DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4607 and SLC2A4

DIOPT Version :9

Sequence 1:	NP_572380.1	Gene:	CG4607 / 31653	FlyBaseID:	FBgn0029932	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens

Alignment Length:	486	Identity:	124/486 - (25%)
Similarity:	206/486 - (42%)	Gaps:	69/486 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LMVFLGNSGVLGSGM------VVSMPAVTLNQLHDETQPFWLNKD-------------ESSWFAS 92
            |.||   |.||||..      |::.|...:.|.::||   ||.:.             .:.|..|
Human    26 LAVF---SAVLGSLQFGYNIGVINAPQKVIEQSYNET---WLGRQGPEGPSSIPPGTLTTLWALS 84

  Fly    93 IQNMACPLGGLLVSYFLDRI----GRKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQMLLGRC 153
            :...:  :||::.|:.:..|    |||..:|:.|::.::|..|:..    ::....|..::|||.
Human    85 VAIFS--VGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGL----ANAAASYEMLILGRF 143

  Fly   154 FGGIMIGMFVSPVGVYSAEISLPKIRGRLILGTSLGLASGILLMYCLGYFIRHNIQLIFGISCCY 218
            ..|...|:....|.:|..||:...:||.|.....|.:..|||:...||      ::.:.|.:..:
Human   144 LIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLG------LESLLGTASLW 202

  Fly   219 QLAATLLVFP----------MPESPSWL-LTRGKEERARKSLRYFRGLPKKEVDYVPEFEAELAH 272
            .|...|.|.|          .||||.:| :.:..|..|||||:...|...     |....|||..
Human   203 PLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWAD-----VSGVLAELKD 262

  Fly   273 MKELADASNTTAAGESLSQMIHR-PEVYKPVLMMTTFFGFQQACGVVVIIVYAVQIAQQAGVTID 336
            .|...:.....:..:.|....|| |.:...||.::     ||..|:..:..|:..|.:.|||. .
Human   263 EKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLS-----QQLSGINAVFYYSTSIFETAGVG-Q 321

  Fly   337 PVLVAVMLGVARIITTLFMSGIFEKWGRKPSGIFSATGMGACMLLLAGGNWFPDTLGTLHWLPVA 401
            |....:..||...:.||....:.|:.||:...:....||..|.:|:.......:.:..:.::.:.
Human   322 PAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIV 386

  Fly   402 CIVAHIVFSTMGMLTLPFFMISEVFPQRARGSASGIAIFFGMILAFIMLKIYPNMEAALGTANLF 466
            .|...:.|..:|...:|:|:::|:|.|..|.:|..:|.|......||:...:..:..|:|.   :
Human   387 AIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGP---Y 448

  Fly   467 AFYAGISFLAAAFIGVF--VPETRGRTLEEL 495
            .|......|...||..|  ||||||||.:::
Human   449 VFLLFAVLLLGFFIFTFLRVPETRGRTFDQI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS	55..484	CDD:119392	112/465 (24%)
CG4607	NP_572380.1	SP	67..495	CDD:273317	114/458 (25%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269\|PubMed:16647043	7..13
		Sugar_tr	27..483	CDD:306568	123/485 (25%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		3/5 (60%)
		Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:8300557	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840