DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and fzd8

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001090860.2	Gene:	fzd8 / 100038274	XenbaseID:	XB-GENE-480800	Length:	580	Species:	Xenopus tropicalis

Alignment Length:	651	Identity:	170/651 - (26%)
Similarity:	275/651 - (42%)	Gaps:	130/651 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVG 69
            |:..||:.:        |...|:..|::...|         |:.|.:.:|:.||||.|.|||...
Frog     3 CLYLLLLAV--------SWLQGSQCAAAKELS---------CQEITVPLCKDIGYNYTYMPNQFN 50

  Fly    70 NEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTP--KAPVHAIGPCRSLCESVRIRCHP 132
            ::.|.:....:..|.||:...||..||.|||:.|.|:|..  |.|   :.||||:||..|..|.|
Frog    51 HDTQDEAGMEVHQFWPLVVIHCSPDLKFFLCSMYTPICLEDYKKP---LPPCRSVCERARAGCAP 112

  Fly   133 VLQGFGFPWPPALDCDKFPRENNHETMCME---------------------------GPGELHQP 170
            :::.:||.||..:.||:.|.:.|.:|:||:                           |...:..|
Frog   113 LMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYYNRTEQTTAAPSHPEPPKPPARSAPKGRTRVEPP 177

  Fly   171 QQEQDLYGLPGQGIPG---GLGGKLPMDCSGLAKSHLYVRLPRSGR---CAPLCEADILFTPAEK 229
            :        |....||   |...:.||......:..||.|: |:|:   ||..|. :..|:|.|:
Frog   178 R--------PRPRAPGCEPGCQCRAPMVPVTNERHPLYNRV-RTGQIPNCAMPCH-NPYFSPEER 232

  Fly   230 HLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRFMV 291
            ...|.|:..|:..... :..|||.....|..|....:     .|:|:   |:.:|:.|:.||.:.
Frog   233 TFTEFWIGLWSVLCFA-STFATVSTFLIDMERFKYPE-----RPIIFLSACYLLVSAGYLVRLIA 291

  Fly   292 GRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDS 356
            |....||... :...|.::..:....|.|..|||:.|:||||:..||.:|.|.|
Frog   292 GHEKVACSRG-ELDLEHIIHYETTGPALCTLVFLLIYFFGMASSIWWVILSLTW----------- 344

  Fly   357 KGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFV 421
                     |..:..|..:...|    ..:.:....||.:|:.::.||:....||.|.:.|.|||
Frog   345 ---------FLAAGMKWGNEAIA----GYSQYFHLAAWLVPSIKSIAVLALSSVDGDPVAGICFV 396

  Fly   422 GNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIG 486
            |||:...|:..|..|:..|...|||.|::|::...|.:.:::.....:  .:|::|...    ||
Frog   397 GNQNLDNLRGFVLAPLVIYLFIGSMFLLAGFVSLFRIRSVIKQGGTKT--DKLEKLMIR----IG 455

  Fly   487 IFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNT-------PLWP----FLLRAFMELMLGICC 540
            ||..:|.:...:::....||..|...|..:.:.|:       |..|    |:|:.||.|::||..
Frog   456 IFSVLYTVPATIVVACFFYEQHNRQGWEVAHNCNSCQPEVAQPRRPDYAVFMLKYFMCLVVGITS 520

  Fly   541 FAWVLGPSISTLYKRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASV 605
            ..|:.             :||.::...| ..|....|..::.||..:..||.:::.|...|..|.
Frog   521 GVWIW-------------SGKTLESWRA-FCTRCCWGSKATGGSMYSDVSTGLTWRSGTGSSVSY 571

  Fly   606 P 606
            |
Frog   572 P 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	48/154 (31%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	86/334 (26%)
fzd8	NP_001090860.2	CRD_FZ8	23..147	CDD:143570	48/135 (36%)
		7tmF_FZD8	225..538	CDD:320378	90/363 (25%)
		TM helix 1	234..259	CDD:320378	6/25 (24%)
		TM helix 2	268..289	CDD:320378	6/25 (24%)
		TM helix 3	320..342	CDD:320378	11/21 (52%)
		TM helix 4	363..379	CDD:320378	3/15 (20%)
		TM helix 5	401..424	CDD:320378	7/22 (32%)
		TM helix 6	452..477	CDD:320378	7/28 (25%)
		TM helix 7	499..524	CDD:320378	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010