DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and HXT8

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_012321.1	Gene:	HXT8 / 853216	SGDID:	S000003750	Length:	569	Species:	Saccharomyces cerevisiae

Alignment Length:	528	Identity:	126/528 - (23%)
Similarity:	217/528 - (41%)	Gaps:	69/528 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GQQEEQLVPPPAYKPTVVAKDTTKDSHAKEKPLGEGRLAVLRQELMVFLG-----NSGVLGSGMV 62
            |::.|::|.|                   |||........:....|.|.|     ::|.: ||.|
Yeast    47 GEEAEEVVVP-------------------EKPASAYATVSIMCLCMAFGGFMSGWDTGTI-SGFV 91

  Fly    63 VSMPAVTL--NQLHDETQPFWLNKDESSWFASIQNMACPLGGLLVSYFLDRIGRKHTILLTNLIG 125
            .....:..  |..|.: ..::|:...:....||.|:...:|.|.:|...|..||...:::..::.
Yeast    92 NQTDFLRRFGNYSHSK-NTYYLSNVRTGLIVSIFNVGSAIGCLFLSKLGDIYGRCMGLIIVIVVY 155

  Fly   126 LIGWILLVTSFMHSDRDMIYYQMLLGRCFGGIMIGMFVSPVGVYSAEISLPKIRGRLILGTSLGL 190
            ::|.::.:.|.   |:   :||..:||...||..|.......:..:|.:...|||.|:....|.:
Yeast   156 MVGIVIQIASI---DK---WYQYFIGRIIAGIGAGSISVLAPMLISETAPKHIRGTLLACWQLMV 214

  Fly   191 ASGILLMYCLGYFIR---HNIQLIFGISCCYQLAATL---LVFPMPESPSWLLTRGKEERARKSL 249
            ...|.|.||..|..:   :::|....:..|:..|..:   :.| :||||.:|:..||.|:|:.|.
Yeast   215 TFAIFLGYCTNYGTKTYSNSVQWRVPLGLCFAWAIIMIGGMTF-VPESPRFLVQVGKIEQAKASF 278

  Fly   250 RYFRGLPKKEVDYVPEFEAELAHMKELADASNTTAAGESLSQMIHRPEVYKPVLMMTTFFGFQQA 314
            .....|...:...|.|.:..:|.: |..:|..|.:..|..|:   :.:|::.:.|.......||.
Yeast   279 AKSNKLSVDDPAVVAEIDLLVAGV-EAEEAMGTASWKELFSR---KTKVFQRLTMTVMINSLQQL 339

  Fly   315 CGVVVIIVYAVQIAQQAGVTIDPVLVAVMLGVARIITTLFMSGIFEKWGRKPSGIFSATGMGACM 379
            .|......|...|.:..|:. |....:::||:....:..|.....:|.||:...:..|..|.|||
Yeast   340 TGDNYFFYYGTTIFKSVGMN-DSFETSIVLGIVNFASCFFSLYSVDKLGRRRCLLLGAATMTACM 403

  Fly   380 LLLA---------GGNWFPDTLGTLHWLPV-ACIVAHIVFSTMGMLTLPFFMISEVFPQRARGSA 434
            ::.|         .|...|.:.|..:...| .|........|.|.:.  :.:|||.||.|.|...
Yeast   404 VIYASVGVTRLYPNGKSEPSSKGAGNCTIVFTCFYIFCFSCTWGPVC--YVIISETFPLRVRSKC 466

  Fly   435 SGIAIFFGMILAFIMLKIYPNMEAALGTANLFAFYAGISFLAAA-----FIGVFVPETRGRTLEE 494
            ..:|....::..|::....|.:.:|:.      ||.|..|:...     ::..|||||:|.||||
Yeast   467 MSVATAANLLWGFLIGFFTPFITSAIN------FYYGYVFMGCLAFSYFYVFFFVPETKGLTLEE 525

  Fly   495 LEERWQTG 502
            ::|.|..|
Yeast   526 VDEMWMDG 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	103/451 (23%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	108/450 (24%)
HXT8	NP_012321.1	Sugar_tr	69..530	CDD:395036	117/482 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740