DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and Fzd7

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001258114.1	Gene:	Fzd7 / 100360552	RGDID:	2321905	Length:	572	Species:	Rattus norvegicus

Alignment Length:	625	Identity:	160/625 - (25%)
Similarity:	249/625 - (39%)	Gaps:	133/625 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNE 71
            ||.||:.||  ....:.|...|.......|   :|....|:.|.|.:|..|.||:|.:|||:|:.
  Rat    15 LCALVLALL--GALPTDTGAQPYHGEKGIS---VPDHGFCQPISIPLCTDIAYNQTILPNLLGHT 74

  Fly    72 MQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQG 136
            .|.|....:..|.||::..||.:|:.|||:.|.|:||  ....||.|||||||..|..|..::..
  Rat    75 NQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCT--VLDQAIPPCRSLCERARQGCEALMNK 137

  Fly   137 FGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLYGLPGQGIPGGLGG----------- 190
            |||.||..|.|:.||         :.|.||:...|...|     |.   ||.||
  Rat   138 FGFQWPERLRCENFP---------VHGAGEICVGQNTSD-----GS---GGAGGSPTAYPTAPYL 185

  Fly   191 -----------------KLPMDCSGLAK--SHLYVRLPRSGRCAPLCEAD-----ILFTPAEKHL 231
                             ..|..|....|  .:|..|......|...||..     :.|...|:..
  Rat   186 PDPPFTAMSPSDGRGRWSFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRF 250

  Fly   232 AEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMVGR 293
            |.:||..|:.......|...:..|..      ..::|....|:|:   |:.||.:.....|::..
  Rat   251 ARLWVGVWSVLCCASTLFTVLTYLVD------MRRFSYPERPIIFLSGCYFMVAVAHVAGFLLED 309

  Fly   294 TGTACGTDPQAPNESLLTV-DGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSK 357
            .....   .:..::...|| .|.....|..:|::.|:||||:..||.:|.|.|..     :...|
  Rat   310 RAVCV---ERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFL-----AAGMK 366

  Fly   358 -GHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFV 421
             ||..|.:|                    :.:....||.:||.:|..::....||.|.|.|.|:|
  Rat   367 WGHEAIEAN--------------------SQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYV 411

  Fly   422 GNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIG 486
            |..|..||:..|..|:|.|...|:..|::|::...|.:.|:::....:  ::|::|...    ||
  Rat   412 GLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKT--EKLEKLMVR----IG 470

  Fly   487 IFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNT--------------PLWP----FLLRAFME 533
            :|..:|.:...::|....||.|..:.|..:....|              |:.|    |:::..|.
  Rat   471 VFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFSPMSPDFTVFMIKYLMT 535

  Fly   534 LMLGICCFAWV-LGPSIST---LYKRQVSNGKMVKHTSAG 569
            :::||....|: .|.::.:   .|.|       :.|:|.|
  Rat   536 MIVGITTGFWIWSGKTLQSWRRFYHR-------LSHSSKG 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	50/125 (40%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	78/343 (23%)
Fzd7	NP_001258114.1	CRD_FZ7	45..169	CDD:143575	52/139 (37%)
		7tmF_FZD7	241..571	CDD:320374	85/375 (23%)
		TM helix 1	251..275	CDD:320374	5/23 (22%)
		TM helix 2	284..305	CDD:320374	5/20 (25%)
		TM helix 3	335..357	CDD:320374	9/21 (43%)
		TM helix 4	378..394	CDD:320374	5/15 (33%)
		TM helix 5	416..439	CDD:320374	7/22 (32%)
		TM helix 6	470..492	CDD:320374	6/21 (29%)
		TM helix 7	521..546	CDD:320374	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810