DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and HXT4

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_011960.2	Gene:	HXT4 / 856492	SGDID:	S000001134	Length:	576	Species:	Saccharomyces cerevisiae

Alignment Length:	534	Identity:	136/534 - (25%)
Similarity:	228/534 - (42%)	Gaps:	93/534 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LMVFLG------NSGVLGSGMVVSMPAVTLNQL--HDETQPFWLNKDESSWFASIQNMACPLGGL 103
            |||..|      ::|.: ||.|.....:....:  ||.|  ::|:|..:....||.|:.|.:||:
Yeast    76 LMVAFGGFVFGWDTGTI-SGFVAQTDFIRRFGMKHHDGT--YYLSKVRTGLIVSIFNIGCAIGGI 137

  Fly   104 LVSYFLDRIGRKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQMLLGRCFGGIMIG--MFVSPV 166
            :::...|..|||..:::..:|.:||.|:.:.|...      :||..:||...|:.:|  ..:||:
Yeast   138 ILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINK------WYQYFIGRIISGLGVGGIAVLSPM 196

  Fly   167 GVYSAEISLPKIRGRLILGTSLGLASGILLMYCLGY-------FIRHNIQLIFGIS-CCYQLAAT 223
            .:  :|:|...|||.|:....|.:..||.|.||..|       .::..:.|..|.: ..:.:...
Yeast   197 LI--SEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVPLGLGFAWALFMIGGM 259

  Fly   224 LLVFPMPESPSWLLTRGKEERARKSLRYFRGLPKKEVDYVPEFEAELAHMKELADA---SNTTAA 285
            ..|   ||||.:|:..||.|.|::|:    .|..|.....|...||:..::...:|   :...:.
Yeast   260 TFV---PESPRYLVEVGKIEEAKRSI----ALSNKVSADDPAVMAEVEVVQATVEAEKLAGNASW 317

  Fly   286 GESLSQMIHRPEVYKPVLMMTTFFGFQQACGVVVIIVYAVQIAQQAGVTIDPVLVAVMLGVARII 350
            ||..|.   :.:|::.::|.......||..|......|...:....|:. |....:::||:....
Yeast   318 GEIFST---KTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLE-DSFETSIVLGIVNFA 378

  Fly   351 TTLFMSGIF--EKWGRKPSGIFSATGMGACMLLLAGGNWFPDTLGTLHWLPVA-----------C 402
            :|..  |||  |::||:...::.|..|.|||::.|       ::|.....|..           |
Yeast   379 STFV--GIFLVERYGRRRCLLWGAASMTACMVVFA-------SVGVTRLWPNGKKNGSSKGAGNC 434

  Fly   403 IVAHIVFSTMGMLT----LPFFMISEVFPQRARGSASGIAIFFGMILAFIMLKIYPNMEAALGTA 463
            ::....|......|    :||.:.||.||.|.:.....||.....|..|::....|.:..|:.
Yeast   435 MIVFTCFYLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPFISGAID-- 497

  Fly   464 NLFAFYAGISFLAAA-----FIGVFVPETRGRTLEELEERWQTGKF----------SRRLTIVNL 513
                ||.|..|:...     ::..|||||:|.||||:...|:.|..          ::|.|..|.
Yeast   498 ----FYYGYVFMGCLVFSYFYVFFFVPETKGLTLEEVNTLWEEGVLPWKSPSWVPPNKRGTDYNA 558

  Fly   514 KDVELH--EVFLKK 525
            .|: :|  :.|.||
Yeast   559 DDL-MHDDQPFYKK 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	112/465 (24%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	117/464 (25%)
HXT4	NP_011960.2	Sugar_tr	74..534	CDD:395036	126/494 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342958
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740