DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and GAL2

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_013182.1	Gene:	GAL2 / 850770	SGDID:	S000004071	Length:	574	Species:	Saccharomyces cerevisiae

Alignment Length:	600	Identity:	137/600 - (22%)
Similarity:	231/600 - (38%)	Gaps:	129/600 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EEQLVPPPAYKPTV---VAKDTTKDSHAK-----------------------------EKPLGEG 38
            ||..:|..:.:|..   |....:||||..                             :||:.|.
Yeast     4 EENNMPVVSQQPQAGEDVISSLSKDSHLSAQSQKYSNDELKAGESGSEGSQSVPIEIPKKPMSEY 68

  Fly    39 RLAVLRQELMVFLG-----NSGVLGSGMVVSMPAVTLNQLHDETQPFWLNKDESSWFASIQNMAC 98
            ....|....:.|.|     ::|.: ||.||....:....:..:....:|:...:....:|.|:.|
Yeast    69 VTVSLLCLCVAFGGFMFGWDTGTI-SGFVVQTDFLRRFGMKHKDGTHYLSNVRTGLIVAIFNIGC 132

  Fly    99 PLGGLLVSYFLDRIGRKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQMLLGRCFGGIMIGMFV 163
            ..||:::|...|..|||..:.:...:.::|.|:.:.|...      :||..:||...|:.:|...
Yeast   133 AFGGIILSKGGDMYGRKKGLSIVVSVYIVGIIIQIASINK------WYQYFIGRIISGLGVGGIA 191

  Fly   164 SPVGVYSAEISLPKIRGRLILGTSLGLASGILLMYCLGYFIR---HNIQLIFGISCC-----YQL 220
            ....:..:||:...:||.|:....|.:.:||.|.||..|..:   :::|....:..|     :.:
Yeast   192 VLCPMLISEIAPKHLRGTLVSCYQLMITAGIFLGYCTNYGTKSYSNSVQWRVPLGLCFAWSLFMI 256

  Fly   221 AATLLVFPMPESPSWLLTRGKEERARKSLRYFRGLPKKEVDYVPEFEAELAHMK---ELADASNT 282
            .|..||   ||||.:|....|.|.|::|:.....:..::    |..:|||..:.   |....:..
Yeast   257 GALTLV---PESPRYLCEVNKVEDAKRSIAKSNKVSPED----PAVQAELDLIMAGIEAEKLAGN 314

  Fly   283 TAAGESLSQMIHRPEVYKPVLMMTTFFGFQQACGVVVIIVYAVQIAQQAGVTIDPVLVAVMLGVA 347
            .:.||..|.   :.:|::.:||......|||..|......|...|.:..|:. |....::::||.
Yeast   315 ASWGELFST---KTKVFQRLLMGVFVQMFQQLTGNNYFFYYGTVIFKSVGLD-DSFETSIVIGVV 375

  Fly   348 RIITTLFMSGIFEKWGRKPSGIFSATGMGACMLLLAG---------GNWFPDTLG---------- 393
            ...:|.|.....|..|.:...:..|..|.|||::.|.         |...|.:.|
Yeast   376 NFASTFFSLWTVENLGHRKCLLLGAATMMACMVIYASVGVTRLYPHGKSQPSSKGAGNCMIVFTC 440

  Fly   394 ------TLHWLPVACIVAHIVFSTMGMLTLPFFMISEVFPQRARGSASGIAIFFGMILAFIMLKI 452
                  ...|.|||.::.                 :|.||.|.:.....:|.....:..|::...
Yeast   441 FYIFCYATTWAPVAWVIT-----------------AESFPLRVKSKCMALASASNWVWGFLIAFF 488

  Fly   453 YPNMEAALGTANLFAFYAGISF---LAAAFIGV--FVPETRGRTLEELEERWQTGKF-------- 504
            .|.:.:|:.      ||.|..|   |.|.|..|  |||||:|.:|||::|.|:.|..
Yeast   489 TPFITSAIN------FYYGYVFMGCLVAMFFYVFFFVPETKGLSLEEIQELWEEGVLPWKSEGWI 547

  Fly   505 --SRRLTIVNLKDVE 517
              |||....:|:|::
Yeast   548 PSSRRGNNYDLEDLQ 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	105/469 (22%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	108/468 (23%)
GAL2	NP_013182.1	Sugar_tr	74..534	CDD:278511	117/500 (23%)
GAL2	NP_013182.1	MFS	75..518	CDD:119392	107/483 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342938
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740