Protein Alignment fz4 and fzd5

DIOPT Version :10

• Sequence 1: NP_511068.2
• Gene: fz4 / 31659
• FlyBaseID: FBgn0027342
• Length: 705
• Species: Drosophila melanogaster
• Sequence 2: XP_004917802.1
• Gene: fzd5 / 100488110
• XenbaseID: XB-GENE-479707
• Length: 559
• Species: Xenopus tropicalis
• Alignment Length: 595
• Identity: 162/595 - (27%)
• Similarity: 258/595 - (43%)
• Gaps: 113/595 - (18%)

  Fly    38 PEIPAFRQ--CETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLC 100
            |..||.:.  |:.|.:.||:.||||.|.|||...::.|.:....:..|.||:...||..||.|||
 Frog    23 PVRPASKAIVCQEITVPMCKGIGYNHTYMPNQFNHDTQDEAGMEVHQFWPLVVIQCSLDLKFFLC 87

  Fly   101 AAYVPMCTP--KAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCME- 162
            :.|.|:|.|  :.|   :.||||:||..:..|.|:::.:||.||..::||:.|...:.:|:||:
 Frog    88 SMYTPICLPDYRKP---LPPCRSVCERAKAGCSPLMRKYGFAWPERMNCDRLPEHGDPDTLCMDY 149

  Fly   163 -------GPGELHQPQQEQDLYGLPGQGIPGGLGGKLP-MDCSGLAK-----------SH-LYVR 207
                   .|...|.|:.                  |.| .||.|:.|           || ||.|
 Frog   150 NWTETTTTPPPTHPPKV------------------KTPSSDCDGVCKCREPFLSITRESHPLYNR 196

  Fly   208 LPRSGR---CAPLCEADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSR 269
            : ::|:   ||..| ....||..||..|..|:..|:.... ::...||.....|..|....:
 Frog   197 I-KTGQVPNCAMPC-FQPYFTQDEKTFATFWIGLWSILCF-ISTFTTVATFLIDMERFRYPE--- 255

  Fly   270 LLSPLIW---CHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFG 331
              .|:|:   |:..|::|:.||.:||....||       |:..:..:....|.|..|||:.|:||
 Frog   256 --RPIIFLSACYLFVSIGYIVRLIVGHENVAC-------NKDHIHYETTGPALCTVVFLLIYFFG 311

  Fly   332 MAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGL 396
            ||:..||.:|...|                    |..:..|..:...|    :.:.:....||.:
 Frog   312 MASSIWWVILTFTW--------------------FLAAGMKWGNEAIA----SYSQYFHMAAWLI 352

  Fly   397 PAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEI 461
            |:.::.||:....||.|.:.|.||||||:...|:..|..|:..|...|:|.|::|::...|.:.:
 Frog   353 PSVKSIAVLALSSVDGDPVAGICFVGNQNLDNLRGFVLAPLVVYLFTGTMFLLAGFVSLFRIRSV 417

  Fly   462 LRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTP---- 522
            ::.....:  .:|::|...    ||||..:|.:...:::...|||....:.|..:.:.:.|
 Frog   418 IKQGGTKT--DKLEKLMIR----IGIFSVLYTVPATIVVACYIYEQHYREHWEKAHNCSCPGDKK 476

  Fly   523 -----LWPFLLRAFMELMLGICCFAWVLGPSISTLYKRQVS----NGKMVK---HTSAGAATGHL 575
                 ...|:|:.||.|::||....|:........:||...    |.|.:.   ::.|..|....
 Frog   477 RYRPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWKRFTGRCCRNSKPINASAYSEASRALTAR 541

  Fly   576 DGHSSSRGSH 585
            .|.|||...|
 Frog   542 TGLSSSTLHH 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	47/137 (34%)
		7tmF_Frizzled_SMO	222..557	CDD:320089	86/346 (25%)
		TM helix 1	231..256	CDD:320089	5/24 (21%)
		TM helix 2	268..289	CDD:320089	6/23 (26%)
		TM helix 3	321..347	CDD:320089	12/25 (48%)
		TM helix 4	388..404	CDD:320089	3/15 (20%)
		TM helix 5	426..455	CDD:320089	8/28 (29%)
		TM helix 6	481..508	CDD:320089	8/26 (31%)
		TM helix 7	519..544	CDD:320089	8/33 (24%)
fzd5	XP_004917802.1	CRD_FZ5	29..153	CDD:143569	46/126 (37%)
		7tmF_FZD5	212..517	CDD:320377	86/347 (25%)
		TM helix 1	221..246	CDD:320377	5/25 (20%)
		TM helix 2	255..276	CDD:320377	6/25 (24%)
		TM helix 3	301..327	CDD:320377	12/45 (27%)
		TM helix 4	344..360	CDD:320377	3/15 (20%)
		TM helix 5	382..411	CDD:320377	8/28 (29%)
		TM helix 6	431..458	CDD:320377	9/30 (30%)
		TM helix 7	478..503	CDD:320377	7/24 (29%)