Protein Alignment CG4607 and SLC2A3

DIOPT Version :10

• Sequence 1: NP_572380.1
• Gene: CG4607 / 31653
• FlyBaseID: FBgn0029932
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 431
• Identity: 108/431 - (25%)
• Similarity: 194/431 - (45%)
• Gaps: 42/431 - (9%)

  Fly    87 SSWFASIQNMACPLGGLLVSY----FLDRIGRKHTILLTNLIGLIGWILLVTSFMHSDRDMIYYQ 147
            |.|..|:...:  :||::.|:    |::|.||::::|:.||:.:.|...:....:....:|
Human    61 SLWSLSVAIFS--VGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEM---- 119

  Fly   148 MLLGRCFGGIMIGMFVSPVGVYSAEISLPKIRGRLILGTSLGLASGILLMYCLGYFIRHNIQLIF 212
            ::|||...|:..|:....|.:|..|||...:||.......||:..|||:....|      ::.|.
Human   120 LILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFG------LEFIL 178

  Fly   213 GISCCYQLAATLLVFP----------MPESPSWLL-TRGKEERARKSLRYFRGLPKKEVDYVPEF 266
            |....:.|.....:.|          .||||.:|| .|.:||.|::.|:...|......| :.|.
Human   179 GSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQD-IQEM 242

  Fly   267 EAELAHMKELADASNTTAAGESLSQMIHRPEVYKPVLMMTTFFGFQQACGVVVIIVYAVQIAQQA 331
            :.|.|.|.:....        ::.::.......:|:::.......||..|:..:..|:..|.:.|
Human   243 KDESARMSQEKQV--------TVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDA 299

  Fly   332 GVTIDPVLVAVMLGVARIITTLFMSGIFEKWGRKPSGIFSATGMGACMLLLAGGNWFPDTLGTLH 396
            ||. :|:...:..||...|.|:....:.|:.||:...:....||..|..|:.......|....:.
Human   300 GVQ-EPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMS 363

  Fly   397 WLPVACIVAHIVFSTMGMLTLPFFMISEVFPQRARGSASGIAIFFGMILAFIMLKIYPNMEAALG 461
            ::.:..|:..:.|..:|...:|:|:::|:|.|..|.:|..:|........|::..::|:....||
Human   364 FVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLG 428

  Fly   462 TANLFAFYAG--ISFLAAAFIGVFVPETRGRTLEELEERWQ 500
             |.:|..:.|  |:|||..|..  ||||||||.|::...::
Human   429 -AYVFIIFTGFLITFLAFTFFK--VPETRGRTFEDITRAFE 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4607	NP_572380.1	MFS_GLUT6_8_Class3_like	47..494	CDD:340916	107/423 (25%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	104/419 (25%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)