DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and corin

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	XP_009295418.2	Gene:	corin / 100320926	ZFINID:	ZDB-GENE-060224-3	Length:	1036	Species:	Danio rerio

Alignment Length:	674	Identity:	151/674 - (22%)
Similarity:	217/674 - (32%)	Gaps:	229/674 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SGNPSASSSSSSPPEIPA--------FRQCETIRIEMCRKIGYNETSMPNLVGNEMQ--TDVEYT 79
            ||....||:|..|.....        ...||.|.:|:|..:.||.|..||.:|::.|  |.|.:.
Zfish   420 SGQSGCSSTSCCPGNTSCDLRTAGNNCSDCEPISLEICMNLPYNTTRFPNYLGHQSQKETSVSWE 484

  Fly    80 LQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPA 144
            ...|..|::.:|...|..|.|...||||.| .....:.||||||.:.:.||..||...|..||..
Zfish   485 SSLFPALVQTNCYKYLMFFACTVLVPMCDP-VTQQRVPPCRSLCRNSKDRCESVLGIVGLQWPED 548

  Fly   145 LDCDKFPRENNHETMCMEGPGELHQ--PQQ---------------------------------EQ 174
            .||.:||.|....:.|:....::::  |..                                 |:
Zfish   549 TDCAQFPEEGQANSSCLLPDPDVNECSPSHFKCRSGRCVLSSKRCDGHTDCDDDSDEEMCGCLER 613

  Fly   175 DLYGLPG-----------QGIPGGLGGKLPMDCS--------GLAKSH---------LYVRLPRS 211
            .|:..||           .|.|         |||        ....||         ::..|...
Zfish   614 GLWECPGDKSCIPHSMICDGFP---------DCSQHEDENNCSACSSHELECNNHECVHRALWCD 669

  Fly   212 GR-----------CAPLC-EADILFTPA--EKHL-AEIWVSTWAYAALGLALVATVCLLASDGSR 261
            ||           |..|. |..:|...|  |.|: |:.|....:         :..|.....||.
Zfish   670 GRRHCSDSSDEWNCVSLSDEGSLLVYKAGLEYHVCADGWSPNHS---------SVTCTQMGLGSP 725

  Fly   262 LASAKWSRLL--SPLI----WCHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGL---SN 317
            |::   ..:|  ||::    |.|                     .||....|::|.:.||   ..
Zfish   726 LST---DAMLDVSPVVRRKRWLH---------------------VDPDWSPENMLPLQGLLEKRG 766

  Fly   318 ASC-----ASVFLMRYYFGMAACAWWAVLCLG----------WHRDIRRHSPDSKGHV---VIPS 364
            .||     .|:...|...|....|......||          |...::   .|..||:   |:..
Zfish   767 QSCQSYKKISLQCTRDECGRRPAARLVKRILGGRTSRPGRWPWQCSLQ---SDPSGHICGCVLIG 828

  Fly   365 N---------FGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQT----SAVIVARF----VDA 412
            |         |.|    |.||...:..|..||    :....|..||    |.::.:|:    ||.
Zfish   829 NKWALTVAHCFEG----RESADVWKVVLGINN----LDHPSPYMQTRRVKSIIVHSRYNRAVVDY 885

  Fly   413 D--------ELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALS 469
            |        |:|...:|             .|| |....|.:.....|   |.........|.:.
Zfish   886 DISVLELESEVLVTSYV-------------RPV-CLPRHGQLPKPDKY---CHITGWGHVGNRMP 933

  Fly   470 VQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTPL--------WP- 525
            .:.|..::...|.|....:..:..:...||...  ||...||..:  ||:..||        |.
Zfish   934 FKLQEGEVRIISVSQCQSYFDMKTITSRMLCAG--YEAGTIDSCM--GDSGGPLVCEEDDGHWSL 994

  Fly   526 FLLRAFMELMLGICCFAWVLGPSI 549
            :.|.::     |..||:.||||.:
Zfish   995 YGLTSW-----GSVCFSKVLGPGV 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	44/127 (35%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	79/384 (21%)
corin	XP_009295418.2	CRD_corin_1	136..258	CDD:143554
		LDLa	268..299	CDD:238060
		LDLa	301..335	CDD:238060
		Ldl_recept_a	342..372	CDD:278486
		LDLa	382..409	CDD:238060
		CRD_corin_2	448..569	CDD:143579	44/121 (36%)
		LDLa	574..608	CDD:238060	1/33 (3%)
		LDLa	<620..646	CDD:238060	6/34 (18%)
		LDLa	649..683	CDD:238060	5/33 (15%)
		SR	689..>728	CDD:214555	11/47 (23%)
		Tryp_SPc	796..1027	CDD:238113	56/255 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910