DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and MPH2

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_010034.1	Gene:	MPH2 / 851350	SGDID:	S000002406	Length:	609	Species:	Saccharomyces cerevisiae

Alignment Length:	541	Identity:	113/541 - (20%)
Similarity:	218/541 - (40%)	Gaps:	98/541 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DTTKDSHAKEKPLGEGRL---------------AVLRQELMVFLG-NSGVLGSGMVVSMPAVTLN 71
            |.|:|  |||....|..:               ::|....::..| ::.:||:...:.:......
Yeast    70 DATED--AKEADESERGMPLATALNTYPKAAAWSLLVSTTLIMEGYDTAILGAFYALPIFQRKFG 132

  Fly    72 QLHDETQPFWLNKDESSWFASIQNMACPLGGLLVSYFL-----DRIGRKHTILLTNLIGLIGWIL 131
            ..:|:|..:.::   :||  .|....|.:.|.:|...|     |.:|.::|:::.        :.
Yeast   133 SQNDKTGEWEIS---ASW--QIGLTLCYMAGEIVGLQLTGPSVDLVGNRYTLIIA--------LF 184

  Fly   132 LVTSFMHSDRDMIYY-----QMLLGRCFGGIMIGMFVSPVGVYSAEISLPKIRGRLILGTSLG-- 189
            .:.:|..    ::|:     .:.:|:...|:..|.|......|::||....:|..|...::|.
Yeast   185 FLAAFTF----ILYFCNSLGMIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWL 245

  Fly   190 ----LASGIL----LMYC---LGYFIRHNIQLIFGISCCYQLAATLLVFPMPESPSWLLTRGKEE 243
                .|:||:    ..|.   |||      :|.|.:.....:...|.:|..||||.||:.:|:.:
Yeast   246 FGQLFAAGIMKNSQKKYADSELGY------KLPFALQWILPVPLALGIFFAPESPWWLVKKGRFD 304

  Fly   244 RARKSLRYFRGL----PKKEVDYVPEFE-AELAHMKELADASNTTAAGESLSQMIHRPEVYKPVL 303
            .||:|||  |.|    |:||:....|.: .::...||....|...:..:.....|:|    :...
Yeast   305 EARRSLR--RTLSGKGPEKEILVTLEVDKIKVTIDKEKRLTSKEGSYSDCFEDKINR----RRTR 363

  Fly   304 MMTTFFGFQQACGVVVIIVYAVQIAQQAGVTIDPVLVAVMLGVARIITTLFMSGIFEKWGRKPSG 368
            :....:..|..|| .::|.|:....::|||:.:......::.....|...|:|.    |..|..|
Yeast   364 ITCLCWAGQATCG-SILIGYSTYFYEKAGVSTEMSFTFSIIQYCLGICATFLSW----WASKYFG 423

  Fly   369 IFSATGMG----ACMLLLAGGNWFPDTLGTLHWLPVACIVAHIVFSTMGMLTLPFFMISEVFPQR 429
            .:.....|    ..:..:.||.....|.|: .....:.::|...|..:|:..:.|.::||:...|
Yeast   424 RYDLYAFGLAFQTIVFFIIGGLGCSSTHGS-KMGSGSLLMAVAFFYNLGIAPVVFCLVSEMPSSR 487

  Fly   430 --------ARGSASGIAIFFGMILAFIMLKIYPNMEAALGTANLFAFYAGISFLAAAFIGVFVPE 486
                    ||.:.:.::|...:::.:.:.....|..|..|     .|:..:.|....:..|.:||
Yeast   488 LRTKTIILARNTYNVVSIICSVLILYQLNSKKWNWGAKSG-----FFWGVLCFCTLIWAVVDLPE 547

  Fly   487 TRGRTLEELEERWQTGKFSRR 507
            |.|:|..|:.|.::.|..:|:
Yeast   548 TAGKTFVEINELFKLGVSARK 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	95/468 (20%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	98/467 (21%)
MPH2	NP_010034.1	SP	72..556	CDD:273317	108/525 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342823
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830