DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_445946.2	Gene:	Slc2a8 / 85256	RGDID:	620611	Length:	478	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	135/478 - (28%)
Similarity:	219/478 - (45%)	Gaps:	53/478 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LMVFLGNSGVLGSGMVVSMPAVTLNQLHDETQP-FWLNKDESSWFASIQNMACPLGGLLVSYFLD 110
            |..|....|.|..|..:...:..:..|.....| ..|....:|||.::..:....||:|..:.||
  Rat    28 LATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDTAASWFGAVVTLGAAAGGVLGGWLLD 92

  Fly   111 RIGRKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQMLLGRCFGGIMIGM--FVSPVGVYSAEI 173
            |.|||.::||..:..:.|:.::..:     ||:  :.:|.||...|:..|:  .|:|  ||.:||
  Rat    93 RAGRKLSLLLCTVPFVTGFAVITAA-----RDV--WMLLGGRLLTGLACGVASLVAP--VYISEI 148

  Fly   174 SLPKIRGRLILGTSLGLASGILLMYCLGYFIRHNIQLIFGISCCYQLAATLLVFPMPESPSWLLT 238
            :.|.:||.|.....|.:.:||||.|..|:.:......:.|  |.......||:..|||:|.:|||
  Rat   149 AYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLG--CVPPTLMLLLMCYMPETPRFLLT 211

  Fly   239 RGKEERARKSLRYFRGLPKKEVDYVPEFEAELAHMKELADASNTTAAGESLSQMIHRPEVYKPVL 303
            :.:.:.|..:||:..|  .:|....|...||  |.            |..|: |:.||.|:||::
  Rat   212 QHQYQEAMAALRFLWG--SEEGWEEPPVGAE--HQ------------GFQLA-MLRRPGVHKPLI 259

  Fly   304 MMTTFFGFQQACGVVVIIVYAVQIAQQAGVTIDPVLVAVMLGVARIITTLFMSGIFEKWGRK--- 365
            :......|||..||..|:.||..|.::|... |..|.:|.:|:.:::.|...:.|.::.|||
  Rat   260 IGICLMVFQQLSGVNAIMFYANTIFEEAKFK-DSSLASVTVGIIQVLFTAVAALIMDRAGRKLLL 323

  Fly   366 -PSG---IFSATGMGACMLLLAGGNWFPDTLGTL----------H----WLPVACIVAHIVFSTM 412
             .||   :||.:..|....|...|......:|.|          |    ||.|..:...|....:
  Rat   324 ALSGVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAGFAV 388

  Fly   413 GMLTLPFFMISEVFPQRARGSASGIAIFFGMILAFIMLKIYPNMEAALGTANLFAFYAGISFLAA 477
            |...:|:.::||:||...:|.|:|:.:.....:||::.|.:.::...|.....|...|....|:.
  Rat   389 GWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCILSV 453

  Fly   478 AFIGVFVPETRGRTLEELEERWQ 500
            .|...|||||:|||||::...::
  Rat   454 LFTLTFVPETKGRTLEQITAHFE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	123/452 (27%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	130/451 (29%)
Slc2a8	NP_445946.2	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:10671487	12..13
		MFS	27..470	CDD:421695	134/470 (29%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337830
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860