DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and HXT5

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_011964.1	Gene:	HXT5 / 856496	SGDID:	S000001138	Length:	592	Species:	Saccharomyces cerevisiae

Alignment Length:	545	Identity:	137/545 - (25%)
Similarity:	230/545 - (42%)	Gaps:	73/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PPAYKPTVVAKDTTKDSHAKEKPLGEGRLAVLRQELMVFLGNSGVLGSGMVVSMPAVTLNQLHDE 76
            ||..:...:.|:..|....|.|   ...|.|....|||..|       |.|......|::....:
Yeast    59 PPKDELEELQKEVDKQLEKKSK---SDLLFVSVCCLMVAFG-------GFVFGWDTGTISGFVRQ 113

  Fly    77 TQ------------PFWLNKDESSWFASIQNMACPLGGLLVSYFLDRIGRKHTILLTNLIGLIGW 129
            |.            ..:|:...:....||.|:.|.:||:::|...|..|||..::...:|..||.
Yeast   114 TDFIRRFGSTRANGTTYLSDVRTGLMVSIFNIGCAIGGIVLSKLGDMYGRKIGLMTVVVIYSIGI 178

  Fly   130 ILLVTSFMHSDRDMIYYQMLLGRCFGGIMIGMFVSPVGVYSAEISLPKIRGRLILGTSLGLASGI 194
            |:.:.|.   |:   :||..:||...|:.:|.......:..:|:|..::||.|:....|.:..||
Yeast   179 IIQIASI---DK---WYQYFIGRIISGLGVGGITVLAPMLISEVSPKQLRGTLVSCYQLMITFGI 237

  Fly   195 LLMYCLGYFIR---HNIQLIFGISCCYQLAATLLV---FPMPESPSWLLTRGKEERARKSLRYFR 253
            .|.||..:..:   :::|....:..|:..:..::|   | :||||.:|:..||.|.|::||
Yeast   238 FLGYCTNFGTKNYSNSVQWRVPLGLCFAWSIFMIVGMTF-VPESPRYLVEVGKIEEAKRSL---- 297

  Fly   254 GLPKKEVDYVPEFEAELAHMKELADASNTTAAGESLSQMIHRPEVYKPVLMMTTFFGFQQACGVV 318
            ....|..:..|....|:.:.:...:|.....:......:..:|::::..||.......||..|..
Yeast   298 ARANKTTEDSPLVTLEMENYQSSIEAERLAGSASWGELVTGKPQMFRRTLMGMMIQSLQQLTGDN 362

  Fly   319 VIIVYAVQIAQQAGVTIDPVLVAVMLGVARIITTLFMSGIFEKWGRKPSGIFSATGMGACMLLLA 383
            ....|...|.|..|:. |....|::|||...::|.|.....:::||:...::...||..|.::.|
Yeast   363 YFFYYGTTIFQAVGLE-DSFETAIVLGVVNFVSTFFSLYTVDRFGRRNCLLWGCVGMICCYVVYA 426

  Fly   384 ---------GGNWFPDTLGTLHWLPV-ACIVAHIVFSTMGMLTLPFFMISEVFPQRARGSASGIA 438
                     .|...|.:.|..:.:.| ||.......:|..  .:.:.:|||.:|.|.||.|..||
Yeast   427 SVGVTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFATTWA--PVAYVLISESYPLRVRGKAMSIA 489

  Fly   439 IFFGMILAFIMLKIYPNMEAALGTANLFAFYAGISFL-----AAAFIGVFVPETRGRTLEELEER 498
            .....|..|::....|.:.:|:.      ||.|..|:     |..::..|||||:|.||||:.|.
Yeast   490 SACNWIWGFLISFFTPFITSAIN------FYYGYVFMGCMVFAYFYVFFFVPETKGLTLEEVNEM 548

  Fly   499 -------WQTGKF---SRRLTIVNL 513
                   |::.|:   |||.|..:|
Yeast   549 YEENVLPWKSTKWIPPSRRTTDYDL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	107/461 (23%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	114/460 (25%)
HXT5	NP_011964.1	Sugar_tr	89..549	CDD:395036	122/486 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740