DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4617 and hmgxb4a

DIOPT Version :9

Sequence 1:	NP_001259308.1	Gene:	CG4617 / 31657	FlyBaseID:	FBgn0029936	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_005163967.1	Gene:	hmgxb4a / 559742	ZFINID:	ZDB-GENE-070912-675	Length:	632	Species:	Danio rerio

Alignment Length:	427	Identity:	121/427 - (28%)
Similarity:	184/427 - (43%)	Gaps:	122/427 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESPTSHLVAKDFQVTGVSRSGRVRKKSSKLLDFESPDEIEK--RTRRHSGARQPARYSGRGRPSN 64
            |.....||..| ..|.:|:..:..|||.|..|.|...:.||  |.::||......:.|.:|
Zfish   318 ELEAGELVIDD-SYTRLSKKKKKSKKSKKKKDKERDRDREKGSREKKHSKGGSGGKKSSQG---- 377

  Fly    65 ALRDLDLDQEMLVDDGIISDSEEFHPDTTATVVAILNSDDELDNLVQDIVDGVQAEATSQESSVR 129
                               |....|..|.       :|.:...:      .|:...|....|...
Zfish   378 -------------------DQPRSHSHTH-------SSSNHSSS------GGMYPMAPPTSSHQH 410

  Fly   130 QSL-YMREKSNKRQVLKDGKVVSAKVQRKDKGKQR-YTAYSLWAKEAR---QKDLQDLDFTSATR 189
            ||: .:.||..|::..:..|      ..|||.|:: .|||.::.||.|   ..:...|.|...::
Zfish   411 QSIELIGEKKKKKEEKERDK------HDKDKPKKKNMTAYQVFCKEYRVNINAEQPGLVFGELSK 469

  Fly   190 RLSELWANVSNRDKNTWRRKAKIEASRAKTRDKTAANGATQPASNGSTALADATQHETIFQNRAT 254
            :|:|:|..:..:||..||:||:.                              .||:   ||:|
Zfish   470 KLAEVWKQLPEKDKLVWRQKAQY------------------------------LQHK---QNKA- 500

  Fly   255 TSRTRKLAADRQQSSIEAAAAAAAAAATGTNTQRRSISTRSARSQVSKSATKQAQVHTDADVSGR 319
                            ||           ...:|::::|..::   ||.::|...:.:.....||
Zfish   501 ----------------EA-----------MTVKRKTLTTSDSK---SKGSSKAFSLGSGLAPQGR 535

  Fly   320 TGGQLKQEEVQKTSIEVIDAAAHLKLLGESLTVIGERLKKHNGYVALSGSLSVLLDSLLCAMGPL 384
            :...:.....:...::.|||||||:||||||::||.||::..|.||:||||||||||:|||:|||
Zfish   536 SSLGMSLSPARVPDVDPIDAAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSILCALGPL 600

  Fly   385 LCMTTQIP---GMENNVQLSKNLADTLDNIAYVMPGL 418
            .|:|.|:|   |...|:     |::|||||||:||||
Zfish   601 TCLTAQVPQLNGCPRNI-----LSNTLDNIAYIMPGL 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4617	NP_001259308.1	HMG-box	165..218	CDD:238037	17/55 (31%)
hmgxb4a	XP_005163967.1	DUF4171	121..262	CDD:290491
hmgxb4a	XP_005163967.1	HMG-box	441..500	CDD:238037	21/91 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008243
OrthoInspector	1	1.000	-	-		oto39145
orthoMCL	1	0.900	-	-		OOG6_109229
Panther	1	1.100	-	-	LDO	PTHR46584
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5833
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030