DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4617 and hmgxb4

DIOPT Version :9

Sequence 1:	NP_001259308.1	Gene:	CG4617 / 31657	FlyBaseID:	FBgn0029936	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001025555.1	Gene:	hmgxb4 / 594948	XenbaseID:	XB-GENE-951781	Length:	554	Species:	Xenopus tropicalis

Alignment Length:	404	Identity:	117/404 - (28%)
Similarity:	178/404 - (44%)	Gaps:	131/404 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RSGRVRKKSSKLLDFESPDEIEKRTRRHSGARQPARYSGRGRPSNALRDLDLDQEMLVDDGIISD 84
            :|.:.:||..|..| |...:..|..|.|.|..:|.:.:....||
Frog   277 KSKKSKKKKDKHKD-EKHRKHSKSKREHEGEERPTQIASPVLPS--------------------- 319

  Fly    85 SEEFHPDTTATVVAILNSDDELDNLVQDIVDGVQAEATSQESSVRQSL--YMREKSNKRQVLKDG 147
                .|..|||.                        .||..|...|:|  :..|:.:|::..:|
Frog   320 ----PPPPTATT------------------------PTSPPSVPPQALITHAEEQLDKKKKKED- 355

  Fly   148 KVVSAKVQRKDKGKQRYTAYSLWAKEARQKDLQD---LDFTSATRRLSELWANVSNRDKNTWRRK 209
                   ..|.| |:..:||.:::||.|...:.:   :||...:::|:|:|..:..:||..|::|
Frog   356 -------PEKPK-KKNMSAYQVFSKEYRGSIIAEHPGIDFGELSKKLAEVWKQLPEKDKLAWKQK 412

  Fly   210 AKIEASRAKTRDKTAANGATQPASNGSTALADATQHETIFQNRATTSRTRKLAADRQQSSIEAAA 274
            |:.                              .||:   ||:|..:..:     |:.||.|
Frog   413 AQY------------------------------LQHK---QNKAEATTVK-----RKSSSSE--- 436

  Fly   275 AAAAAAATGTNTQRRSISTRSARSQVSKSATKQAQVHTDADVSGRTGGQLKQEEVQKTSIEVIDA 339
              :||.:.|:::...|.:.:|..|.||.| |..|:|                     ...|.||.
Frog   437 --SAARSKGSSSGLPSPNKKSPTSVVSFS-TSPAKV---------------------PDTEPIDV 477

  Fly   340 AAHLKLLGESLTVIGERLKKHNGYVALSGSLSVLLDSLLCAMGPLLCMTTQIPGMENNVQLSKNL 404
            ||||:||||||::||.||::..|.||:||||||||||:|||:|||:|:|:.:|.:  |....:.|
Frog   478 AAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSILCALGPLVCLTSHVPQL--NACPKQIL 540

  Fly   405 ADTLDNIAYVMPGL 418
            ::||||||||||||
Frog   541 SNTLDNIAYVMPGL 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4617	NP_001259308.1	HMG-box	165..218	CDD:238037	15/55 (27%)
hmgxb4	NP_001025555.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..368		29/149 (19%)
		DUF4171	107..226	CDD:316308
		HMG-box	364..423	CDD:238037	19/91 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..468		18/63 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008243
OrthoInspector	1	1.000	-	-		oto104949
Panther	1	1.100	-	-	LDO	PTHR46584
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5833
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.040