:|.||.|.:...|                   ...||.|.:..|..:.||.|..|||:.:..|
Frog    25 VLLVTLLLPLVQSHS-------------------LFTCEPITVPRCTGMNYNMTFFPNLLEHYDQ 70

  Fly    74 TDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFG 138
            ......::.|.||:...||.::..|||.|:||.||  .|.|...|||||||.|...|..:::.||
Frog    71 DIAALRMEPFLPLLNLHCSPEVHTFLCRAFVPECT--EPKHITMPCRSLCERVYSDCKNLIETFG 133

  Fly   139 FPWPPALDCDKFPRENNHETMCMEGPGELH----QPQQ---------EQDLYGLPGQGIPGGLGG 190
            ..||..|:||:....||.::....||.:.|    .|:|         .|.|....|.|..
Frog   134 ITWPAELECDRMRDCNNSQSKGGGGPDDPHDALRHPEQVHRDFKFWCPQHLKTSQGSGFK----- 193

  Fly   191 KLPMDCSGLAKSHLYVRLPRSGRCAPLCEADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLL 255
            .|.:|                 ||||.| .::.|...:...|:.::...:...|.:.|. ||...
Frog   194 FLGVD-----------------RCAPPC-PNMYFKKVDMDFAKYFIGVISIICLCVTLF-TVLTF 239

  Fly   256 ASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSN 317
            ..|..|....:     .|:|:   |::||:|.:.:.|::|.: ..|....:........|.|..:
Frog   240 LIDVQRFRYPE-----RPIIFYSVCYSMVSLMYVIGFLMGNS-IVCNEREENFASGDTVVLGSQH 298

  Fly   318 ASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQD 382
            .:|..:|::.|:..||...||.:|.:.|                    |..:..|.:.....|:.
Frog   299 KACTIIFMLLYFCTMAGTIWWVMLTITW--------------------FLAAGRKWSCEAIEQKS 343

  Fly   383 LTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIF-GSM 446
            |..:.    ||||:|...|..::....|:.|.:.|.||||....:.....|..|: |..:| |..
Frog   344 LWFHG----VAWGIPGILTIILLAMNKVEGDNISGVCFVGLYDQEVSIYFVLLPL-CLCVFIGLS 403

  Fly   447 NLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANID 511
            .|::|.:.....::::::..  ..||:|::....    ||:|...|.:...:||...:||.....
Frog   404 LLLAGIISLNNVRQVIQHDE--RNQQKLKKFMIR----IGVFSGTYLVPLVILLGCYVYEQVYRS 462

  Fly   512 VWL------GSGDTNTP------------LWPFLLRAFMELMLGICCFAWVLGPSISTLY----- 553
            .|.      ...|.:.|            |..|:.:..|.|::||....||......:.:
Frog   463 SWEMTWVSDNCQDYHIPCPFQLKNPARPDLGLFITKYIMTLIVGISAIFWVGSKKTCSEWVNFFN 527

  Fly   554 --KRQ--VSNGKMVKHTSA------GAATGHLDGHSSSRGSH 585
              ::|  :|..:.|...|.      .|...|.....|..|||
Frog   528 RSRKQDPISESRRVLQESCEFFLKHNAKVKHKKKKHSKSGSH 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	47/129 (36%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	72/342 (21%)
fzd6	NP_001238809.2	CRD_FZ6	39..172	CDD:143559	49/153 (32%)
		7tmF_FZD6	207..527	CDD:320160	74/357 (21%)
		TM helix 1	217..241	CDD:320160	5/24 (21%)
		TM helix 2	250..271	CDD:320160	6/25 (24%)
		TM helix 3	302..324	CDD:320160	7/21 (33%)
		TM helix 4	345..361	CDD:320160	6/19 (32%)
		TM helix 5	383..406	CDD:320160	5/23 (22%)
		TM helix 6	437..459	CDD:320160	7/21 (33%)
		TM helix 7	488..513	CDD:320160	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910