DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and ITR1

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_010785.1	Gene:	ITR1 / 852108	SGDID:	S000002905	Length:	584	Species:	Saccharomyces cerevisiae

Alignment Length:	471	Identity:	115/471 - (24%)
Similarity:	204/471 - (43%)	Gaps:	70/471 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 IQNMACPLGGLLVSYF----LDRIGRKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQMLLGRC 153
            |...|..||.|:.|.|    .|..|||..::.:||:.:||.||.|::  |:     ::||.:||.
Yeast   130 IVTAATSLGALITSIFAGTAADIFGRKRCLMGSNLMFVIGAILQVSA--HT-----FWQMAVGRL 187

  Fly   154 F--GGIMIGMFVSPVGVYSAEISLPKIRGRLILGTSLGLASGILLMYCLG---YFIRHNIQLIFG 213
            .  .|:.||..::|  ::.:||:...|||||.:..||.|..|.|:.|..|   .::.:..:::.|
Yeast   188 IMGFGVGIGSLIAP--LFISEIAPKMIRGRLTVINSLWLTGGQLVAYGCGAGLNYVNNGWRILVG 250

  Fly   214 ISCCYQLAATLLVFP----MPESPSWLLTRGKEERARKSLRYFRGLPKKEVDYVPEFEAELAHMK 274
            :|    |..|.:.|.    :|::|.:.:.:|...||.:.|:  |.......:.:.....||..:.
Yeast   251 LS----LIPTAVQFTCLCFLPDTPRYYVMKGDLARATEVLK--RSYTDTSEEIIERKVEELVTLN 309

  Fly   275 ELADASNTTAAGESLSQMIHR-PEVYKPVLMMTTFFGFQQACGVVVIIVYAVQIAQQAGVTIDPV 338
            :.....|......:..:.:|. |...:.:::.......||..|...::.::..|.:..|.. :..
Yeast   310 QSIPGKNVPEKVWNTIKELHTVPSNLRALIIGCGLQAIQQFTGWNSLMYFSGTIFETVGFK-NSS 373

  Fly   339 LVAVMLGVARIITTLFMSGIFEKWGRKPSGIFSATGM-------------------GACMLLLAG 384
            .|::::.....|.||......:|.||:...:....||                   ||..::::.
Yeast   374 AVSIIVSGTNFIFTLVAFFSIDKIGRRTILLIGLPGMTMALVVCSIAFHFLGIKFDGAVAVVVSS 438

  Fly   385 G--NWFPDTLGTLHWLPVACIVAHIVFS---TMGMLTLPFFMISEVFPQRARGSASGIAIFFGMI 444
            |  :|           .:..||..|||:   .:|:.|:| :..||:|||..||..:..|......
Yeast   439 GFSSW-----------GIVIIVFIIVFAAFYALGIGTVP-WQQSELFPQNVRGIGTSYATATNWA 491

  Fly   445 LAFIMLKIYPNMEAALGTANLFAFYAGISFLAAAFIGVFVPETRGRTLEELEERWQTG---KFSR 506
            .:.::...:..|...:..|..|||:||:|.|:..|.....||..|..|||::...:.|   |.|:
Yeast   492 GSLVIASTFLTMLQNITPAGTFAFFAGLSCLSTIFCYFCYPELSGLELEEVQTILKDGFNIKASK 556

  Fly   507 RLTIVNLKDV-ELHEV 521
            .|.....:.| .:||:
Yeast   557 ALAKKRKQQVARVHEL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	102/428 (24%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	107/439 (24%)
ITR1	NP_010785.1	MFS_HMIT_like	92..533	CDD:340918	102/430 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342434
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X729
TreeFam	0	0.000	Not matched by this tool.
	4	3.740