DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and CIN10

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_010675.3	Gene:	CIN10 / 851995	SGDID:	S000002795	Length:	555	Species:	Saccharomyces cerevisiae

Alignment Length:	554	Identity:	114/554 - (20%)
Similarity:	213/554 - (38%)	Gaps:	122/554 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 MVFLG----------NSGVLGSGMVVS-----MPAVTLNQLHDETQPFWLNKDESSWFASIQNMA 97
            ::|:|          ::||: ||:::|     :..|.|..:..|.  ...:....|:|.||  :|
Yeast    41 LIFVGATIGGLLFGYDTGVI-SGVLLSLKPEDLSLVVLTDVQKEL--ITSSTSVGSFFGSI--LA 100

  Fly    98 CPLGGLLVSYFLDRIGRKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQMLLGRCFGGIMIGMF 162
            .||.        ||.||:.|:.:...|     .:|....|...|.:.:  ::.||...||.:|:.
Yeast   101 FPLA--------DRYGRRITLAICCSI-----FILAAIGMAIARTLTF--LICGRLLVGIAVGVS 150

  Fly   163 VSPVGVYSAEISLPKIRGRLILGTSLGLASGILLMYCLGYFIR---HNIQLIFGISCCYQLAATL 224
            ...|.::.:|||..:|||.::....:.:..|.|:.|.:...::   ::.:.:|.:|....:....
Yeast   151 AQCVPLFLSEISPSRIRGFMLTLNIIAITGGQLVSYVIASLMKEIDNSWRYLFALSAIPAILFLS 215

  Fly   225 LVFPMPESPSWLLTRGKEERARKSLRYFRGLPKKEVDYV----PEFEAELAHMKELADA------ 279
            ::..:||||.|.:::|.....|.|||..  .|.....:|    .:...||..::...||
Yeast   216 ILDFIPESPRWSISKGDILYTRDSLRML--YPTASTYHVNSKIKQLIIELDKLRLYEDASEPLLV 278

  Fly   280 --------------------------SNTTAAGESLS----------------------QMIHR- 295
                                      |||.....::|                      :..||
Yeast   279 QSQSVIRYMDSSTSGTLSPPNIKRLSSNTERTSNTMSSSSAYLSALRGPAPNGALASNKKKRHRM 343

  Fly   296 -PEVYKPVLMMTTFFGFQQACGVVVIIVYAVQIAQQAGVTIDPVLVAVMLGVARIITTLFMSGIF 359
             |...:.:::......|||..|....:.||..|..:..:. :|:|..:::.....|.|.|.....
Yeast   344 EPRTIRALIVGCMLMFFQQITGFNAFMYYAAIIFSKFNIK-NPLLPPILIASTNFIFTFFAMYTM 407

  Fly   360 EKWGRKPSGIFSATGMGACMLLLAGGNWFPDTLGTLHWLPVACIVAHIVFSTMGMLTLPFFMISE 424
            :..||:...:.:...|...:||.:.| :..|.:..|    :..:|.::......|.::|:..: |
Yeast   408 DSLGRRAILLRTILIMTVGLLLCSVG-FGHDQVNLL----LISVVIYVAAYASAMGSVPWTCV-E 466

  Fly   425 VFPQRARG-SASGIAIFFGMILAFIMLKIYPNMEAALGTANLFAFYAGISFLAAAFIGVFVPETR 488
            ..|...|. .||.||....:..||:.: .|.:....:|..|....:|..:..|..|:..:.||.:
Yeast   467 FLPLNRRSFGASCIACTNWLTNAFVSM-TYLSTINTIGDENTMLIFAFFTVCAWFFVYFWYPEVK 530

  Fly   489 GRTLEELEERWQTGKFSRRLTIVNLKDVELHEVF 522
            |.:|||:...:..|             :::|.||
Yeast   531 GLSLEEVGRVFDNG-------------IDVHYVF 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	102/497 (21%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	102/491 (21%)
CIN10	NP_010675.3	MFS_HMIT_like	45..528	CDD:340918	103/512 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342424
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740