DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fz4 and fzd3

DIOPT Version :9

Sequence 1:	NP_511068.2	Gene:	fz4 / 31659	FlyBaseID:	FBgn0027342	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001123382.1	Gene:	fzd3 / 100038082	XenbaseID:	XB-GENE-484322	Length:	664	Species:	Xenopus tropicalis

Alignment Length:	718	Identity:	179/718 - (24%)
Similarity:	279/718 - (38%)	Gaps:	161/718 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPK 110
            ||.|.:.||:.:.||.|.||||:.:..|......::.|.|::..:||...:.||||.|.|:|...
Frog    27 CEPITLRMCQDLPYNSTFMPNLLNHYDQQTAALAMEPFHPMVNLECSRDFRPFLCALYAPVCMEY 91

  Fly   111 APVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPR-ENNHETM---CMEGPGELHQPQ 171
            ..|..  |||.||:.....|..:::.||.|||..::|.:||. :..:..|   .:.|......|.
Frog    92 GRVTL--PCRKLCQRAYNECFKLMEMFGVPWPEEMECSRFPDCDEPYPRMVDISLSGDVTEETPL 154

  Fly   172 QEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLCEADILFTPAEKHLAEIWV 236
            ..|..||.   ..|..|  |:..|   |..|.|.||     .|:|.| ..:.|...|...|..::
Frog   155 AVQRDYGF---WCPREL--KIDPD---LGYSFLGVR-----DCSPPC-PHMYFRREELSFARYFI 205

  Fly   237 STWAYAALGLALVATVCLLAS---------DGSRLASAKWSRLLSPLIW---CHNMVTLGWAVRF 289
                      .:::.|||.|:         |.:|....:     .|:|:   |:.||:|.:.:.|
Frog   206 ----------GVISIVCLSATLFTFLTFLIDVTRFRYPE-----RPIIFYAVCYMMVSLIFFIGF 255

  Fly   290 MVGRTGTAC-GTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHS 353
            :: ....|| |.:|.....:.:| .|..|.:|..:|::.|:|.||...||.:|.:.|..
Frog   256 LL-EDKVACNGANPSQYKAATVT-QGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFL------ 312

  Fly   354 PDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGA 418
                  ..:|.  .||.|....|......          |||:|...|..::....::.|.:.|.
Frog   313 ------AAVPK--WGSEAIEKKALLFHAS----------AWGIPGTLTIILLAMNKIEGDNISGV 359

  Fly   419 CFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTK-EI-LRNSNALSVQQQLQQLSAHS 481
            ||||....:||:..|..|:....:.|...|::|.:...|.: || |...|    |.:|.:....
Frog   360 CFVGLYDVQALRYFVLAPLCLDVVVGVSLLLAGIISLNRVRIEIPLEKEN----QDKLVKFMIR- 419

  Fly   482 SSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGS-----------------GDTNTP-LWPFLL 528
               ||:|..:|.:...:::....||.|...||..:                 ..|:.| |..||:
Frog   420 ---IGVFSILYLVPLLVVIGCYFYEQAYRGVWETTWVQERCKEYHIPCPYKVTQTSRPDLILFLM 481

  Fly   529 RAFMELMLGI----------CCFAWV---------LGPSISTLYKRQV----------------- 557
            :..|.|::||          .||.|.         .|.:.|    |||
Frog   482 KYLMALVVGIPSVFWVGSKKTCFEWASFFHGRKKKAGVNES----RQVLQEPDFAQSLLRDPNTP 542

  Fly   558 ----SNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYH-SVRTSMASVPLPPSPYKLKTS 617
                |.|...:.||..|::..|......|....:.:|.|.||| |:..|......|.|...::..
Frog   543 IVRKSRGTSTQGTSTHASSTQLAMLDDQRSKAGSVHSKVSSYHGSLHRSRDGRYTPCSYRGMEER 607

  Fly   618 PGTGSISLNQMSNYSLGRSVHHQQRHSPHHHHHQQQQHHQFHPHHN---HQHHSTSSHRLYYPPG 679
            ...||:|  .::::|         |||..|..::|.:........|   |..|.||.:|:....|
Frog   608 LPHGSLS--HLTDHS---------RHSSTHRLNEQSRQGSIRDLSNPLAHISHGTSMNRVIEEDG 661

  Fly   680 SYA 682
            :.|
Frog   662 ASA 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fz4	NP_511068.2	CRD_FZ4	43..169	CDD:143557	41/126 (33%)
fz4	NP_511068.2	7tm_4	223..544	CDD:304433	83/363 (23%)
fzd3	NP_001123382.1	CRD_FZ3	23..149	CDD:143558	41/123 (33%)
		7tmF_FZD3	191..511	CDD:320161	84/368 (23%)
		TM helix 1	200..225	CDD:320161	5/34 (15%)
		TM helix 2	234..255	CDD:320161	6/25 (24%)
		TM helix 3	286..312	CDD:320161	9/25 (36%)
		TM helix 4	329..351	CDD:320161	5/31 (16%)
		TM helix 5	365..390	CDD:320161	5/24 (21%)
		TM helix 6	418..443	CDD:320161	6/28 (21%)
		TM helix 7	472..497	CDD:320161	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910